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Cfdp1 craniofacial development protein 1 [ Mus musculus (house mouse) ]

Gene ID: 23837, updated on 5-Mar-2024

Summary

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Official Symbol
Cfdp1provided by MGI
Official Full Name
craniofacial development protein 1provided by MGI
Primary source
MGI:MGI:1344403
See related
Ensembl:ENSMUSG00000031954 AllianceGenome:MGI:1344403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bcnt; Cfdp; cp27; Bucentaur
Summary
Acts upstream of or within several processes, including cell adhesion; negative regulation of fibroblast apoptotic process; and regulation of cell shape. Predicted to be located in basement membrane. Is expressed in several structures, including 1st branchial arch; central nervous system; embryo mesenchyme; future brain; and sensory organ. Orthologous to human CFDP1 (craniofacial development protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 77.7), placenta adult (RPKM 58.1) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 57.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112493314..112580969, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111766682..111854337, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1686 Neighboring gene breast cancer anti-estrogen resistance 1 Neighboring gene predicted gene, 51589 Neighboring gene STARR-seq mESC enhancer starr_22714 Neighboring gene STARR-seq mESC enhancer starr_22715 Neighboring gene predicted gene, 39252 Neighboring gene STARR-positive B cell enhancer ABC_E6685 Neighboring gene STARR-positive B cell enhancer ABC_E6686 Neighboring gene transmembrane protein 170 Neighboring gene STARR-positive B cell enhancer ABC_E5043 Neighboring gene STARR-seq mESC enhancer starr_22724 Neighboring gene STARR-seq mESC enhancer starr_22725 Neighboring gene carbohydrate sulfotransferase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overcoming off-targets: assessing Western blot signals for Bcnt/Cfdp1, a tentative component of the chromatin remodeling complex. Iwashita S, et al. Biosci Rep, 2020 Jun 26. PMID 32432658, Free PMC Article
  2. CP27 function is necessary for cell survival and differentiation during tooth morphogenesis in organ culture. Diekwisch TG, et al. Gene, 2002 Apr 3. PMID 11992732
  3. [A novel type protein, Bcnt, that includes the region derived from a long interspersed nucleotide element]. Iwashita S. Seikagaku, 2001 Dec. PMID 11831036
  4. Gene organization of bovine BCNT that contains a portion corresponding to an endonuclease domain derived from an RTE-1 (Bov-B LINE), non-LTR retrotransposable element: duplication of an intramolecular repeat unit downstream of the truncated RTE-1. Iwashita S, et al. Gene, 2001 May 2. PMID 11368901
  5. Molecular basis of Williams-Beuren syndrome: TFII-I regulated targets involved in craniofacial development. Makeyev AV, et al. Cleft Palate Craniofac J, 2011 Jan. PMID 20500075

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overcoming off-targets: assessing Western blot signals for Bcnt/Cfdp1, a tentative component of the chromatin remodeling complex.
    Title: Overcoming off-targets: assessing Western blot signals for Bcnt/Cfdp1, a tentative component of the chromatin remodeling complex.
  2. Cfdp1 contains consensus TFII-I binding sites in the proximal promoters; the chromatin immunoprecipitation analysis showed that TFII-I transcription factors are recruited to these sites in vivo in Williams-Beuren syndrome.
    Title: Molecular basis of Williams-Beuren syndrome: TFII-I regulated targets involved in craniofacial development.
  3. These results provide a basis for our understanding of the specific regulation of the cp27 gene in the NF-Y-mediated gene transcription network.
    Title: Characterization of the mouse CP27 promoter and NF-Y mediated gene regulation.
  4. CP27 affects viability, proliferation, attachment and gene expression in embryonic fibroblasts.
    Title: CP27 affects viability, proliferation, attachment and gene expression in embryonic fibroblasts.
  5. includes the region derived from a long interspersed nucleotide
    Title: [A novel type protein, Bcnt, that includes the region derived from a long interspersed nucleotide element].
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of fibroblast apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of fibroblast apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of cell shape IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basement membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
craniofacial development protein 1
Names
27 kDa craniofacial protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368337.1 → NP_001355266.1  craniofacial development protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC127315

  2. NM_001368338.1 → NP_001355267.1  craniofacial development protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC127315

  3. NM_011801.2 → NP_035931.1  craniofacial development protein 1 isoform 1

    See identical proteins and their annotated locations for NP_035931.1

    Status: VALIDATED

    Source sequence(s)
    AC127315
    Consensus CDS
    CCDS22680.1
    UniProtKB/Swiss-Prot
    O70565, O88271, Q9JMA5
    Related
    ENSMUSP00000034432.6, ENSMUST00000034432.7
    Conserved Domains (1) summary
    pfam07572
    Location:218 → 291
    BCNT; Bucentaur or craniofacial development

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    112493314..112580969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001368335.1: Suppressed sequence

    Description
    NM_001368335.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

  2. NM_001368336.1: Suppressed sequence

    Description
    NM_001368336.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88271.1 GenPept UniProtKB/Swiss-Prot:O88271

Gene LinkOut

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