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G3bp2 G3BP stress granule assembly factor 2 [ Mus musculus (house mouse) ]

Gene ID: 23881, updated on 5-Mar-2024

Summary

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Official Symbol
G3bp2provided by MGI
Official Full Name
G3BP stress granule assembly factor 2provided by MGI
Primary source
MGI:MGI:2442040
See related
Ensembl:ENSMUSG00000029405 AllianceGenome:MGI:2442040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G3BP; mKIAA0660; E430034L04Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of stress granule assembly and protein homooligomerization. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be located in cytoplasmic stress granule. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol. Is expressed in several structures, including central nervous system; ovary; sensory organ; and tooth. Orthologous to human G3BP2 (G3BP stress granule assembly factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 38.0), whole brain E14.5 (RPKM 34.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See G3bp2 in Genome Data Viewer
Location:
5 E2; 5 45.84 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92200004..92285584, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (92052145..92137725, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13624 Neighboring gene odontogenesis associated phosphoprotein Neighboring gene cyclin dependent kinase like 2 Neighboring gene predicted gene, 46915 Neighboring gene STARR-positive B cell enhancer mm9_chr5:92471665-92471966 Neighboring gene predicted gene, 22728 Neighboring gene predicted gene, 42111 Neighboring gene STARR-positive B cell enhancer mm9_chr5:92512687-92512988 Neighboring gene predicted gene, 46933 Neighboring gene STARR-seq mESC enhancer starr_13632 Neighboring gene uncharacterized LOC105246914 Neighboring gene STARR-seq mESC enhancer starr_13633 Neighboring gene STARR-positive B cell enhancer ABC_E11293 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene USO1 vesicle docking factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:92612573-92612756 Neighboring gene predicted gene, 25290

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. G3BP2, a stress granule assembly factor, is dispensable for spermatogenesis in mice. Yun D, et al. PeerJ, 2022. PMID 35782098, Free PMC Article
  2. Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif. Kennedy D, et al. Biomed Pept Proteins Nucleic Acids, 1996-1997. PMID 9575347
  3. Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2. Bikkavilli RK, et al. J Cell Sci, 2012 May 15. PMID 22357953, Free PMC Article
  4. Single-cell transcriptome landscape of ovarian cells during primordial follicle assembly in mice. Wang JJ, et al. PLoS Biol, 2020 Dec. PMID 33351795, Free PMC Article
  5. G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. Kedersha N, et al. J Cell Biol, 2016 Mar 28. PMID 27022092, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. G3BP2, a stress granule assembly factor, is dispensable for spermatogenesis in mice.
    Title: G3BP2, a stress granule assembly factor, is dispensable for spermatogenesis in mice.
  2. Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.
    Title: Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (7)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0660

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras GTPase-activating protein-binding protein 2
Names
GTPase activating protein (SH3 domain) binding protein 2
Ras-GTPase-activating protein (GAP120) SH3-domain binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080794.2 → NP_001074263.1  ras GTPase-activating protein-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_001074263.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
    Source sequence(s)
    AK153221, AK169571, BY578810, CN527272
    Consensus CDS
    CCDS19427.1
    UniProtKB/Swiss-Prot
    P97379, Q3UL55, Q9R1B8
    UniProtKB/TrEMBL
    Q3U541, Q3U931
    Related
    ENSMUSP00000128244.2, ENSMUST00000169094.8
    Conserved Domains (2) summary
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326 → 408
    RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

  2. NM_001080795.2 → NP_001074264.1  ras GTPase-activating protein-binding protein 2 isoform b

    See identical proteins and their annotated locations for NP_001074264.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 4, and 8 all encode the same isoform (b).
    Source sequence(s)
    AK076117, AK169571, BY272229, BY578810
    Consensus CDS
    CCDS39149.1
    UniProtKB/TrEMBL
    Q3U931, Q542W3
    Related
    ENSMUSP00000108752.4, ENSMUST00000113127.7
    Conserved Domains (2) summary
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:293 → 375
    RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

  3. NM_001080796.2 → NP_001074265.1  ras GTPase-activating protein-binding protein 2 isoform b

    See identical proteins and their annotated locations for NP_001074265.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 4, and 8 all encode the same isoform (b).
    Source sequence(s)
    AK151732, AK169571, BY578810, CN527272
    Consensus CDS
    CCDS39149.1
    UniProtKB/TrEMBL
    Q3U931, Q542W3
    Related
    ENSMUSP00000132469.2, ENSMUST00000167918.8
    Conserved Domains (2) summary
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:293 → 375
    RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

  4. NM_001080797.2 → NP_001074266.1  ras GTPase-activating protein-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_001074266.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
    Source sequence(s)
    AK149427, AK169571, BY578810
    Consensus CDS
    CCDS19427.1
    UniProtKB/Swiss-Prot
    P97379, Q3UL55, Q9R1B8
    UniProtKB/TrEMBL
    Q3U541, Q3U931
    Related
    ENSMUSP00000128353.2, ENSMUST00000164378.8
    Conserved Domains (2) summary
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326 → 408
    RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

  5. NM_001359195.1 → NP_001346124.1  ras GTPase-activating protein-binding protein 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
    Source sequence(s)
    AC122438, AC165433
    Consensus CDS
    CCDS19427.1
    UniProtKB/Swiss-Prot
    P97379, Q3UL55, Q9R1B8
    UniProtKB/TrEMBL
    Q3U541, Q3U931
    Conserved Domains (2) summary
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326 → 408
    RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

  6. NM_001359196.1 → NP_001346125.1  ras GTPase-activating protein-binding protein 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
    Source sequence(s)
    AC122438, AC165433
    Consensus CDS
    CCDS19427.1
    UniProtKB/Swiss-Prot
    P97379, Q3UL55, Q9R1B8
    UniProtKB/TrEMBL
    Q3U541, Q3U931
    Conserved Domains (2) summary
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326 → 408
    RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

  7. NM_001359197.1 → NP_001346126.1  ras GTPase-activating protein-binding protein 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 4, and 8 all encode the same isoform (b).
    Source sequence(s)
    AC122438, AC165433
    Consensus CDS
    CCDS39149.1
    UniProtKB/TrEMBL
    Q3U931, Q542W3
    Conserved Domains (2) summary
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:293 → 375
    RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

  8. NM_011816.4 → NP_035946.2  ras GTPase-activating protein-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_035946.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 5, 6, and 7 all encode the same isoform (a).
    Source sequence(s)
    AK145697, AK169571, BY272229, BY578810
    Consensus CDS
    CCDS19427.1
    UniProtKB/Swiss-Prot
    P97379, Q3UL55, Q9R1B8
    UniProtKB/TrEMBL
    Q3U541, Q3U931
    Related
    ENSMUSP00000144456.2, ENSMUST00000202258.4
    Conserved Domains (2) summary
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:326 → 408
    RRM_G3BP2; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    92200004..92285584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254467.1 → XP_030110327.1  ras GTPase-activating protein-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    Q3U931, Q542W3
    Conserved Domains (2) summary
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12464
    Location:293 → 375
    RRM_G3BP2; RNA recognition motif in ras GTPase-activating protein-binding protein 2 (G3BP2) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97379.2 GenPept UniProtKB/Swiss-Prot:P97379

Gene LinkOut

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