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Rsad1 radical S-adenosyl methionine domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 237926, updated on 11-Apr-2024

Summary

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Official Symbol
Rsad1provided by MGI
Official Full Name
radical S-adenosyl methionine domain containing 1provided by MGI
Primary source
MGI:MGI:3039628
See related
Ensembl:ENSMUSG00000039096 AllianceGenome:MGI:3039628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B430319G23
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity and heme binding activity. Predicted to be involved in porphyrin-containing compound biosynthetic process. Located in mitochondrion. Is expressed in cartilage; central nervous system; liver; and spleen. Orthologous to human RSAD1 (radical S-adenosyl methionine domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 8.0), adrenal adult (RPKM 7.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 58.9 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94430624..94447690, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (94539798..94556862, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene epsin 3 Neighboring gene predicted gene, 51873 Neighboring gene MYCBP associated protein Neighboring gene predicted gene, 35650 Neighboring gene acyl-CoA synthetase family member 2 Neighboring gene STARR-seq mESC enhancer starr_30470 Neighboring gene chondroadherin Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:94452878-94453079 Neighboring gene STARR-seq mESC enhancer starr_30472 Neighboring gene STARR-positive B cell enhancer mm9_chr11:94490883-94491183 Neighboring gene leucine rich repeat containing 59 Neighboring gene essential meiotic structure-specific endonuclease 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis. Khan RS, et al. Sci Rep, 2019 Aug 12. PMID 31406150, Free PMC Article
  2. T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system. Mohan RA, et al. Proc Natl Acad Sci U S A, 2020 Aug 4. PMID 32675240, Free PMC Article
  3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables coproporphyrinogen oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in porphyrin-containing compound biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
radical S-adenosyl methionine domain-containing protein 1, mitochondrial
Names
oxygen-independent coproporphyrinogen-III oxidase-like protein RSAD1
putative heme chaperone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013381.2 → NP_001013399.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001013399.1

    Status: VALIDATED

    Source sequence(s)
    AK148401, AW060343, BB645699, BC056485
    Consensus CDS
    CCDS25258.1
    UniProtKB/Swiss-Prot
    B2RTE1, Q5SUV1, Q6PHM8
    Related
    ENSMUSP00000037361.4, ENSMUST00000040487.4
    Conserved Domains (1) summary
    PRK09057
    Location:41 → 373
    PRK09057; coproporphyrinogen III oxidase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    94430624..94447690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248992.4 → XP_011247294.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011247294.1

    UniProtKB/Swiss-Prot
    B2RTE1, Q5SUV1, Q6PHM8
    Conserved Domains (1) summary
    PRK09057
    Location:41 → 373
    PRK09057; coproporphyrinogen III oxidase; Provisional

  2. XM_011248993.4 → XP_011247295.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011247295.1

    Conserved Domains (1) summary
    PRK09057
    Location:5 → 177
    PRK09057; coproporphyrinogen III oxidase; Provisional

  3. XM_036156664.1 → XP_036012557.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

    Conserved Domains (1) summary
    PRK09057
    Location:5 → 177
    PRK09057; coproporphyrinogen III oxidase; Provisional

  4. XM_006533242.5 → XP_006533305.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006533305.1

    Conserved Domains (1) summary
    PRK09057
    Location:5 → 177
    PRK09057; coproporphyrinogen III oxidase; Provisional

  5. XM_011248994.4 → XP_011247296.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011247296.1

    Conserved Domains (1) summary
    PRK09057
    Location:5 → 177
    PRK09057; coproporphyrinogen III oxidase; Provisional

  6. XM_030245973.2 → XP_030101833.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

    Conserved Domains (1) summary
    PRK09057
    Location:5 → 177
    PRK09057; coproporphyrinogen III oxidase; Provisional

  7. XM_030245972.2 → XP_030101832.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

    Conserved Domains (1) summary
    PRK09057
    Location:5 → 177
    PRK09057; coproporphyrinogen III oxidase; Provisional

  8. XM_006533243.4 → XP_006533306.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006533306.1

    Related
    ENSMUST00000132274.8
    Conserved Domains (1) summary
    PRK09057
    Location:5 → 177
    PRK09057; coproporphyrinogen III oxidase; Provisional

  9. XM_006533244.5 → XP_006533307.1  radical S-adenosyl methionine domain-containing protein 1, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006533307.1

    Conserved Domains (1) summary
    PRK09057
    Location:5 → 177
    PRK09057; coproporphyrinogen III oxidase; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SUV1.1 GenPept UniProtKB/Swiss-Prot:Q5SUV1

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