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Wdcp WD repeat and coiled coil containing [ Mus musculus (house mouse) ]

Gene ID: 238037, updated on 5-Mar-2024

Summary

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Official Symbol
Wdcpprovided by MGI
Official Full Name
WD repeat and coiled coil containingprovided by MGI
Primary source
MGI:MGI:3040699
See related
Ensembl:ENSMUSG00000051721 AllianceGenome:MGI:3040699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A430092C04
Summary
Predicted to enable kinase binding activity. Predicted to be involved in protein complex oligomerization. Orthologous to human WDCP (WD repeat and coiled coil containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 2.7), CNS E11.5 (RPKM 2.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 A1.1; 12 2.1 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4892384..4910049)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4842351..4860049)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8478 Neighboring gene splicing factor 3B, subunit 6 Neighboring gene FK506 binding protein 1b Neighboring gene STARR-positive B cell enhancer ABC_E4023 Neighboring gene MFSD2 lysolipid transporter B, sphingolipid Neighboring gene UBX domain protein 2A Neighboring gene STARR-seq mESC enhancer starr_31460

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  2. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
WD repeat and coiled-coil-containing protein
Names
WD repeat and coiled-coil-containing protein C2orf44 homolog
WD repeat-containing protein C2orf44 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170858.1 → NP_001164329.1  WD repeat and coiled-coil-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001164329.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    CT571254
    Consensus CDS
    CCDS49019.1
    UniProtKB/Swiss-Prot
    Q3U2S5, Q6NV72, Q8C9V8
    UniProtKB/TrEMBL
    A0A1W2P880
    Related
    ENSMUSP00000151585.2, ENSMUST00000220215.2
    Conserved Domains (1) summary
    pfam15390
    Location:2 → 637
    WDCP; WD repeat and coiled-coil-containing protein family

  2. NM_001422811.1 → NP_001409740.1  WD repeat and coiled-coil-containing protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT571254
    UniProtKB/TrEMBL
    A0A1Y7VJP4

  3. NM_173416.3 → NP_775592.2  WD repeat and coiled-coil-containing protein isoform 2

    See identical proteins and their annotated locations for NP_775592.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 3' coding region and 3' UTR versus variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    CT571254
    Consensus CDS
    CCDS25793.1
    UniProtKB/TrEMBL
    A0A1W2P880
    Related
    ENSMUSP00000054102.5, ENSMUST00000053034.6
    Conserved Domains (1) summary
    pfam15390
    Location:2 → 603
    DUF4613; Domain of unknown function (DUF4613)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    4892384..4910049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315049.3 → XP_017170538.1  WD repeat and coiled-coil-containing protein isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VJP4
    Conserved Domains (1) summary
    pfam15390
    Location:2 → 664
    WDCP; WD repeat and coiled-coil-containing protein family

  2. XM_036157388.1 → XP_036013281.1  WD repeat and coiled-coil-containing protein isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VJP4
    Conserved Domains (1) summary
    pfam15390
    Location:2 → 664
    WDCP; WD repeat and coiled-coil-containing protein family

  3. XM_036157390.1 → XP_036013283.1  WD repeat and coiled-coil-containing protein isoform X3

    UniProtKB/TrEMBL
    A0A1W2P880
    Conserved Domains (1) summary
    pfam15390
    Location:2 → 601
    WDCP; WD repeat and coiled-coil-containing protein family

  4. XM_036157389.1 → XP_036013282.1  WD repeat and coiled-coil-containing protein isoform X2

    UniProtKB/Swiss-Prot
    Q3U2S5, Q6NV72, Q8C9V8
    UniProtKB/TrEMBL
    A0A1W2P880
    Conserved Domains (1) summary
    pfam15390
    Location:2 → 637
    WDCP; WD repeat and coiled-coil-containing protein family

  5. XM_017315048.3 → XP_017170537.1  WD repeat and coiled-coil-containing protein isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VJP4
    Conserved Domains (1) summary
    pfam15390
    Location:2 → 664
    WDCP; WD repeat and coiled-coil-containing protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NV72.2 GenPept UniProtKB/Swiss-Prot:Q6NV72

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