Slfn14 schlafen 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slfn14provided by MGI
Official Full Name: schlafen 14provided by MGI
Primary source: MGI:MGI:2684866
See related: Ensembl:ENSMUSG00000082101 AllianceGenome:MGI:2684866
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm20; Slfn14-ps
Summary: Enables endoribonuclease activity and ribosome binding activity. Involved in RNA phosphodiester bond hydrolysis, endonucleolytic; mRNA catabolic process; and rRNA catabolic process. Located in nucleus. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 20. Orthologous to human SLFN14 (schlafen family member 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 11.9), liver E14.5 (RPKM 10.8) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 50.3 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (83165936..83177552, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (83275110..83286726, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heterozygous mutation SLFN14 K208N in mice mediates species-specific differences in platelet and erythroid lineage commitment.
Title: Heterozygous mutation SLFN14 K208N in mice mediates species-specific differences in platelet and erythroid lineage commitment.
SLFN14 is a novel antiviral factor for both DNA and RNA viruses
Title: Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IDA Inferred from Direct Assay more info	PubMed
enables ribosome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in platelet maturation	ISO Inferred from Sequence Orthology more info
involved_in rRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in rRNA catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein SLFN14

Names: Schlafen family member 14, CAST_EiJ strain specific; Schlafen family member 14, WSB_EiJ strain specific; schlafen family member 14, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166028.1 → NP_001159500.1 protein SLFN14

Status: VALIDATED

Source sequence(s)

AL603711

Consensus CDS

CCDS70269.1

UniProtKB/Swiss-Prot

V9GXG1

UniProtKB/TrEMBL

A0A1G5SK34, A0A1G5SK54

Related

ENSMUSP00000139132.2, ENSMUST00000163961.3

Conserved Domains (2) summary

PHA02782
Location:9 → 334

PHA02782; hypothetical protein; Provisional

pfam04326
Location:195 → 305

AlbA_2; Putative DNA-binding domain