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Tnpo1 transportin 1 [ Mus musculus (house mouse) ]

Gene ID: 238799, updated on 11-Apr-2024

Summary

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Official Symbol
Tnpo1provided by MGI
Official Full Name
transportin 1provided by MGI
Primary source
MGI:MGI:2681523
See related
Ensembl:ENSMUSG00000009470 AllianceGenome:MGI:2681523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MIP; TRN; IPO2; MIP1; Kpnb2; D13Ertd688e
Summary
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within protein transport. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNPO1 (transportin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 23.2), whole brain E14.5 (RPKM 19.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 D1; 13 52.24 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (98975527..99062851, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (98839019..98926384, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene FCH domain only 2 Neighboring gene predicted gene, 34995 Neighboring gene ribosomal protein S17 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:99660904-99661128 Neighboring gene ribosomal protein L27A, pseudogene 4 Neighboring gene predicted gene, 52051 Neighboring gene predicted gene, 35215 Neighboring gene predicted gene, 47052

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transportin 1 in the mouse brain: appearance in regions of neurogenesis, cerebrospinal fluid production/sensing, and circadian clock. Sato M, et al. J Comp Neurol, 2011 Jun 15. PMID 21452213
  2. Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor. Di Benedetto A, et al. Proc Natl Acad Sci U S A, 2014 Nov 18. PMID 25378700, Free PMC Article
  3. Reactive oxygen species-mediated DJ-1 monomerization modulates intracellular trafficking involving karyopherin β2. Björkblom B, et al. Mol Cell Biol, 2014 Aug. PMID 24912681, Free PMC Article
  4. A role for Rab23 in the trafficking of Kif17 to the primary cilium. Lim YS, et al. J Cell Sci, 2015 Aug 15. PMID 26136363
  5. Involvement of transportin 2-mediated HuR import in muscle cell differentiation. van der Giessen K, et al. Mol Biol Cell, 2007 Jul. PMID 17475777, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Co-immunoprecipitation and affinity-binding studies revealed that Rab23 exists in a complex with Kif17 and importin b2 implying that Kif17 needs to bind to regulatory proteins like Rab23 for its ciliary transport
    Title: A role for Rab23 in the trafficking of Kif17 to the primary cilium.
  2. Association with Tnpo1 is necessary for Oxtr nuclear localization. This is required for Oxt-induced osteoblast differentiation. osteoblast differentiation.
    Title: Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor.
  3. DJ-1 import is mediated by an oxidative stress-dependent interaction with karyopherin beta2.
    Title: Reactive oxygen species-mediated DJ-1 monomerization modulates intracellular trafficking involving karyopherin β2.
  4. Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin protein.
    Title: Identification of a karyopherin β1/β2 proline-tyrosine nuclear localization signal in huntingtin protein.
  5. Tnpo1 is involved in a variety of functions in the adult brain, including neurogenesis, cerebrospinal fluid production and sensing, and circadian rhythms.
    Title: Transportin 1 in the mouse brain: appearance in regions of neurogenesis, cerebrospinal fluid production/sensing, and circadian clock.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transportin-1
Names
importin beta-2
karyopherin (importin) beta 2
karyopherin beta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048267.2 → NP_001041732.1  transportin-1 isoform 2

    See identical proteins and their annotated locations for NP_001041732.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC129085, AC154849
    Consensus CDS
    CCDS36760.1
    UniProtKB/TrEMBL
    Q3TKD0
    Related
    ENSMUSP00000105026.3, ENSMUST00000109399.9
    Conserved Domains (2) summary
    COG5215
    Location:24 → 759
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:95 → 116
    HEAT; HEAT repeat [structural motif]

  2. NM_001426412.1 → NP_001413341.1  transportin-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC129085, AC154849

  3. NM_001426413.1 → NP_001413342.1  transportin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129085, AC154849

  4. NM_001426414.1 → NP_001413343.1  transportin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129085, AC154849

  5. NM_001426415.1 → NP_001413344.1  transportin-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC129085, AC154849

  6. NM_178716.4 → NP_848831.2  transportin-1 isoform 1

    See identical proteins and their annotated locations for NP_848831.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC129085, AC154849
    Consensus CDS
    CCDS26717.2
    UniProtKB/Swiss-Prot
    Q8BFY9, Q8C0S3, Q8K2E7
    UniProtKB/TrEMBL
    Q3TKD0
    Related
    ENSMUSP00000105028.2, ENSMUST00000109401.8
    Conserved Domains (2) summary
    COG5215
    Location:32 → 767
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:103 → 124
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_189735.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129085, AC154849

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    98975527..99062851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFY9.2 GenPept UniProtKB/Swiss-Prot:Q8BFY9

Gene LinkOut

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