Coro1c coronin, actin binding protein 1C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Coro1cprovided by MGI
Official Full Name: coronin, actin binding protein 1Cprovided by MGI
Primary source: MGI:MGI:1345964
See related: Ensembl:ENSMUSG00000004530 AllianceGenome:MGI:1345964
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CRN2
Summary: Enables small GTPase binding activity. Involved in several processes, including activation of GTPase activity; regulation of fibroblast migration; and regulation of ruffle assembly. Located in cytoskeleton. Part of flotillin complex. Is expressed in several structures, including brain; dorsal root ganglion; genitourinary system; liver; and spleen. Orthologous to human CORO1C (coronin 1C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in large intestine adult (RPKM 69.2), colon adult (RPKM 57.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 55.64 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (113980500..114046767, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (113842439..113908706, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coro1B and Coro1C regulate lamellipodia dynamics and cell motility by tuning branched actin turnover.
Title: Coro1B and Coro1C regulate lamellipodia dynamics and cell motility by tuning branched actin turnover.
Coronin 1C inhibits melanoma metastasis through regulation of MT1-MMP-containing extracellular vesicle secretion.
Title: Coronin 1C inhibits melanoma metastasis through regulation of MT1-MMP-containing extracellular vesicle secretion.
The results imply that CRN2 represents a pro-invasive effector within the tumour cell microenvironment of glioblastoma multiforme.
Title: CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells.
Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein
Title: Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein Trafficking.
Coronin 1C displays highly co-operative binding to actin filaments. We highlight a novel mode of coronin regulation, which has implications for how coronins orchestrate cytoskeletal dynamics.
Title: Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin.
These results indicate that glucose recruits coronin 3 near the plasma membrane, and that it regulates the retrograde transport of the secretory membrane in pancreatic beta-cells.
Title: Glucose-induced translocation of coronin 3 regulates the retrograde transport of the secretory membrane in the pancreatic beta-cells.
Results indicate that interaction of GDP-Rab27a and coronin 3 is important in stimulus-endocytosis coupling, and that GTP- and GDP-Rab27a regulates insulin membrane recycling at the distinct stages.
Title: The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines.
Coronin 3 is abundantly expressed in the adult CNS. All murine brain areas express coronin 3 during embryogenesis and the first postnatal stages.
Title: Coronin 3 and its role in murine brain morphogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235265

NoName (e-PCR)
- UniSTS:235269

AW455561 (e-PCR)
- UniSTS:179230

AW548837 (e-PCR)
- UniSTS:179231

D5Mit25 (e-PCR), detects polymorphism
- UniSTS:130384

RH125329 (e-PCR)
- UniSTS:162151

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cortical patch assembly	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of GTPase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in activation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within corpus callosum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in endosome fission	ISO Inferred from Sequence Orthology more info
involved_in endosome membrane tubulation	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane fission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural crest cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of ruffle assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	TAS Traceable Author Statement more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
part_of flotillin complex	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: coronin-1C

Names: coronin 1c; coronin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011779.3 → NP_035909.2 coronin-1C

See identical proteins and their annotated locations for NP_035909.2

Status: PROVISIONAL

Source sequence(s)

AK082986

Consensus CDS

CCDS19555.1

UniProtKB/Swiss-Prot

Q499X7, Q8VCQ5, Q9WUM4

UniProtKB/TrEMBL

Q3TF74, Q5PPQ7

Related

ENSMUSP00000004646.7, ENSMUST00000004646.13

Conserved Domains (6) summary

PTZ00421
Location:8 → 471

PTZ00421; coronin; Provisional

pfam05873
Location:429 → 474

Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)

pfam08953
Location:6 → 63

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:343 → 385

WD40_4; Type of WD40 repeat

sd00039
Location:36 → 78

7WD40; WD40 repeat [structural motif]

cl02567
Location:75 → 300

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...