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Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 [ Mus musculus (house mouse) ]

Gene ID: 23827, updated on 20-Apr-2024

Summary

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Official Symbol
Bpnt1provided by MGI
Official Full Name
3'(2'), 5'-bisphosphate nucleotidase 1provided by MGI
Primary source
MGI:MGI:1338800
See related
Ensembl:ENSMUSG00000026617 AllianceGenome:MGI:1338800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BPntase
Summary
Enables 3'(2'),5'-bisphosphate nucleotidase activity. Predicted to be involved in inositol phosphate dephosphorylation and phosphatidylinositol phosphate biosynthetic process. Is expressed in apical ectodermal ridge and limb. Orthologous to human BPNT1 (3'(2'), 5'-bisphosphate nucleotidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 27.7), kidney adult (RPKM 26.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H5; 1 89.49 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (185061619..185089974)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (185329428..185357777)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene isoleucine-tRNA synthetase 2, mitochondrial Neighboring gene RIKEN cDNA 2010103J01 gene Neighboring gene microRNA 194-1 Neighboring gene microRNA 215 Neighboring gene STARR-seq mESC enhancer starr_03326 Neighboring gene STARR-seq mESC enhancer starr_03328 Neighboring gene STARR-positive B cell enhancer ABC_E4403 Neighboring gene STARR-positive B cell enhancer ABC_E3350 Neighboring gene glutamyl-prolyl-tRNA synthetase 1 Neighboring gene RIKEN cDNA 9630028B13 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis. Hudson BH, et al. Proc Natl Acad Sci U S A, 2018 Mar 20. PMID 29507250, Free PMC Article
  2. Tissue-specific regulation of 3'-nucleotide hydrolysis and nucleolar architecture. Hudson BH, et al. Adv Biol Regul, 2014 Jan. PMID 24309248, Free PMC Article
  3. Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice. Hale AT, et al. Adv Biol Regul, 2020 May. PMID 32019729, Free PMC Article
  4. Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis. Hudson BH, et al. Proc Natl Acad Sci U S A, 2013 Mar 26. PMID 23479625, Free PMC Article
  5. Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. Spiegelberg BD, et al. J Biol Chem, 1999 May 7. PMID 10224133

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'(2'),5'-bisphosphate nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'(2'),5'-bisphosphate nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3'(2'),5'-bisphosphate nucleotidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-1,4-bisphosphate 1-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3'(2'),5'-bisphosphate nucleotidase 1
Names
3'-phosphoadenosine 5'-phosphate phosphatase
BPntase 1
PAP phosphatase
PAP-inositol 1,4-phosphatase
PIP
bisphosphate 3'-nucleotidase 1
inositol-polyphosphate 1-phosphatase
NP_001334139.1
NP_001334141.1
NP_035924.2
XP_006497223.1
XP_006497224.1
XP_030109781.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347210.1 → NP_001334139.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129195
    Consensus CDS
    CCDS83657.1
    UniProtKB/TrEMBL
    A0A1B0GRV0, Q3UBN8
    Related
    ENSMUSP00000147674.2, ENSMUST00000210277.2
    Conserved Domains (1) summary
    cd01640
    Location:11 → 311
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

  2. NM_001347212.1 → NP_001334141.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC129195
    Consensus CDS
    CCDS83658.1
    UniProtKB/TrEMBL
    D3Z0E6, Q3UBN8
    Related
    ENSMUSP00000106590.2, ENSMUST00000110965.2

  3. NM_011794.3 → NP_035924.2  3'(2'),5'-bisphosphate nucleotidase 1 isoform 1

    See identical proteins and their annotated locations for NP_035924.2

    Status: VALIDATED

    Source sequence(s)
    AC129195
    Consensus CDS
    CCDS15597.1
    UniProtKB/Swiss-Prot
    Q3U8Z5, Q91XB9, Q9D7Y0, Q9Z0S1
    UniProtKB/TrEMBL
    Q3UBN8
    Related
    ENSMUSP00000027916.7, ENSMUST00000027916.13
    Conserved Domains (1) summary
    cd01640
    Location:11 → 296
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    185061619..185089974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497160.5 → XP_006497223.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006497223.1

    UniProtKB/TrEMBL
    A0A1B0GRV0, Q3UBN8
    Conserved Domains (1) summary
    cd01640
    Location:11 → 311
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

  2. XM_030253921.2 → XP_030109781.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3U8Z5, Q91XB9, Q9D7Y0, Q9Z0S1
    UniProtKB/TrEMBL
    Q3UBN8
    Conserved Domains (1) summary
    cd01640
    Location:11 → 296
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

  3. XM_006497161.5 → XP_006497224.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X3

    UniProtKB/TrEMBL
    Q3UBN8
    Conserved Domains (1) summary
    cd01640
    Location:1 → 256
    IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0S1.2 GenPept UniProtKB/Swiss-Prot:Q9Z0S1

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