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Rtn4rl1 reticulon 4 receptor-like 1 [ Mus musculus (house mouse) ]

Gene ID: 237847, updated on 21-Apr-2024

Summary

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Official Symbol
Rtn4rl1provided by MGI
Official Full Name
reticulon 4 receptor-like 1provided by MGI
Primary source
MGI:MGI:2661375
See related
Ensembl:ENSMUSG00000045287 AllianceGenome:MGI:2661375
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ngr3; Ngrh2; Ngrl2
Summary
Enables chondroitin sulfate binding activity and heparin binding activity. Involved in corpus callosum development and negative regulation of axon regeneration. Predicted to be located in external side of plasma membrane and membrane raft. Predicted to be anchored component of plasma membrane. Is expressed in brain; ganglia; heart; peripheral nervous system; and spinal cord. Orthologous to human RTN4RL1 (reticulon 4 receptor like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 25.5), bladder adult (RPKM 10.8) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 45.76 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75084819..75158595)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75193993..75267769)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700016P03 gene Neighboring gene STARR-positive B cell enhancer ABC_E7016 Neighboring gene microRNA 132 Neighboring gene candidate tumor suppressor in ovarian cancer 2 Neighboring gene STARR-seq mESC enhancer starr_29983 Neighboring gene diphthamide biosynthesis 1 Neighboring gene STARR-seq mESC enhancer starr_29985 Neighboring gene STARR-seq mESC enhancer starr_29986 Neighboring gene predicted gene, 35169 Neighboring gene predicted gene, 35117 Neighboring gene replication protein A1 Neighboring gene STARR-positive B cell enhancer ABC_E9826 Neighboring gene STARR-positive B cell enhancer ABC_E3972 Neighboring gene STARR-seq mESC enhancer starr_29990 Neighboring gene STARR-seq mESC enhancer starr_29991 Neighboring gene SET and MYND domain containing 4 Neighboring gene serine (or cysteine) peptidase inhibitor, clade F, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. B-cells expressing NgR1 and NgR3 are localized to EAE-induced inflammatory infiltrates and are stimulated by BAFF. Bakhuraysah MM, et al. Sci Rep, 2021 Feb 3. PMID 33536561, Free PMC Article
  2. Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels. Zhao Y, et al. Neuron, 2017 Oct 11. PMID 29024660, Free PMC Article
  3. The nogo receptor family restricts synapse number in the developing hippocampus. Wills ZP, et al. Neuron, 2012 Feb 9. PMID 22325200, Free PMC Article
  4. Agenesis of the corpus callosum in Nogo receptor deficient mice. Yoo SW, et al. J Comp Neurol, 2017 Feb 1. PMID 27339102, Free PMC Article
  5. Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. Pignot V, et al. J Neurochem, 2003 May. PMID 12694398

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Roundabout binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chondroitin sulfate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in corpus callosum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
reticulon-4 receptor-like 1
Names
nogo receptor-like 2
nogo-66 receptor homolog 2
nogo-66 receptor-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177708.5 → NP_808376.1  reticulon-4 receptor-like 1 precursor

    See identical proteins and their annotated locations for NP_808376.1

    Status: PROVISIONAL

    Source sequence(s)
    AK140456
    Consensus CDS
    CCDS25043.1
    UniProtKB/Swiss-Prot
    Q8K0S5
    Related
    ENSMUSP00000099572.4, ENSMUST00000102514.4
    Conserved Domains (4) summary
    cd00116
    Location:102 → 255
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:150 → 188
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:174 → 233
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75084819..75158595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533225.2 → XP_006533288.1  reticulon-4 receptor-like 1 isoform X1

    Conserved Domains (3) summary
    COG4886
    Location:108 → 308
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:131 → 154
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:227 → 286
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0S5.1 GenPept UniProtKB/Swiss-Prot:Q8K0S5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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