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Fn3krp fructosamine 3 kinase related protein [ Mus musculus (house mouse) ]

Gene ID: 238024, updated on 11-Apr-2024

Summary

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Official Symbol
Fn3krpprovided by MGI
Official Full Name
fructosamine 3 kinase related proteinprovided by MGI
Primary source
MGI:MGI:2679256
See related
Ensembl:ENSMUSG00000039253 AllianceGenome:MGI:2679256
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FN3K-RP
Summary
Predicted to enable kinase activity. Is expressed in liver. Orthologous to human FN3KRP (fructosamine 3 kinase related protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 15.4), liver E14.5 (RPKM 15.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Fn3krp in Genome Data Viewer
Location:
11 E2; 11 85.37 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (121312199..121322114)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121421373..121431288)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 45B Neighboring gene STARR-seq mESC enhancer starr_31380 Neighboring gene Rab40B, member RAS oncogene family Neighboring gene microRNA 7236 Neighboring gene STARR-positive B cell enhancer mm9_chr11:121282511-121282812 Neighboring gene STARR-positive B cell enhancer mm9_chr11:121312999-121313300 Neighboring gene fructosamine 3 kinase Neighboring gene tubulin-specific chaperone d Neighboring gene STARR-seq mESC enhancer starr_31381 Neighboring gene zinc finger protein 750

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines. Collard F, et al. Diabetes, 2003 Dec. PMID 14633848
  2. Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein. Delplanque J, et al. J Biol Chem, 2004 Nov 5. PMID 15331600
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. fructosamine 3-kinase and fructosamine 3-kinase-related protein have roles in repairing damage caused by ribose 5-phosphate
    Title: Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC40640

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-ribulosamine 3-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
ketosamine-3-kinase
Names
FN3K-related protein
ortholog of human fructosamine-3-kinase-related protein FN3KRP
protein-psicosamine 3-kinase FN3KRP
NP_852085.2
XP_006533337.1
XP_036012573.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181420.3 → NP_852085.2  ketosamine-3-kinase

    See identical proteins and their annotated locations for NP_852085.2

    Status: VALIDATED

    Source sequence(s)
    AL663088
    Consensus CDS
    CCDS25775.1
    UniProtKB/Swiss-Prot
    B1ATT5, Q8K274
    Related
    ENSMUSP00000038061.8, ENSMUST00000038096.8
    Conserved Domains (1) summary
    cl21453
    Location:21 → 307
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    121312199..121322114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533274.1 → XP_006533337.1  ketosamine-3-kinase isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:21 → 324
    PKc_like; Protein Kinases, catalytic domain

  2. XM_036156680.1 → XP_036012573.1  ketosamine-3-kinase isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:48 → 198
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K274.2 GenPept UniProtKB/Swiss-Prot:Q8K274

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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