Banf1 BAF nuclear assembly factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Banf1provided by MGI
Official Full Name: BAF nuclear assembly factor 1provided by MGI
Primary source: MGI:MGI:1346330
See related: Ensembl:ENSMUSG00000024844 AllianceGenome:MGI:1346330
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Baf; Bcrp1; L2bp1/Baf
Summary: Enables DNA binding activity. Acts upstream of or within DNA integration. Predicted to be located in condensed chromosome; cytosol; and nucleus. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in progeria. Orthologous to human BANF1 (BAF nuclear assembly factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 59.0), liver E14 (RPKM 55.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.31 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (5414661..5416904, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (5364633..5366876, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BANF1 promotes glutamate-induced apoptosis of HT-22 hippocampal neurons.
Title: BANF1 promotes glutamate-induced apoptosis of HT-22 hippocampal neurons.
Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response.
Title: Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response.
BAF can act in a phosphorylation-regulated manner to impair HSV-1 transcription and/or DNA replication.
Title: Barrier to auto integration factor becomes dephosphorylated during HSV-1 Infection and Can Act as a host defense by impairing viral DNA replication and gene expression.
Data determined that the knockdown of Banf1 alters the cell cycle distribution of both human and mouse ESCs by causing an uncharacteristic increase in the proportion of cells in the G2-M phase of the cell cycle.
Title: Banf1 is required to maintain the self-renewal of both mouse and human embryonic stem cells.
Results suggest that Bcrp1 and P-gp transport topotecan into vCSF and out of brain parenchyma through the blood-brain barrier, and findings may help to improve pharmacologic strategies to treat brain tumors.
Title: Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid.
HB and barrier-to-autointegration factor are the same protein
Title: Identification of the autoantigen HB as the barrier-to-autointegration factor.
LAP2alpha stabilizes the association of BAF with the PIC to stimulate intermolecular integration and suppress autointegration.
Title: LAP2alpha and BAF collaborate to organize the Moloney murine leukemia virus preintegration complex.
testicular cells display a 'Side Population' that express Bcrp1 mRNA, the ABC transporter responsible for Hoechst efflux in hematopoietic cells
Title: 'Side Population' cells in adult mouse testis express Bcrp1 gene and are enriched in spermatogonia and germinal stem cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA integration	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromosome organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of integrated proviral latency	TAS Traceable Author Statement more info	PubMed
involved_in mitotic nuclear membrane reassembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cGAS/STING signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in condensed chromosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in condensed chromosome	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: barrier-to-autointegration factor

Names: LAP2-binding protein 1; barrier to autointegration factor 1; breakpoint cluster region protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038231.2 → NP_001033320.1 barrier-to-autointegration factor

See identical proteins and their annotated locations for NP_001033320.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 1-3 encode the same protein.

Source sequence(s)

AC122861, AK010257

Consensus CDS

CCDS29458.1

UniProtKB/Swiss-Prot

O54962, Q542E6

Related

ENSMUSP00000126202.2, ENSMUST00000170010.3

Conserved Domains (1) summary

pfam02961
Location:1 → 86

BAF; Barrier to autointegration factor
NM_001286608.1 → NP_001273537.1 barrier-to-autointegration factor

See identical proteins and their annotated locations for NP_001273537.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the functional protein. Variants 1-3 encode the same protein.

Source sequence(s)

AC122861, AK011079, BE863097, BY111854

Consensus CDS

CCDS29458.1

UniProtKB/Swiss-Prot

O54962, Q542E6

Related

ENSMUSP00000158117.2, ENSMUST00000237167.2

Conserved Domains (1) summary

pfam02961
Location:1 → 86

BAF; Barrier to autointegration factor
NM_011793.3 → NP_035923.1 barrier-to-autointegration factor

See identical proteins and their annotated locations for NP_035923.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1-3 encode the same protein.

Source sequence(s)

AC122861, AK011079, BE863097

Consensus CDS

CCDS29458.1

UniProtKB/Swiss-Prot

O54962, Q542E6

Related

ENSMUSP00000025762.9, ENSMUST00000025762.16

Conserved Domains (1) summary

pfam02961
Location:1 → 86

BAF; Barrier to autointegration factor

RNA

NR_104482.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice site in the 5'-terminal exon and lacks an internal exon, compared to variant 3. This variant is represented as non-coding because it lacks a significant portion of the coding region and does not encode a supported protein.

Source sequence(s)

AC122861, AK011079, BE863097

Related

ENSMUST00000237704.2