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Cog5 component of oligomeric golgi complex 5 [ Mus musculus (house mouse) ]

Gene ID: 238123, updated on 11-Apr-2024

Summary

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Official Symbol
Cog5provided by MGI
Official Full Name
component of oligomeric golgi complex 5provided by MGI
Primary source
MGI:MGI:2145130
See related
Ensembl:ENSMUSG00000035933 AllianceGenome:MGI:2145130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GTC90; GOLTC1; 5430405C01Rik
Summary
Predicted to be involved in intra-Golgi vesicle-mediated transport. Predicted to act upstream of or within inter-Golgi cisterna vesicle-mediated transport. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIi. Orthologous to human COG5 (component of oligomeric golgi complex 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 11.7), mammary gland adult (RPKM 11.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 A3; 12 13.68 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (31704848..31987629)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (31654819..31937630)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene B cell receptor associated protein 29 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:32339618-32339801 Neighboring gene STARR-seq mESC enhancer starr_31859 Neighboring gene dihydrouridine synthase 4 like Neighboring gene STARR-seq mESC enhancer starr_31862 Neighboring gene G protein-coupled receptor 22 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_31865 Neighboring gene predicted gene, 25913 Neighboring gene predicted gene, 35666 Neighboring gene STARR-positive B cell enhancer ABC_E79 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:32658358-32658559 Neighboring gene high mobility group box transcription factor 1 Neighboring gene protein kinase, cAMP dependent regulatory, type II beta Neighboring gene STARR-positive B cell enhancer ABC_E4024 Neighboring gene predicted gene, 53716 Neighboring gene STARR-seq mESC enhancer starr_31869 Neighboring gene predicted gene, 51992

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inter-Golgi cisterna vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, vesicle recycling within Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of Golgi transport complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Golgi transport complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
conserved oligomeric Golgi complex subunit 5
Names
COG complex subunit 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163126.1 → NP_001156598.1  conserved oligomeric Golgi complex subunit 5

    See identical proteins and their annotated locations for NP_001156598.1

    Status: VALIDATED

    Source sequence(s)
    AK030656, BM244396, CA316530, CA580184, CX240209
    Consensus CDS
    CCDS49046.1
    UniProtKB/Swiss-Prot
    E9QM30, Q8C0L8
    Related
    ENSMUSP00000044797.5, ENSMUST00000036862.5
    Conserved Domains (1) summary
    pfam10392
    Location:35 → 158
    COG5; Golgi transport complex subunit 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    31704848..31987629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515084.5 → XP_006515147.1  conserved oligomeric Golgi complex subunit 5 isoform X2

    Conserved Domains (1) summary
    pfam10392
    Location:35 → 158
    COG5; Golgi transport complex subunit 5

  2. XM_006515083.3 → XP_006515146.1  conserved oligomeric Golgi complex subunit 5 isoform X1

    Conserved Domains (1) summary
    pfam10392
    Location:35 → 158
    COG5; Golgi transport complex subunit 5

  3. XM_017315052.3 → XP_017170541.1  conserved oligomeric Golgi complex subunit 5 isoform X3

    Conserved Domains (1) summary
    cl00549
    Location:360 → 464
    ABC_membrane; ABC transporter transmembrane region

  4. XM_011243869.4 → XP_011242171.1  conserved oligomeric Golgi complex subunit 5 isoform X3

    Conserved Domains (1) summary
    cl00549
    Location:360 → 464
    ABC_membrane; ABC transporter transmembrane region

  5. XM_017315053.3 → XP_017170542.1  conserved oligomeric Golgi complex subunit 5 isoform X4

    Conserved Domains (1) summary
    cl00549
    Location:306 → 410
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0L8.3 GenPept UniProtKB/Swiss-Prot:Q8C0L8

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