Zfp874a zinc finger protein 874a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp874aprovided by MGI
Official Full Name: zinc finger protein 874aprovided by MGI
Primary source: MGI:MGI:3040703
See related: Ensembl:ENSMUSG00000069206 AllianceGenome:MGI:3040703
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zfp874; Rslcan15; C330011K17Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF429 (zinc finger protein 429). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 2.4), cortex adult (RPKM 2.1) and 24 other tissues See more
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Genomic context

Location:: 13 B3; 13 34.54 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (67588550..67599743, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (67440431..67451624, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

Psme2 (e-PCR), detects polymorphism
- UniSTS:256483

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 874

Names: KRAB zinc finger protein; regulator of sex-limitation candidate 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177712.4 → NP_808380.1 zinc finger protein 874

See identical proteins and their annotated locations for NP_808380.1

Status: VALIDATED

Source sequence(s)

AK145787, BC080824

Consensus CDS

CCDS56891.1

UniProtKB/TrEMBL

Q8BX23

Related

ENSMUSP00000074735.6, ENSMUST00000075255.6

Conserved Domains (5) summary

smart00349
Location:5 → 59

KRAB; krueppel associated box

COG5048
Location:59 → 351

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:167 → 187

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:5 → 44

KRAB; KRAB box

pfam13465
Location:179 → 204

zf-H2C2_2; Zinc-finger double domain