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Dido1 death inducer-obliterator 1 [ Mus musculus (house mouse) ]

Gene ID: 23856, updated on 11-Apr-2024

Summary

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Official Symbol
Dido1provided by MGI
Official Full Name
death inducer-obliterator 1provided by MGI
Primary source
MGI:MGI:1344352
See related
Ensembl:ENSMUSG00000038914 AllianceGenome:MGI:1344352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dido; DIO-1; Datf1; DATF-1; 6720461J16Rik; C130092D22Rik; D130048F08Rik
Summary
This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.5), thymus adult (RPKM 4.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2; 2 H4
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180299757..180351886, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180657963..180710068, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene opioid growth factor receptor Neighboring gene collagen, type IX, alpha 3 Neighboring gene transcription factor-like 5 (basic helix-loop-helix) Neighboring gene predicted gene, 54097 Neighboring gene STARR-positive B cell enhancer mm9_chr2:180436639-180436940 Neighboring gene STARR-seq mESC enhancer starr_06736 Neighboring gene predicted gene, 22502 Neighboring gene STARR-positive B cell enhancer ABC_E9213 Neighboring gene GID complex subunit 8 Neighboring gene predicted gene, 30455 Neighboring gene solute carrier family 17, member 9 Neighboring gene STARR-seq mESC enhancer starr_06739 Neighboring gene STARR-positive B cell enhancer ABC_E1614 Neighboring gene basic helix-loop-helix family, member e23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levels. Fütterer A, et al. Cell Death Dis, 2021 Jun 21. PMID 34155199, Free PMC Article
  2. Dido mutations trigger perinatal death and generate brain abnormalities and behavioral alterations in surviving adult mice. Villares R, et al. Proc Natl Acad Sci U S A, 2015 Apr 14. PMID 25825751, Free PMC Article
  3. The death-inducer obliterator 1 (Dido1) gene regulates embryonic stem cell self-renewal. Liu Y, et al. J Biol Chem, 2014 Feb 21. PMID 24347171, Free PMC Article
  4. Dido3 PHD modulates cell differentiation and division. Gatchalian J, et al. Cell Rep, 2013 Jul 11. PMID 23831028, Free PMC Article
  5. Chronic stress and impaired glutamate function elicit a depressive-like phenotype and common changes in gene expression in the mouse frontal cortex. Tordera RM, et al. Eur Neuropsychopharmacol, 2011 Jan. PMID 20937555

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PARP1, DIDO3, and DHX9 Proteins Mutually Interact in Mouse Fibroblasts, with Effects on DNA Replication Dynamics, Senescence, and Oncogenic Transformation.
    Title: PARP1, DIDO3, and DHX9 Proteins Mutually Interact in Mouse Fibroblasts, with Effects on DNA Replication Dynamics, Senescence, and Oncogenic Transformation.
  2. DIDO is necessary for the adipogenesis that promotes diet-induced obesity.
    Title: DIDO is necessary for the adipogenesis that promotes diet-induced obesity.
  3. Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levels.
    Title: Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levels.
  4. Embryonic stem cells mainly express DIDO3 and their differentiation after leukemia inhibitory factor withdrawal requires DIDO1 expression. DIDO3 regulates DIDO1 expression.
    Title: DIDO as a Switchboard that Regulates Self-Renewal and Differentiation in Embryonic Stem Cells.
  5. Death inducer obliterator (Dido3)-dependent targeting of histone deacetylase 6 (HDAC6) is a key determinant of cilium size in growth-arrested cells
    Title: Dido3-dependent HDAC6 targeting controls cilium size.
  6. Data indicate that death inducer-obliterator (dido) mutant mice with high incidence of perinatal lethality and distinct neurodevelopmental, morphogenetic, and metabolic alterations.
    Title: Dido mutations trigger perinatal death and generate brain abnormalities and behavioral alterations in surviving adult mice.
  7. Dido1 is able to regulate self-renewal of mouse embryonic stem cells.
    Title: The death-inducer obliterator 1 (Dido1) gene regulates embryonic stem cell self-renewal.
  8. Dido3 PHD interacts with histone H3K4me3 and regulates expression of stemness genes in embryonic stem cells.
    Title: Dido3 PHD modulates cell differentiation and division.
  9. loss of Dido3 expression compromises differentiation of embryonic stem cells in vitro and of epiblast cells in vivo, resulting in early embryonic death at around day 8.5 of gestation
    Title: Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development.
  10. results indicate that histone H3 lysine 4 demethylation modulates DIDO3 localization in meiosis and suggest epigenetic regulation of the synaptonemal complex
    Title: Synaptonemal complex assembly and H3K4Me3 demethylation determine DIDO3 localization in meiosis.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • mKIAA0333, C530043I07

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
death-inducer obliterator 1
Names
death inducer-obliterator-2
death inducer-obliterator-3
death-associated transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291432.2 → NP_001278361.1  death-inducer obliterator 1 isoform Dido1

    See identical proteins and their annotated locations for NP_001278361.1

    Status: REVIEWED

    Source sequence(s)
    AL732560
    Consensus CDS
    CCDS17184.1
    UniProtKB/Swiss-Prot
    Q8C9B9
    Related
    ENSMUSP00000099344.2, ENSMUST00000103055.8
    Conserved Domains (3) summary
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam01749
    Location:165 → 241
    IBB; Importin beta binding domain
    pfam02724
    Location:122 → 192
    CDC45; CDC45-like protein

  2. NM_001291433.2 → NP_001278362.1  death-inducer obliterator 1 isoform Dido2

    See identical proteins and their annotated locations for NP_001278362.1

    Status: REVIEWED

    Source sequence(s)
    AL732560
    Consensus CDS
    CCDS17183.1
    UniProtKB/Swiss-Prot
    Q8C9B9
    Related
    ENSMUSP00000099345.4, ENSMUST00000103056.10
    Conserved Domains (4) summary
    smart00510
    Location:669 → 770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam01749
    Location:165 → 241
    IBB; Importin beta binding domain
    pfam07744
    Location:1052 → 1158
    SPOC; SPOC domain

  3. NM_011805.4 → NP_035935.2  death-inducer obliterator 1 isoform Dido1

    See identical proteins and their annotated locations for NP_035935.2

    Status: REVIEWED

    Source sequence(s)
    AL732560
    Consensus CDS
    CCDS17184.1
    UniProtKB/Swiss-Prot
    Q8C9B9
    Related
    ENSMUSP00000119689.2, ENSMUST00000130986.8
    Conserved Domains (3) summary
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam01749
    Location:165 → 241
    IBB; Importin beta binding domain
    pfam02724
    Location:122 → 192
    CDC45; CDC45-like protein

  4. NM_175551.5 → NP_780760.2  death-inducer obliterator 1 isoform Dido3

    See identical proteins and their annotated locations for NP_780760.2

    Status: REVIEWED

    Source sequence(s)
    AL732560
    Consensus CDS
    CCDS17182.1
    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Related
    ENSMUSP00000084794.4, ENSMUST00000087517.10
    Conserved Domains (7) summary
    smart00510
    Location:669 → 770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600 → 665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:1571 → 2083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157 → 299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:2142 → 2180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1045 → 1190
    SPOC; SPOC domain

  5. NM_177852.5 → NP_808520.2  death-inducer obliterator 1 isoform Dido2

    See identical proteins and their annotated locations for NP_808520.2

    Status: REVIEWED

    Source sequence(s)
    AL732560
    Consensus CDS
    CCDS17183.1
    UniProtKB/Swiss-Prot
    Q8C9B9
    Related
    ENSMUSP00000099346.2, ENSMUST00000103057.8
    Conserved Domains (4) summary
    smart00510
    Location:669 → 770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam01749
    Location:165 → 241
    IBB; Importin beta binding domain
    pfam07744
    Location:1052 → 1158
    SPOC; SPOC domain

RNA

  1. NR_111965.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon and contains a 3' terminal exon that extends past a splice site used in variant 3. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL732560

  2. NR_169212.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL732560

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180299757..180351886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500609.5 → XP_006500672.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006500672.1

    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Conserved Domains (7) summary
    smart00510
    Location:669 → 770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600 → 665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:1571 → 2083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157 → 299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:2142 → 2180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1045 → 1190
    SPOC; SPOC domain

  2. XM_006500615.5 → XP_006500678.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006500678.1

    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Conserved Domains (7) summary
    smart00510
    Location:669 → 770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600 → 665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:1571 → 2083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157 → 299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:2142 → 2180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1045 → 1190
    SPOC; SPOC domain

  3. XM_006500610.5 → XP_006500673.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006500673.1

    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Conserved Domains (7) summary
    smart00510
    Location:669 → 770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600 → 665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:1571 → 2083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157 → 299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:2142 → 2180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1045 → 1190
    SPOC; SPOC domain

  4. XM_006500608.5 → XP_006500671.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006500671.1

    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Conserved Domains (7) summary
    smart00510
    Location:669 → 770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600 → 665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:1571 → 2083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157 → 299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:2142 → 2180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1045 → 1190
    SPOC; SPOC domain

  5. XM_006500616.4 → XP_006500679.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006500679.1

    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Conserved Domains (7) summary
    smart00510
    Location:669 → 770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600 → 665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:1571 → 2083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157 → 299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:2142 → 2180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1045 → 1190
    SPOC; SPOC domain

  6. XM_006500611.5 → XP_006500674.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006500674.1

    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Conserved Domains (7) summary
    smart00510
    Location:669 → 770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600 → 665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:1571 → 2083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157 → 299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:2142 → 2180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1045 → 1190
    SPOC; SPOC domain

  7. XM_006500612.4 → XP_006500675.1  death-inducer obliterator 1 isoform X1

    See identical proteins and their annotated locations for XP_006500675.1

    UniProtKB/Swiss-Prot
    A2AJ47, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8C9B9, Q8CHR5, Q9WV00
    Conserved Domains (7) summary
    smart00510
    Location:669 → 770
    TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
    PRK14954
    Location:600 → 665
    PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    PHA03247
    Location:1571 → 2083
    PHA03247; large tegument protein UL36; Provisional
    COG5034
    Location:157 → 299
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    TIGR01622
    Location:2142 → 2180
    SF-CC1; splicing factor, CC1-like family
    cd15639
    Location:263 → 316
    PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
    pfam07744
    Location:1045 → 1190
    SPOC; SPOC domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C9B9.4 GenPept UniProtKB/Swiss-Prot:Q8C9B9

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