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Zfp458 zinc finger protein 458 [ Mus musculus (house mouse) ]

Gene ID: 238690, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp458provided by MGI
Official Full Name
zinc finger protein 458provided by MGI
Primary source
MGI:MGI:3040691
See related
Ensembl:ENSMUSG00000055480 AllianceGenome:MGI:3040691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf728; Gm33446; Rslcan-7; mszf59-2
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated; negative regulation of transposon integration; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF107 (zinc finger protein 107); ZNF43 (zinc finger protein 43); and ZNF493 (zinc finger protein 493). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Zfp458 in Genome Data Viewer
Location:
13 B3; 13 34.54 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67350853..67417844, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67225137..67278498, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2411 Neighboring gene regulator of sex limited protein 1 Neighboring gene protein FAM220A-like Neighboring gene zinc finger protein 455 Neighboring gene STARR-seq mESC enhancer starr_34895 Neighboring gene STARR-seq mESC enhancer starr_34896 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:67370040-67370149 Neighboring gene RIKEN cDNA F630042J09 gene Neighboring gene STARR-seq mESC enhancer starr_34898 Neighboring gene zinc finger protein 457

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs CJ, et al. Genes Dev, 2003 Nov 1. PMID 14563677, Free PMC Article
  2. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 728

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001152.2 → NP_001001152.1  zinc finger protein 728

    See identical proteins and their annotated locations for NP_001001152.1

    Status: VALIDATED

    Source sequence(s)
    AC159264, AC163667
    Consensus CDS
    CCDS36710.1
    UniProtKB/Swiss-Prot
    Q6P5C7
    Related
    ENSMUSP00000047222.8, ENSMUST00000045969.8
    Conserved Domains (5) summary
    smart00349
    Location:5 → 63
    KRAB; krueppel associated box
    COG5048
    Location:107 → 520
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5 → 44
    KRAB; KRAB box
    pfam13465
    Location:348 → 372
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_155551.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159264, AC163667

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    67350853..67417844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158041.1 → XP_036013934.1  zinc finger protein 728 isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:43 → 101
    KRAB; krueppel associated box
    COG5048
    Location:257 → 727
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:261 → 281
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:721 → 746
    zf-H2C2_2; Zinc-finger double domain
    NF033550
    Location:110 → 157
    transpos_ISL3; ISL3 family transposase

  2. XM_030247256.2 → XP_030103116.1  zinc finger protein 728 isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:43 → 101
    KRAB; krueppel associated box
    COG5048
    Location:257 → 727
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:261 → 281
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:721 → 746
    zf-H2C2_2; Zinc-finger double domain
    NF033550
    Location:110 → 157
    transpos_ISL3; ISL3 family transposase

  3. XM_017315510.3 → XP_017170999.1  zinc finger protein 728 isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:43 → 101
    KRAB; krueppel associated box
    COG5048
    Location:257 → 727
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:261 → 281
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:721 → 746
    zf-H2C2_2; Zinc-finger double domain
    NF033550
    Location:110 → 157
    transpos_ISL3; ISL3 family transposase

  4. XM_036158040.1 → XP_036013933.1  zinc finger protein 728 isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:43 → 101
    KRAB; krueppel associated box
    COG5048
    Location:257 → 727
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:261 → 281
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:721 → 746
    zf-H2C2_2; Zinc-finger double domain
    NF033550
    Location:110 → 157
    transpos_ISL3; ISL3 family transposase

  5. XM_030247259.1 → XP_030103119.1  zinc finger protein 728 isoform X2

    UniProtKB/TrEMBL
    Q7M6X6
    Related
    ENSMUSP00000153284.2, ENSMUST00000225772.2
    Conserved Domains (4) summary
    smart00349
    Location:2 → 60
    KRAB; krueppel associated box
    COG5048
    Location:104 → 517
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220 → 240
    ZF_C2H2; C2H2 Zn finger [structural motif]
    NF033550
    Location:69 → 116
    transpos_ISL3; ISL3 family transposase

  6. XM_036158043.1 → XP_036013936.1  zinc finger protein 728 isoform X2

    UniProtKB/TrEMBL
    Q7M6X6
    Conserved Domains (4) summary
    smart00349
    Location:2 → 60
    KRAB; krueppel associated box
    COG5048
    Location:104 → 517
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220 → 240
    ZF_C2H2; C2H2 Zn finger [structural motif]
    NF033550
    Location:69 → 116
    transpos_ISL3; ISL3 family transposase

  7. XM_036158042.1 → XP_036013935.1  zinc finger protein 728 isoform X2

    UniProtKB/TrEMBL
    Q7M6X6
    Conserved Domains (4) summary
    smart00349
    Location:2 → 60
    KRAB; krueppel associated box
    COG5048
    Location:104 → 517
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220 → 240
    ZF_C2H2; C2H2 Zn finger [structural motif]
    NF033550
    Location:69 → 116
    transpos_ISL3; ISL3 family transposase

  8. XM_030247257.2 → XP_030103117.1  zinc finger protein 728 isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:43 → 101
    KRAB; krueppel associated box
    COG5048
    Location:257 → 727
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:261 → 281
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:721 → 746
    zf-H2C2_2; Zinc-finger double domain
    NF033550
    Location:110 → 157
    transpos_ISL3; ISL3 family transposase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P5C7.1 GenPept UniProtKB/Swiss-Prot:Q6P5C7

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