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Serpina3f serine (or cysteine) peptidase inhibitor, clade A, member 3F [ Mus musculus (house mouse) ]

Gene ID: 238393, updated on 11-Apr-2024

Summary

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Official Symbol
Serpina3fprovided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade A, member 3Fprovided by MGI
Primary source
MGI:MGI:2182838
See related
Ensembl:ENSMUSG00000066363 AllianceGenome:MGI:2182838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2A1
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to bacterium; response to cytokine; and response to peptide hormone. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 2.5), mammary gland adult (RPKM 1.4) and 14 other tissues See more
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Genomic context

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Location:
12 E; 12 53.65 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104180803..104187388)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104214544..104221129)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3D, pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3E, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4040 Neighboring gene STARR-seq mESC enhancer starr_33133 Neighboring gene developmentally regulated GTP binding protein 2 pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3G

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain. Inglis JD, et al. EMBO J, 1991 Feb. PMID 1991447, Free PMC Article
  2. Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus. Horvath AJ, et al. J Mol Evol, 2004 Oct. PMID 15638460
  3. A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins. Forsyth S, et al. Genomics, 2003 Mar. PMID 12659817
  4. APJ Regulates Parallel Alignment of Arteries and Veins in the Skin. Kidoya H, et al. Dev Cell, 2015 May 4. PMID 25920569
  5. Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. Winkler IG, et al. J Exp Med, 2005 Apr 4. PMID 15795238, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to cytokine IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to peptide hormone IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine protease inhibitor A3F
Names
alpha-1 antiproteinasin
antitrypsin
serpin A3F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033335.3 → NP_001028507.2  serine protease inhibitor A3F

    See identical proteins and their annotated locations for NP_001028507.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC142112, AK138954, BC139132
    Consensus CDS
    CCDS26149.1
    UniProtKB/Swiss-Prot
    B2RT49, Q80X76
    UniProtKB/TrEMBL
    Q3UTZ5
    Related
    ENSMUSP00000098641.2, ENSMUST00000101080.2
    Conserved Domains (1) summary
    cd02056
    Location:40 → 405
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

  2. NM_001168294.1 → NP_001161766.1  serine protease inhibitor A3F

    See identical proteins and their annotated locations for NP_001161766.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AC142112, AK138954, AK150157, BC139132
    Consensus CDS
    CCDS26149.1
    UniProtKB/Swiss-Prot
    B2RT49, Q80X76
    UniProtKB/TrEMBL
    Q3UTZ5
    Related
    ENSMUSP00000113945.2, ENSMUST00000121337.8
    Conserved Domains (1) summary
    cd02056
    Location:40 → 405
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

  3. NM_001168295.1 → NP_001161767.1  serine protease inhibitor A3F

    See identical proteins and their annotated locations for NP_001161767.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC142112, AK138954, AK150157, BC139132
    Consensus CDS
    CCDS26149.1
    UniProtKB/Swiss-Prot
    B2RT49, Q80X76
    UniProtKB/TrEMBL
    Q3UTZ5
    Related
    ENSMUSP00000126520.2, ENSMUST00000167049.8
    Conserved Domains (1) summary
    cd02056
    Location:40 → 405
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    104180803..104187388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80X76.3 GenPept UniProtKB/Swiss-Prot:Q80X76

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