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Farsb phenylalanyl-tRNA synthetase, beta subunit [ Mus musculus (house mouse) ]

Gene ID: 23874, updated on 3-Apr-2024

Summary

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Official Symbol
Farsbprovided by MGI
Official Full Name
phenylalanyl-tRNA synthetase, beta subunitprovided by MGI
Primary source
MGI:MGI:1346035
See related
Ensembl:ENSMUSG00000026245 AllianceGenome:MGI:1346035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Frsb; Farsa; Farsl; Farslb
Summary
Predicted to enable phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and protein heterotetramerization. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of phenylalanine-tRNA ligase complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human FARSB (phenylalanyl-tRNA synthetase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 23.6), liver E14 (RPKM 19.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C4; 1 40.44 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (78394593..78465530, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (78417958..78488897, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate phosphatase 2 Neighboring gene predicted gene, 51634 Neighboring gene STARR-seq mESC enhancer starr_01426 Neighboring gene STARR-positive B cell enhancer ABC_E4327 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9179 Neighboring gene STARR-seq mESC enhancer starr_01427 Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E5774 Neighboring gene STARR-positive B cell enhancer ABC_E322 Neighboring gene predicted gene, 39665 Neighboring gene RIKEN cDNA 5730419F03 gene Neighboring gene STARR-seq mESC enhancer starr_01430 Neighboring gene STARR-seq mESC enhancer starr_01431 Neighboring gene predicted gene, 57683

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning of the cDNA encoding phenylalanyl tRNA synthetase regulatory alpha-subunit-like protein whose expression is down-regulated during differentiation. Zhou X, et al. Gene, 1999 Jun 11. PMID 10375616
  2. Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes. Boettger-Tong HL, et al. Biochem Biophys Res Commun, 2001 Nov 16. PMID 11700028
  3. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684
  4. Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. Zhou X, et al. J Cell Biol, 2015 Sep 14. PMID 26370502, Free PMC Article
  5. ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. Cozzolino F, et al. Hum Mol Genet, 2021 Jun 17. PMID 33601422

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to phenylalanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phenylalanine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in phenylalanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylalanyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein heterotetramerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of phenylalanine-tRNA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phenylalanine-tRNA ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phenylalanine--tRNA ligase beta subunit
Names
PheRS alpha
phenylalanine tRNA synthetase alpha
phenylalanine--tRNA ligase beta chain
phenylalanine-tRNA synthetase-like, beta subunit
phenylalanyl-tRNA synthetase beta chain
NP_001265004.1
NP_001408307.1
NP_001408308.1
NP_001408309.1
NP_001408310.1
NP_001408311.1
NP_001408312.1
NP_035941.2
XP_036020538.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278075.2 → NP_001265004.1  phenylalanine--tRNA ligase beta subunit isoform 1

    See identical proteins and their annotated locations for NP_001265004.1

    Status: VALIDATED

    Source sequence(s)
    AC115932, AC158559
    Consensus CDS
    CCDS15084.1
    UniProtKB/Swiss-Prot
    Q9CWZ8, Q9WUA2
    UniProtKB/TrEMBL
    Q3TG12, Q8C644
    Related
    ENSMUSP00000129828.2, ENSMUST00000170217.8
    Conserved Domains (4) summary
    smart00873
    Location:118 → 279
    B3_4; B3/4 domain
    PLN02265
    Location:1 → 589
    PLN02265; probable phenylalanyl-tRNA synthetase beta chain
    cd00769
    Location:392 → 588
    PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
    pfam03484
    Location:310 → 374
    B5; tRNA synthetase B5 domain

  2. NM_001421378.1 → NP_001408307.1  phenylalanine--tRNA ligase beta subunit isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115932, AC158559

  3. NM_001421379.1 → NP_001408308.1  phenylalanine--tRNA ligase beta subunit isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115932, AC158559

  4. NM_001421380.1 → NP_001408309.1  phenylalanine--tRNA ligase beta subunit isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC115932, AC158559

  5. NM_001421381.1 → NP_001408310.1  phenylalanine--tRNA ligase beta subunit isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC115932, AC158559

  6. NM_001421382.1 → NP_001408311.1  phenylalanine--tRNA ligase beta subunit isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC115932, AC158559

  7. NM_001421383.1 → NP_001408312.1  phenylalanine--tRNA ligase beta subunit isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC115932, AC158559

  8. NM_011811.5 → NP_035941.2  phenylalanine--tRNA ligase beta subunit isoform 1

    See identical proteins and their annotated locations for NP_035941.2

    Status: VALIDATED

    Source sequence(s)
    AC115932, AC158559
    Consensus CDS
    CCDS15084.1
    UniProtKB/Swiss-Prot
    Q9CWZ8, Q9WUA2
    UniProtKB/TrEMBL
    Q3TG12, Q8C644
    Related
    ENSMUSP00000069508.8, ENSMUST00000068333.14
    Conserved Domains (4) summary
    smart00873
    Location:118 → 279
    B3_4; B3/4 domain
    PLN02265
    Location:1 → 589
    PLN02265; probable phenylalanyl-tRNA synthetase beta chain
    cd00769
    Location:392 → 588
    PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
    pfam03484
    Location:310 → 374
    B5; tRNA synthetase B5 domain

RNA

  1. NR_102757.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC115932, AC158559
    Related
    ENSMUST00000189529.7

  2. NR_102758.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC115932, AC158559

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    78394593..78465530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164645.1 → XP_036020538.1  phenylalanine--tRNA ligase beta subunit isoform X1

    UniProtKB/TrEMBL
    Q3TG12
    Conserved Domains (1) summary
    PLN02265
    Location:27 → 595
    PLN02265; probable phenylalanyl-tRNA synthetase beta chain

RNA

  1. XR_865550.2 RNA Sequence

  2. XR_004942238.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUA2.2 GenPept UniProtKB/Swiss-Prot:Q9WUA2

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