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Cdh20 cadherin 20 [ Mus musculus (house mouse) ]

Gene ID: 23836, updated on 11-Apr-2024

Summary

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Official Symbol
Cdh20provided by MGI
Official Full Name
cadherin 20provided by MGI
Primary source
MGI:MGI:1346069
See related
Ensembl:ENSMUSG00000050840 AllianceGenome:MGI:1346069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdh7
Summary
Predicted to enable cadherin binding activity and calcium ion binding activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell morphogenesis; and cell-cell junction organization. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human CDH20 (cadherin 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 5.2), frontal lobe adult (RPKM 4.8) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Cdh20 in Genome Data Viewer
Location:
1 E2.1; 1 49.42 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (104696245..104923202)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (104768340..104995481)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41924 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene phosphatidylinositol transfer protein, cytoplasmic 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01830 Neighboring gene STARR-seq mESC enhancer starr_01832 Neighboring gene STARR-seq mESC enhancer starr_01833 Neighboring gene STARR-seq mESC enhancer starr_01835 Neighboring gene STARR-seq mESC enhancer starr_01837 Neighboring gene STARR-seq mESC enhancer starr_01838 Neighboring gene predicted gene, 53576 Neighboring gene STARR-seq mESC enhancer starr_01839 Neighboring gene STARR-seq mESC enhancer starr_01840 Neighboring gene predicted gene, 41925 Neighboring gene predicted gene 29012 Neighboring gene STARR-seq mESC enhancer starr_01841 Neighboring gene ring finger protein 152 Neighboring gene predicted gene, 17634

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation. Moore R, et al. Oncogene, 2004 Sep 2. PMID 15273735
  2. Cloning and expression of mouse Cadherin-7, a type-II cadherin isolated from the developing eye. Faulkner-Jones BE, et al. Mol Cell Neurosci, 1999 Jul. PMID 10433813
  3. Comparative analysis of type II classic cadherin mRNA distribution patterns in the developing and adult mouse somatosensory cortex and hippocampus suggests significant functional redundancy. Lefkovics K, et al. J Comp Neurol, 2012 May 1. PMID 22102170
  4. A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. Ding Y, et al. Elife, 2022 Oct 18. PMID 36255053, Free PMC Article
  5. GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools. Haase G, et al. Neuron, 2002 Aug 29. PMID 12372284

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Melanoma cell lines contained transcripts for cadherin-7 but not for cadherin-20.
    Title: Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC141415

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cadherin-20
Names
cadherin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420677.1 → NP_001407606.1  cadherin-20 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC101970, AC124447, AC158931

  2. NM_011800.6 → NP_035930.1  cadherin-20 isoform 1 precursor

    See identical proteins and their annotated locations for NP_035930.1

    Status: VALIDATED

    Source sequence(s)
    AC101970, AC124447, AC158931
    Consensus CDS
    CCDS15203.1
    UniProtKB/Swiss-Prot
    Q9Z0M3
    Related
    ENSMUSP00000052078.9, ENSMUST00000062528.9
    Conserved Domains (3) summary
    cd11304
    Location:394 → 490
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:85 → 163
    CA; Cadherin repeats
    pfam01049
    Location:643 → 794
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    104696245..104923202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0M3.1 GenPept UniProtKB/Swiss-Prot:Q9Z0M3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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