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Gpr68 G protein-coupled receptor 68 [ Mus musculus (house mouse) ]

Gene ID: 238377, updated on 21-Apr-2024

Summary

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Official Symbol
Gpr68provided by MGI
Official Full Name
G protein-coupled receptor 68provided by MGI
Primary source
MGI:MGI:2441763
See related
Ensembl:ENSMUSG00000047415 AllianceGenome:MGI:2441763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ogr1
Summary
Predicted to enable G protein-coupled receptor activity. Acts upstream of or within cellular response to pH; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of myeloid leukocyte differentiation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in early conceptus; primary oocyte; and secondary oocyte. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A6. Orthologous to human GPR68 (G protein-coupled receptor 68). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 5.7), thymus adult (RPKM 5.5) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 E; 12 51.1 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (100842941..100874457, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (100876679..100908198, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33064 Neighboring gene predicted gene, 40558 Neighboring gene predicted gene, 25801 Neighboring gene D-glutamate cyclase Neighboring gene STARR-seq mESC enhancer starr_33068 Neighboring gene STARR-positive B cell enhancer ABC_E8500 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene predicted gene, 36572 Neighboring gene coiled-coil domain containing 88C Neighboring gene RIKEN cDNA A630072L19 gene Neighboring gene STARR-positive B cell enhancer ABC_E8501 Neighboring gene STARR-positive B cell enhancer ABC_E7169 Neighboring gene predicted gene, 36756 Neighboring gene STARR-seq mESC enhancer starr_33081

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GPR68 limits the severity of chemical-induced oral epithelial dysplasia. Shore D, et al. Sci Rep, 2023 Jan 7. PMID 36611126, Free PMC Article
  2. OGR1-dependent regulation of the allergen-induced asthma phenotype. Nayak AP, et al. Am J Physiol Lung Cell Mol Physiol, 2021 Dec 1. PMID 34668419, Free PMC Article
  3. GPR68 Contributes to Persistent Acidosis-Induced Activation of AGC Kinases and Tyrosine Phosphorylation in Organotypic Hippocampal Slices. Zhou G, et al. Front Neurosci, 2021. PMID 34113235, Free PMC Article
  4. RNA-Seq analysis of knocking out the neuroprotective proton-sensitive GPR68 on basal and acute ischemia-induced transcriptome changes and signaling in mouse brain. Zhou G, et al. FASEB J, 2021 Apr. PMID 33724568, Free PMC Article
  5. GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior. Xu Y, et al. Mol Brain, 2020 Sep 29. PMID 32993733, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR68 limits the severity of chemical-induced oral epithelial dysplasia.
    Title: GPR68 limits the severity of chemical-induced oral epithelial dysplasia.
  2. The orphan receptor GPR68 is expressed in the hypothalamus and is involved in the regulation of feeding.
    Title: The orphan receptor GPR68 is expressed in the hypothalamus and is involved in the regulation of feeding.
  3. OGR1-dependent regulation of the allergen-induced asthma phenotype.
    Title: OGR1-dependent regulation of the allergen-induced asthma phenotype.
  4. Extracellular acidity in tumor tissue upregulates programmed cell death protein 1 expression on tumor cells via proton-sensing G protein-coupled receptors.
    Title: Extracellular acidity in tumor tissue upregulates programmed cell death protein 1 expression on tumor cells via proton-sensing G protein-coupled receptors.
  5. The proton-activated ovarian cancer G protein-coupled receptor 1 (OGR1) is responsible for renal calcium loss during acidosis.
    Title: The proton-activated ovarian cancer G protein-coupled receptor 1 (OGR1) is responsible for renal calcium loss during acidosis.
  6. RNA-Seq analysis of knocking out the neuroprotective proton-sensitive GPR68 on basal and acute ischemia-induced transcriptome changes and signaling in mouse brain.
    Title: RNA-Seq analysis of knocking out the neuroprotective proton-sensitive GPR68 on basal and acute ischemia-induced transcriptome changes and signaling in mouse brain.
  7. GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior.
    Title: GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior.
  8. GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia.
    Title: GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia.
  9. The authors show OGR1 mediated the effects of acidic environment on proliferation, migration, and angiogenesis of endothelial progenitor cells.
    Title: OGR1 mediates the inhibitory effects of acidic environment on proliferation and angiogenesis of endothelial progenitor cells.
  10. The ability to induce OGR1 internalization and desensitization was activator dependent, reflecting the ability of different activators to induce specific receptor confirmations and engagement of specific heterotrimeric G proteins.
    Title: Regulation of ovarian cancer G protein-coupled receptor-1 expression and signaling.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to pH IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of monocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of monocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of osteoclast development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of osteoclast development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ovarian cancer G-protein coupled receptor 1
Names
sphingosylphosphorylcholine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177673.1 → NP_001171144.1  ovarian cancer G-protein coupled receptor 1

    See identical proteins and their annotated locations for NP_001171144.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC126262, AI604270, AK036659, AK087410
    Consensus CDS
    CCDS26109.1
    UniProtKB/Swiss-Prot
    Q148P7, Q3U1L3, Q80T34, Q8BFQ3
    UniProtKB/TrEMBL
    Q3U3P5
    Related
    ENSMUSP00000105692.2, ENSMUST00000110065.8
    Conserved Domains (2) summary
    pfam00001
    Location:58 → 286
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:35 → 156
    7tm_4; Olfactory receptor

  2. NM_001177674.2 → NP_001171145.1  ovarian cancer G-protein coupled receptor 1

    See identical proteins and their annotated locations for NP_001171145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC126262
    Consensus CDS
    CCDS26109.1
    UniProtKB/Swiss-Prot
    Q148P7, Q3U1L3, Q80T34, Q8BFQ3
    UniProtKB/TrEMBL
    Q3U3P5
    Related
    ENSMUSP00000057510.4, ENSMUST00000053668.10
    Conserved Domains (2) summary
    pfam00001
    Location:58 → 286
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:35 → 156
    7tm_4; Olfactory receptor

  3. NM_001403314.1 → NP_001390243.1  ovarian cancer G-protein coupled receptor 1

    Status: VALIDATED

    Source sequence(s)
    AC126262
    UniProtKB/Swiss-Prot
    Q148P7, Q3U1L3, Q80T34, Q8BFQ3

  4. NM_175493.4 → NP_780702.1  ovarian cancer G-protein coupled receptor 1

    See identical proteins and their annotated locations for NP_780702.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC126262, AI604270, AK036659
    Consensus CDS
    CCDS26109.1
    UniProtKB/Swiss-Prot
    Q148P7, Q3U1L3, Q80T34, Q8BFQ3
    UniProtKB/TrEMBL
    Q3U3P5
    Related
    ENSMUSP00000105693.2, ENSMUST00000110066.8
    Conserved Domains (2) summary
    pfam00001
    Location:58 → 286
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:35 → 156
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    100842941..100874457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFQ3.1 GenPept UniProtKB/Swiss-Prot:Q8BFQ3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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