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Gpr135 G protein-coupled receptor 135 [ Mus musculus (house mouse) ]

Gene ID: 238252, updated on 11-Apr-2024

Summary

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Official Symbol
Gpr135provided by MGI
Official Full Name
G protein-coupled receptor 135provided by MGI
Primary source
MGI:MGI:2676315
See related
Ensembl:ENSMUSG00000043398 AllianceGenome:MGI:2676315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAFR
Summary
Predicted to enable G protein-coupled receptor activity and arrestin family protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endosome and plasma membrane. Orthologous to human GPR135 (G protein-coupled receptor 135). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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See Gpr135 in Genome Data Viewer
Location:
12 C3; 12 30.2 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (72114748..72117875, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (72067974..72071101, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40440 Neighboring gene STARR-seq mESC enhancer starr_32432 Neighboring gene predicted gene 7986 Neighboring gene L-3-hydroxyproline dehydratase (trans-) Neighboring gene predicted gene 3225 Neighboring gene STARR-seq mESC enhancer starr_32433 Neighboring gene STARR-positive B cell enhancer ABC_E3055 Neighboring gene JNK1/MAPK8-associated membrane protein Neighboring gene predicted gene, 19135

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. Fredriksson R, et al. FEBS Lett, 2003 Nov 20. PMID 14623098
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arrestin family protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 135
Names
probable G-protein coupled receptor 135

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181752.2 → NP_861417.1  G-protein coupled receptor 135

    See identical proteins and their annotated locations for NP_861417.1

    Status: VALIDATED

    Source sequence(s)
    BC062104, CR974486
    Consensus CDS
    CCDS25965.1
    UniProtKB/Swiss-Prot
    Q7TQP2
    UniProtKB/TrEMBL
    A3KMD9, A7E1Z8, Q1LZL6
    Related
    ENSMUSP00000058762.5, ENSMUST00000050649.6
    Conserved Domains (2) summary
    pfam00001
    Location:89 → 350
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl10012
    Location:251 → 282
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    72114748..72117875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TQP2.1 GenPept UniProtKB/Swiss-Prot:Q7TQP2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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