Gmcl1 germ cell-less, spermatogenesis associated 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gmcl1provided by MGI
Official Full Name: germ cell-less, spermatogenesis associated 1provided by MGI
Primary source: MGI:MGI:1345156
See related: Ensembl:ENSMUSG00000001157 AllianceGenome:MGI:1345156
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DIP; Gcl; Gcl-1; glc-1; Btbd13; mglc-1; 2810049L19Rik
Summary: Acts upstream of or within regulation of transcription, DNA-templated. Located in nuclear envelope and nuclear matrix. Is expressed in several structures, including eye; genitourinary system; hemolymphoid system gland; liver; and lung. Orthologous to several human genes including GMCL1 (germ cell-less 1, spermatogenesis associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 18.2), CNS E14 (RPKM 8.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 37.75 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (86668750..86710377, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (86691768..86733395, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gmcl1 interacts with the DP component of the E2F transcription factor.
Title: Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor.
the mgcl-1 gene product appears to be essential for appropriate nuclear-lamina organization, which in turn is essential for normal sperm morphogenesis and chromatin remodeling.
Title: Mouse germ cell-less as an essential component for nuclear integrity.
mGCL-1 is a factor modulating MDM2-p53 axis by enhanced degradation of MDM2
Title: Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gcl (e-PCR), detects polymorphism
- UniSTS:164687

BB540852 (e-PCR)
- UniSTS:207990

RH128814 (e-PCR)
- UniSTS:212122

NoName (e-PCR)
- UniSTS:235484

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in germ cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within spermatogenesis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: germ cell-less protein-like 1

Names: DP-interacting protein; germ cell-less homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011818.3 → NP_035948.3 germ cell-less protein-like 1

See identical proteins and their annotated locations for NP_035948.3

Status: VALIDATED

Source sequence(s)

AF163665, AK004716, CJ122611, CX567687

Consensus CDS

CCDS20316.1

UniProtKB/Swiss-Prot

Q920G9, Q9DBW5, Q9QUP6

UniProtKB/TrEMBL

Q3UID6

Related

ENSMUSP00000001185.8, ENSMUST00000001185.14

Conserved Domains (3) summary

smart00225
Location:107 → 206

BTB; Broad-Complex, Tramtrack and Bric a brac

smart00875
Location:211 → 281

BACK; BTB And C-terminal Kelch

pfam00651
Location:96 → 203

BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

86668750..86710377 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506056.4 → XP_006506119.1 germ cell-less protein-like 1 isoform X1

Conserved Domains (1) summary

cl28903
Location:1 → 45

BACK; BACK (BTB and C-terminal Kelch) domain