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Cdc6 cell division cycle 6 [ Mus musculus (house mouse) ]

Gene ID: 23834, updated on 5-Mar-2024

Summary

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Official Symbol
Cdc6provided by MGI
Official Full Name
cell division cycle 6provided by MGI
Primary source
MGI:MGI:1345150
See related
Ensembl:ENSMUSG00000017499 AllianceGenome:MGI:1345150
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDC18L; p62(cdc6)
Summary
Enables chromatin binding activity. Predicted to be involved in several processes, including positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of fibroblast proliferation; and regulation of cell cycle process. Predicted to act upstream of or within DNA replication and cell division. Located in cytoplasm and spindle. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 13.4), liver E14.5 (RPKM 11.7) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Cdc6 in Genome Data Viewer
Location:
11 62.74 cM; 11 D
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98798627..98814768)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98907709..98923942)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF)-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E9145 Neighboring gene WAS/WASL interacting protein family, member 2 Neighboring gene VISTA enhancer mm1323 Neighboring gene STARR-positive B cell enhancer ABC_E203 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98803426-98803613 Neighboring gene retinoic acid receptor, alpha Neighboring gene STARR-positive B cell enhancer ABC_E9373 Neighboring gene predicted gene, 46294 Neighboring gene predicted gene, 22061

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization. Kumar R, et al. Arterioscler Thromb Vasc Biol, 2022 Apr. PMID 35236105, Free PMC Article
  2. CDC6 regulates both G2/M transition and metaphase-to-anaphase transition during the first meiosis of mouse oocytes. Yi ZY, et al. J Cell Physiol, 2020 Jul. PMID 31984513
  3. Cdc6 protein obstructs apoptosome assembly and consequent cell death by forming stable complexes with activated Apaf-1 molecules. Niimi S, et al. J Biol Chem, 2012 May 25. PMID 22493447, Free PMC Article
  4. CDC6 requirement for spindle formation during maturation of mouse oocytes. Anger M, et al. Biol Reprod, 2005 Jan. PMID 15385409
  5. Identification and characterization of a mouse homolog to yeast Cdc6p. Berger C, et al. Cytogenet Cell Genet, 1999. PMID 10575231

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization.
    Title: Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization.
  2. CDC6 regulates both G2/M transition and metaphase-to-anaphase transition during the first meiosis of mouse oocytes.
    Title: CDC6 regulates both G2/M transition and metaphase-to-anaphase transition during the first meiosis of mouse oocytes.
  3. Dele and Cdc6 G-quadruplex formation is significant in the transcriptional regulation. Dele and Cdc6 G-quadruplex DNA alone possess enhancer and promotor function.
    Title: Identification of G-quadruplex structures that possess transcriptional regulating functions in the Dele and Cdc6 CpG islands.
  4. CDK1 activation proceeds with concomitant inhibition by CDC6, which tunes the timing of the M-phase entry during the embryonic cell cycle
    Title: CDC6 controls dynamics of the first embryonic M-phase entry and progression via CDK1 inhibition.
  5. Cdc6 continued to block apoptosome assembly induced by a non-cytochrome c or some other mechanism, suppressing seemingly unintended apoptosis when promoting cell proliferation
    Title: Cdc6 protein obstructs apoptosome assembly and consequent cell death by forming stable complexes with activated Apaf-1 molecules.
  6. show that MyoD can occupy an E-box within the promoter of Cdc6 and that this association, along with E2F3a, is required for its activity.
    Title: Activation of Cdc6 by MyoD is associated with the expansion of quiescent myogenic satellite cells.
  7. hCdt1 and hCdc6 expression promote malignant behavior
    Title: Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.
  8. CDC6 is essential for spindle formation in mouse oocytes
    Title: CDC6 requirement for spindle formation during maturation of mouse oocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle midzone ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell division control protein 6 homolog
Names
CDC6-related protein
cell division cycle 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025779.2 → NP_001020950.1  cell division control protein 6 homolog isoform b

    See identical proteins and their annotated locations for NP_001020950.1

    Status: VALIDATED

    Source sequence(s)
    AL591067, BC052434
    Consensus CDS
    CCDS25368.1
    UniProtKB/Swiss-Prot
    O89033, Q3TMD0, Q8C3S5, Q9CZT0
    Related
    ENSMUSP00000090382.7, ENSMUST00000092706.13
    Conserved Domains (3) summary
    smart01074
    Location:467 → 547
    Cdc6_C; CDC6, C terminal
    COG1474
    Location:170 → 547
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam13191
    Location:173 → 314
    AAA_16; AAA ATPase domain

  2. NM_001362735.1 → NP_001349664.1  cell division control protein 6 homolog isoform c

    Status: VALIDATED

    Source sequence(s)
    AL591067
    Conserved Domains (1) summary
    COG1474
    Location:170 → 546
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]

  3. NM_011799.2 → NP_035929.1  cell division control protein 6 homolog isoform a

    See identical proteins and their annotated locations for NP_035929.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AJ223087, AL591067
    Consensus CDS
    CCDS25367.1
    UniProtKB/TrEMBL
    A0A0R4J145
    Related
    ENSMUSP00000091469.3, ENSMUST00000093937.3
    Conserved Domains (3) summary
    smart01074
    Location:494 → 574
    Cdc6_C; CDC6, C terminal
    COG1474
    Location:197 → 574
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam13191
    Location:200 → 341
    AAA_16; AAA ATPase domain

RNA

  1. NR_156128.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK162669, AL591067, CO041455
    Related
    ENSMUST00000133779.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98798627..98814768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O89033.2 GenPept UniProtKB/Swiss-Prot:O89033

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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