Apc2 APC regulator of WNT signaling pathway 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apc2provided by MGI
Official Full Name: APC regulator of WNT signaling pathway 2provided by MGI
Primary source: MGI:MGI:1346052
See related: Ensembl:ENSMUSG00000020135 AllianceGenome:MGI:1346052
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: APCL
Summary: Predicted to enable beta-catenin binding activity; gamma-catenin binding activity; and microtubule binding activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of canonical Wnt signaling pathway; and negative regulation of microtubule depolymerization. Predicted to be located in several cellular components, including cytoskeleton; lamellipodium membrane; and midbody. Predicted to be part of beta-catenin destruction complex; catenin complex; and filamentous actin. Predicted to colocalize with cytoplasmic microtubule. Is expressed in several structures, including appendicular skeleton; axial skeleton; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Sotos syndrome 3 and complex cortical dysplasia with other brain malformations. Orthologous to human APC2 (APC regulator of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 41.1), CNS E14 (RPKM 27.7) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (80131790..80154091)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (80295956..80318257)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This work adds APC2 to the growing list of WNT-signalling members that regulate ovarian homeostasis, fertility and suppress granulosa cell tumour formation.
Title: APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression.
Authors show that systemic loss of Apc2 results in an increase in the number of cells displaying nuclear beta-catenin at the base of the intestinal crypt. This subsequently impacts the expression levels of several ISC markers and the fitness of ISCs as assessed by organoid formation efficiency.
Title: Subtle Deregulation of the Wnt-Signaling Pathway Through Loss of Apc2 Reduces the Fitness of Intestinal Stem Cells.
Lack of adenomatosis polyposis coli 2 induces severe laminary defects in some regions of the mouse brain, including the cerebral cortex and cerebellum.
Title: Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
This study provided genetic evidence that APC/C activity in the adult forebrain is required for cognitive function.
Title: The anaphase promoting complex is required for memory function in mice.
Apc2 is expressed in post-mitotic cells and may contribute to the development of neuronal cells
Title: Expression of Apc2 during mouse development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125236 (e-PCR)
- UniSTS:162058

Apc2 (e-PCR), detects polymorphism
- UniSTS:532263

AI852447 (e-PCR)
- UniSTS:180074

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables gamma-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in pattern specification process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
part_of beta-catenin destruction complex	IBA Inferred from Biological aspect of Ancestor more info
part_of beta-catenin destruction complex	NAS Non-traceable Author Statement more info	PubMed
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in lamellipodium membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenomatous polyposis coli protein 2

Names: adenomatosis polyposis coli 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001372237.1 → NP_001359166.1 adenomatous polyposis coli protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC140229, AC152062

Consensus CDS

CCDS88053.1

UniProtKB/Swiss-Prot

Q9Z1K7

UniProtKB/TrEMBL

D3YTR0

Related

ENSMUSP00000100996.2, ENSMUST00000105359.8

Conserved Domains (10) summary

PTZ00449
Location:2028 → 2225

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00185
Location:636 → 676

ARM; Armadillo/beta-catenin-like repeats

PHA03247
Location:1534 → 1973

PHA03247; large tegument protein UL36; Provisional

sd00043
Location:549 → 582

ARM; armadillo repeat [structural motif]

pfam05923
Location:1399 → 1421

APC_r; APC repeat

pfam05956
Location:1786 → 2111

APC_basic; APC basic domain

pfam11414
Location:148 → 228

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:719 → 965

Arm_APC_u3; Armadillo-associated region on APC

pfam16689
Location:30 → 81

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam18797
Location:380 → 453

APC_rep; Adenomatous polyposis coli (APC) repeat
NM_001372238.1 → NP_001359167.1 adenomatous polyposis coli protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC140229, AC152062

UniProtKB/Swiss-Prot

Q9Z1K7

Conserved Domains (10) summary

PTZ00449
Location:2029 → 2226

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00185
Location:637 → 677

ARM; Armadillo/beta-catenin-like repeats

PHA03247
Location:1535 → 1974

PHA03247; large tegument protein UL36; Provisional

sd00043
Location:550 → 583

ARM; armadillo repeat [structural motif]

pfam05923
Location:1400 → 1422

APC_r; APC repeat

pfam05956
Location:1787 → 2112

APC_basic; APC basic domain

pfam11414
Location:148 → 229

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:720 → 966

Arm_APC_u3; Armadillo-associated region on APC

pfam16689
Location:30 → 81

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam18797
Location:381 → 454

APC_rep; Adenomatous polyposis coli (APC) repeat
NM_001372239.1 → NP_001359168.1 adenomatous polyposis coli protein 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC140229, AC152062

UniProtKB/Swiss-Prot

Q9Z1K7

Conserved Domains (10) summary

PTZ00449
Location:2004 → 2201

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00185
Location:612 → 652

ARM; Armadillo/beta-catenin-like repeats

PHA03247
Location:1510 → 1949

PHA03247; large tegument protein UL36; Provisional

sd00043
Location:525 → 558

ARM; armadillo repeat [structural motif]

pfam05923
Location:1375 → 1397

APC_r; APC repeat

pfam05956
Location:1762 → 2087

APC_basic; APC basic domain

pfam11414
Location:124 → 204

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:695 → 941

Arm_APC_u3; Armadillo-associated region on APC

pfam16689
Location:6 → 57

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam18797
Location:356 → 429

APC_rep; Adenomatous polyposis coli (APC) repeat
NM_001372240.1 → NP_001359169.1 adenomatous polyposis coli protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC140229, AC152062

UniProtKB/Swiss-Prot

Q9Z1K7

Conserved Domains (10) summary

PTZ00449
Location:2042 → 2239

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00185
Location:650 → 690

ARM; Armadillo/beta-catenin-like repeats

PHA03247
Location:1548 → 1987

PHA03247; large tegument protein UL36; Provisional

sd00043
Location:563 → 596

ARM; armadillo repeat [structural motif]

pfam05923
Location:1413 → 1435

APC_r; APC repeat

pfam05956
Location:1800 → 2125

APC_basic; APC basic domain

pfam11414
Location:161 → 242

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:733 → 979

Arm_APC_u3; Armadillo-associated region on APC

pfam16689
Location:43 → 94

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam18797
Location:394 → 467

APC_rep; Adenomatous polyposis coli (APC) repeat
NM_001372241.1 → NP_001359170.1 adenomatous polyposis coli protein 2 isoform 6

Status: VALIDATED

Source sequence(s)

AC140229, AC152062

UniProtKB/Swiss-Prot

Q9Z1K7

Conserved Domains (10) summary

PTZ00449
Location:2041 → 2238

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00185
Location:649 → 689

ARM; Armadillo/beta-catenin-like repeats

PHA03247
Location:1547 → 1986

PHA03247; large tegument protein UL36; Provisional

sd00043
Location:562 → 595

ARM; armadillo repeat [structural motif]

pfam05923
Location:1412 → 1434

APC_r; APC repeat

pfam05956
Location:1799 → 2124

APC_basic; APC basic domain

pfam11414
Location:161 → 241

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:732 → 978

Arm_APC_u3; Armadillo-associated region on APC

pfam16689
Location:43 → 94

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam18797
Location:393 → 466

APC_rep; Adenomatous polyposis coli (APC) repeat
NM_011789.2 → NP_035919.2 adenomatous polyposis coli protein 2 isoform 5

See identical proteins and their annotated locations for NP_035919.2

Status: VALIDATED

Source sequence(s)

AC140229, AC152062

Consensus CDS

CCDS24016.1

UniProtKB/Swiss-Prot

Q9Z1K7

UniProtKB/TrEMBL

G5E832

Related

ENSMUSP00000020349.7, ENSMUST00000020349.7

Conserved Domains (8) summary

cd00020
Location:569 → 687

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam05923
Location:1370 → 1394

APC_crr; APC cysteine-rich region

pfam05924
Location:1595 → 1613

SAMP; SAMP Motif

pfam05956
Location:1757 → 2082

APC_basic; APC basic domain

pfam11414
Location:124 → 204

Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

pfam16629
Location:690 → 936

Arm_APC_u3; Armadillo-associated region on APC

pfam16689
Location:6 → 57

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

sd00043
Location:520 → 553

ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

80131790..80154091

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513646.5 → XP_006513709.1 adenomatous polyposis coli protein 2 isoform X1

UniProtKB/Swiss-Prot

Q9Z1K7

Conserved Domains (10) summary

PTZ00449
Location:2005 → 2202

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00185
Location:613 → 653

ARM; Armadillo/beta-catenin-like repeats

PHA03247
Location:1511 → 1950

PHA03247; large tegument protein UL36; Provisional

sd00043
Location:526 → 559

ARM; armadillo repeat [structural motif]

pfam05923
Location:1376 → 1398

APC_r; APC repeat

pfam05956
Location:1763 → 2088

APC_basic; APC basic domain

pfam11414
Location:124 → 205

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:696 → 942

Arm_APC_u3; Armadillo-associated region on APC

pfam16689
Location:6 → 57

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam18797
Location:357 → 430

APC_rep; Adenomatous polyposis coli (APC) repeat