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Slfn9 schlafen 9 [ Mus musculus (house mouse) ]

Gene ID: 237886, updated on 11-Apr-2024

Summary

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Official Symbol
Slfn9provided by MGI
Official Full Name
schlafen 9provided by MGI
Primary source
MGI:MGI:2445121
See related
Ensembl:ENSMUSG00000069793 AllianceGenome:MGI:2445121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9830137M10Rik
Summary
Predicted to enable endoribonuclease activity; tRNA binding activity; and zinc ion binding activity. Predicted to be involved in defense response to virus; rRNA catabolic process; and tRNA catabolic process. Located in nucleus. Orthologous to human SLFN11 (schlafen family member 11) and SLFN13 (schlafen family member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 2.0), CNS E11.5 (RPKM 1.6) and 20 other tissues See more
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Genomic context

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See Slfn9 in Genome Data Viewer
Location:
11 C; 11 50.3 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82865142..82883041, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82974316..82991830, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene schlafen 5, opposite strand Neighboring gene schlafen 5 Neighboring gene SET domain-containing protein 8 pseudogene Neighboring gene microRNA 7679 Neighboring gene schlafen 8 Neighboring gene 60S ribosomal protein L12 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Subcellular localization of the Schlafen protein family. Neumann B, et al. Biochem Biophys Res Commun, 2008 May 23. PMID 18355440
  2. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence. Bustos O, et al. Gene, 2009 Nov 1. PMID 19619625, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.
    Title: Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA decay ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
schlafen family member 9
Names
Schlafen family member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172796.2 → NP_766384.2  schlafen family member 9

    See identical proteins and their annotated locations for NP_766384.2

    Status: VALIDATED

    Source sequence(s)
    AK036579, AY261800
    Consensus CDS
    CCDS25154.1
    UniProtKB/Swiss-Prot
    A0A0A0MQG6, B1ARD6, Q7TME8, Q7TME9, Q80VG8, Q8C7F7, Q8CB82
    UniProtKB/TrEMBL
    A0A1G5SL47
    Related
    ENSMUSP00000044435.6, ENSMUST00000038211.13
    Conserved Domains (3) summary
    PHA02782
    Location:45 → 346
    PHA02782; hypothetical protein; Provisional
    pfam13538
    Location:852 → 895
    UvrD_C_2; UvrD-like helicase C-terminal domain
    pfam09848
    Location:595 → 765
    DUF2075; Uncharacterized conserved protein (DUF2075)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    82865142..82883041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533235.5 → XP_006533298.1  schlafen family member 9 isoform X1

    See identical proteins and their annotated locations for XP_006533298.1

    UniProtKB/Swiss-Prot
    A0A0A0MQG6, B1ARD6, Q7TME8, Q7TME9, Q80VG8, Q8C7F7, Q8CB82
    UniProtKB/TrEMBL
    A0A1G5SL47
    Conserved Domains (3) summary
    PHA02782
    Location:45 → 346
    PHA02782; hypothetical protein; Provisional
    pfam13538
    Location:852 → 895
    UvrD_C_2; UvrD-like helicase C-terminal domain
    pfam09848
    Location:595 → 765
    DUF2075; Uncharacterized conserved protein (DUF2075)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1ARD6.1 GenPept UniProtKB/Swiss-Prot:B1ARD6

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