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Ssh2 slingshot protein phosphatase 2 [ Mus musculus (house mouse) ]

Gene ID: 237860, updated on 11-Apr-2024

Summary

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Official Symbol
Ssh2provided by MGI
Official Full Name
slingshot protein phosphatase 2provided by MGI
Primary source
MGI:MGI:2679255
See related
Ensembl:ENSMUSG00000037926 AllianceGenome:MGI:2679255
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SSH-2; SSH-2L; mSSH-2L
Summary
Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Predicted to be involved in several processes, including negative regulation of actin filament polymerization; positive regulation of cell migration; and protein dephosphorylation. Predicted to be located in cell junction and cytoskeleton. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; hemolymphoid system; liver; nervous system; and neural retinal epithelium. Orthologous to human SSH2 (slingshot protein phosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 9.0), heart adult (RPKM 4.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 46.36 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77107020..77351046)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77216157..77460220)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 5 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30052 Neighboring gene upstream transcription factor 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8428 Neighboring gene STARR-positive B cell enhancer ABC_E7022 Neighboring gene STARR-positive B cell enhancer ABC_E3978 Neighboring gene predicted gene, 24989 Neighboring gene heat shock protein 1, alpha pseudogene Neighboring gene STARR-seq mESC enhancer starr_30053 Neighboring gene VISTA enhancer mm146 Neighboring gene 60S ribosomal protein L35-like Neighboring gene STARR-positive B cell enhancer ABC_E5248 Neighboring gene STARR-seq mESC enhancer starr_30055 Neighboring gene microRNA mir-12181 Neighboring gene ankyrin repeat domain 13b Neighboring gene coronin 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. Tang W, et al. Dev Cell, 2011 Dec 13. PMID 22172670, Free PMC Article
  2. Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for mouse development. Kousaka K, et al. Genesis, 2008 May. PMID 18442045
  3. Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. Ohta Y, et al. Genes Cells, 2003 Oct. PMID 14531860
  4. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A PLCbeta/PI3Kgamma-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis.
    Title: A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase Slingshot homolog 2
Names
SSH-like protein 2
slingshot 2L
slingshot homolog 2
slingshot-like 2
NP_001278119.1
NP_808378.2
XP_006533290.1
XP_006533291.1
XP_006533292.1
XP_030101826.1
XP_036012553.1
XP_036012554.1
XP_036012555.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291190.1 → NP_001278119.1  protein phosphatase Slingshot homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001278119.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, uses an alternate start codon, and uses an alternate splice site in the central coding region, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB099288, AK158449, AL607072
    Consensus CDS
    CCDS70248.1
    UniProtKB/TrEMBL
    A0A0R4J2A0
    Related
    ENSMUSP00000137933.2, ENSMUST00000181283.3
    Conserved Domains (3) summary
    cd11652
    Location:10 → 242
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:314 → 449
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:257 → 308
    DEK_C; DEK C terminal domain

  2. NM_177710.4 → NP_808378.2  protein phosphatase Slingshot homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_808378.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AB099288, AL607072, BC141393
    Consensus CDS
    CCDS25076.1
    UniProtKB/Swiss-Prot
    B9EJ94, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q5SW75, Q69ZC3, Q76I78
    Related
    ENSMUSP00000042625.6, ENSMUST00000037912.12
    Conserved Domains (3) summary
    cd11652
    Location:3 → 236
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:308 → 443
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:251 → 302
    DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    77107020..77351046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533227.5 → XP_006533290.1  protein phosphatase Slingshot homolog 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5SW75
    Conserved Domains (3) summary
    cd11652
    Location:40 → 263
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd14569
    Location:332 → 475
    DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
    pfam08766
    Location:277 → 329
    DEK_C; DEK C terminal domain

  2. XM_036156662.1 → XP_036012555.1  protein phosphatase Slingshot homolog 2 isoform X7

    Conserved Domains (3) summary
    cd11652
    Location:3 → 191
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd14569
    Location:260 → 403
    DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
    pfam08766
    Location:205 → 257
    DEK_C; DEK C terminal domain

  3. XM_030245966.2 → XP_030101826.1  protein phosphatase Slingshot homolog 2 isoform X4

    Conserved Domains (3) summary
    cd11652
    Location:3 → 235
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd14569
    Location:304 → 447
    DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
    pfam08766
    Location:249 → 301
    DEK_C; DEK C terminal domain

  4. XM_006533228.5 → XP_006533291.1  protein phosphatase Slingshot homolog 2 isoform X2

    Conserved Domains (3) summary
    cd11652
    Location:40 → 262
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd14569
    Location:331 → 474
    DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
    pfam08766
    Location:276 → 328
    DEK_C; DEK C terminal domain

  5. XM_036156660.1 → XP_036012553.1  protein phosphatase Slingshot homolog 2 isoform X5

    Conserved Domains (3) summary
    cd11652
    Location:40 → 218
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd14569
    Location:287 → 430
    DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
    pfam08766
    Location:232 → 284
    DEK_C; DEK C terminal domain

  6. XM_006533229.5 → XP_006533292.1  protein phosphatase Slingshot homolog 2 isoform X3

    See identical proteins and their annotated locations for XP_006533292.1

    UniProtKB/Swiss-Prot
    Q5SW75
    Conserved Domains (3) summary
    cd11652
    Location:10 → 243
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd14569
    Location:312 → 455
    DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
    pfam08766
    Location:257 → 309
    DEK_C; DEK C terminal domain

  7. XM_036156661.1 → XP_036012554.1  protein phosphatase Slingshot homolog 2 isoform X6

    Conserved Domains (3) summary
    cd11652
    Location:10 → 198
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd14569
    Location:267 → 410
    DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
    pfam08766
    Location:212 → 264
    DEK_C; DEK C terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SW75.2 GenPept UniProtKB/Swiss-Prot:Q5SW75

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