U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Faim Fas apoptotic inhibitory molecule [ Mus musculus (house mouse) ]

Gene ID: 23873, updated on 8-Feb-2024

Summary

Go to the top of the page Help
Official Symbol
Faimprovided by MGI
Official Full Name
Fas apoptotic inhibitory moleculeprovided by MGI
Primary source
MGI:MGI:1344387
See related
Ensembl:ENSMUSG00000032463 AllianceGenome:MGI:1344387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in cytoplasm. Is expressed in several structures, including gonad; hemolymphoid system; intestine; liver; and retina. Orthologous to human FAIM (Fas apoptotic inhibitory molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 11.2), CNS E14 (RPKM 8.8) and 24 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 E3.3; 9 51.41 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (98868426..98884076)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (98986373..99002019)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene forkhead box L2, opposite strand Neighboring gene forkhead box L2 Neighboring gene STARR-positive B cell enhancer mm9_chr9:98886571-98886872 Neighboring gene predicted gene 1123 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Neighboring gene STARR-seq mESC enhancer starr_25010 Neighboring gene predicted gene 2773

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Faim knockout leads to gliosis and late-onset neurodegeneration of photoreceptors in the mouse retina. Sirés A, et al. J Neurosci Res, 2021 Dec. PMID 34713467
  2. Fas apoptosis inhibitory molecule contains a novel beta-sandwich in contact with a partially ordered domain. Hemond M, et al. J Mol Biol, 2009 Mar 6. PMID 19168072, Free PMC Article
  3. An alternatively spliced long form of Fas apoptosis inhibitory molecule (FAIM) with tissue-specific expression in the brain. Zhong X, et al. Mol Immunol, 2001 Jan. PMID 11483211
  4. Receptor-specific regulation of B-cell susceptibility to Fas-mediated apoptosis and a novel Fas apoptosis inhibitory molecule. Rothstein TL, et al. Immunol Rev, 2000 Aug. PMID 11043772
  5. The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers Arrestin-1 Translocation upon Light Reception in the Retina. Sirés A, et al. Cells, 2023 Feb 2. PMID 36766830, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers Arrestin-1 Translocation upon Light Reception in the Retina.
    Title: The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers Arrestin-1 Translocation upon Light Reception in the Retina.
  2. PACAP attenuates hepatic lipid accumulation through the FAIM/AMPK/IRbeta axis during overnutrition.
    Title: PACAP attenuates hepatic lipid accumulation through the FAIM/AMPK/IRβ axis during overnutrition.
  3. Faim knockout leads to gliosis and late-onset neurodegeneration of photoreceptors in the mouse retina.
    Title: Faim knockout leads to gliosis and late-onset neurodegeneration of photoreceptors in the mouse retina.
  4. SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
    Title: SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
  5. The neuron-specific form of FAIM protein (FAIM-L) is a death receptor antagonist that stabilizes XIAP protein levels, thus preventing death receptor-induced neuronal apoptosis. Here we show that FAIM-L modulates synaptic transmission, prevents chemical-LTD induction in hippocampal neurons, and thwarts axon degeneration after nerve growth factor (NGF) withdrawal.
    Title: FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration.
  6. Data indicate that FAIM is a novel regulator of insulin signalling and plays an essential role in energy homoeostasis.
    Title: Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis.
  7. defined a TCR-induced FAIM/Akt/Nur77 signaling axis that is critical for modulating the apoptosis of developing thymocytes
    Title: Fas apoptosis inhibitory molecule regulates T cell receptor-mediated apoptosis of thymocytes by modulating Akt activation and Nur77 expression.
  8. FAIM is expressed in germinal center B cells, enhances interferon regulatory factor (IRF)4 expression, and is in turn positively regulated through IRF4 in a positive reinforcing (i.e., feed-forward) system.
    Title: Fas apoptosis inhibitory molecule expression in B cells is regulated through IRF4 in a feed-forward mechanism.
  9. FAIM plays a novel role in modulating Fas-mediated apoptosis and acts through influencing the expression of c-FLIP and regulating the physical binding of caspase-8 to Fas.
    Title: Genetic deletion of faim reveals its role in modulating c-FLIP expression during CD95-mediated apoptosis of lymphocytes and hepatocytes.
  10. The NMR solution structure of the C-terminal domain of murine FAIM is solved in isolation and revealed to be a novel protein fold, a noninterleaved seven-stranded beta-sandwich.
    Title: Fas apoptosis inhibitory molecule contains a novel beta-sandwich in contact with a partially ordered domain.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
fas apoptotic inhibitory molecule 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122851.1 → NP_001116323.1  fas apoptotic inhibitory molecule 1 isoform Faim-L

    See identical proteins and their annotated locations for NP_001116323.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (Faim-L).
    Source sequence(s)
    BC079662, BU962258
    Consensus CDS
    CCDS52897.1
    UniProtKB/TrEMBL
    A0A087WRH2, D3Z3C1
    Related
    ENSMUSP00000108532.3, ENSMUST00000112911.9
    Conserved Domains (1) summary
    pfam06905
    Location:24 → 198
    FAIM1; Fas apoptotic inhibitory molecule (FAIM1)

  2. NM_011810.3 → NP_035940.3  fas apoptotic inhibitory molecule 1 isoform Faim-S

    See identical proteins and their annotated locations for NP_035940.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks the exon containing the translation start codon compared to variant 1. The resulting isoform (Faim-S) has a shorter N-terminus compared to isoform Faim-L.
    Source sequence(s)
    BC079662, BU962258, BY055691
    Consensus CDS
    CCDS23431.1
    UniProtKB/Swiss-Prot
    Q9DAK6, Q9WUD8
    UniProtKB/TrEMBL
    A0A087WRH2
    Related
    ENSMUSP00000035038.2, ENSMUST00000035038.8
    Conserved Domains (1) summary
    pfam06905
    Location:3 → 174
    FAIM1; Fas apoptotic inhibitory molecule (FAIM1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    98868426..98884076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154930.1 → XP_036010823.1  fas apoptotic inhibitory molecule 1 isoform X1

    UniProtKB/TrEMBL
    A0A087WRH2, D3Z3C1
    Conserved Domains (1) summary
    pfam06905
    Location:24 → 198
    FAIM1; Fas apoptotic inhibitory molecule (FAIM1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUD8.1 GenPept UniProtKB/Swiss-Prot:Q9WUD8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous