Sppl2c signal peptide peptidase 2C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sppl2cprovided by MGI
Official Full Name: signal peptide peptidase 2Cprovided by MGI
Primary source: MGI:MGI:3045264
See related: Ensembl:ENSMUSG00000049506 AllianceGenome:MGI:3045264
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IMP5; 4933407P14Rik
Summary: Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in membrane protein proteolysis. Predicted to act upstream of or within proteolysis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi-associated vesicle membrane and lysosomal membrane. Predicted to be integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. Orthologous to human SPPL2C (signal peptide peptidase like 2C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 311.2) See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 67.79 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (104077153..104081992)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (104186327..104191166)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest involvement of SPPL2c in acrosome formation during spermatogenesis.
Title: Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins.
the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA2)-regulating protein phospholamban (PLN) is identified as a physiological SPPL2c substrate.
Title: The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aspartic endopeptidase activity, intramembrane cleaving	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic endopeptidase activity, intramembrane cleaving	IDA Inferred from Direct Assay more info	PubMed
enables aspartic-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acrosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane protein intracellular domain proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane protein proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi-associated vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic side of endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in lumenal side of endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lumenal side of endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: signal peptide peptidase-like 2C

Names: IMP-5; SPP-like 2C; intramembrane protease 5; ortholog of human intramembrane protease 5 IMP5; protein SPP-like 2C; protein SPPL2c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082535.1 → NP_001076004.1 signal peptide peptidase-like 2C isoform b precursor

See identical proteins and their annotated locations for NP_001076004.1

Status: VALIDATED

Source sequence(s)

AK077122, BC090973, BC100418, CF197856

Consensus CDS

CCDS36351.1

UniProtKB/Swiss-Prot

A2A6C4

Related

ENSMUSP00000091453.6, ENSMUST00000059448.8

Conserved Domains (2) summary

cl01342
Location:254 → 538

Peptidase_A22B; Signal peptide peptidase

cl10459
Location:44 → 181

Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
NM_199019.2 → NP_950184.2 signal peptide peptidase-like 2C isoform a precursor

See identical proteins and their annotated locations for NP_950184.2

Status: VALIDATED

Source sequence(s)

AK077122, AV279514, BC090973

Consensus CDS

CCDS36352.1

UniProtKB/Swiss-Prot

A2A6C4, Q497R4, Q8BHP0

Related

ENSMUSP00000102613.2, ENSMUST00000107000.2

Conserved Domains (2) summary

cl01342
Location:254 → 538

Peptidase_A22B; Signal peptide peptidase

cl10459
Location:44 → 181

Peptidases_S8_S53; Peptidase domain in the S8 and S53 families