U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

POTEH POTE ankyrin domain family member H [ Homo sapiens (human) ]

Gene ID: 23784, updated on 3-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
POTEHprovided by HGNC
Official Full Name
POTE ankyrin domain family member Hprovided by HGNC
Primary source
HGNC:HGNC:133
See related
Ensembl:ENSG00000198062 MIM:608913; AllianceGenome:HGNC:133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A26C3; ACTBL1; POTE22; CT104.7
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward prostate (RPKM 11.9) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See POTEH in Genome Data Viewer
Location:
22q11.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (15690026..15721631)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (16263953..16295528)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (16256332..16287937, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene NEK2 pseudogene 2 Neighboring gene neurofibromin 1 pseudogene 6 Neighboring gene mediator complex subunit 15 pseudogene 7 Neighboring gene POTEH antisense RNA 1 Neighboring gene RNA, U6 small nuclear 816, pseudogene Neighboring gene prostate enriched lncRNA Neighboring gene GRAM domain containing 4 pseudogene 2 Neighboring gene OCT4 hESC enhancer GRCh37_chr22:16212624-16213125 Neighboring gene double homeobox A pseudogene 8 Neighboring gene BMS1 pseudogene 22

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. POTEH hypomethylation, a new epigenetic biomarker for glioma prognosis. Liu X, et al. Brain Res, 2011 May 19. PMID 21439273
  2. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. Bera TK, et al. Gene, 2004 Aug 4. PMID 15276201
  3. POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. Bera TK, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12475935, Free PMC Article
  4. The DNA sequence of human chromosome 22. Dunham I, et al. Nature, 1999 Dec 2. PMID 10591208
  5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

General protein information

Go to the top of the page Help
Preferred Names
POTE ankyrin domain family member H
Names
ANKRD26-like family C member 3
actin, beta-like 1
cancer/testis antigen family 104, member 7
prostate, ovary, testis-expressed protein on chromosome 22
protein expressed in prostate, ovary, testis, and placenta 22
protein expressed in prostate, ovary, testis, and placenta POTE14 like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136213.1 → NP_001129685.1  POTE ankyrin domain family member H

    See identical proteins and their annotated locations for NP_001129685.1

    Status: VALIDATED

    Source sequence(s)
    AP000529, CR545463
    Consensus CDS
    CCDS74808.1
    UniProtKB/Swiss-Prot
    A2CEK4, A6NCI1, A9Z1W0, Q6S545
    UniProtKB/TrEMBL
    A0A087X187
    Related
    ENSP00000340610.6, ENST00000343518.11
    Conserved Domains (4) summary
    cd00204
    Location:204 → 329
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:214 → 306
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:180 → 230
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:275 → 306
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    15690026..15721631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    16263953..16295528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001004053.2: Suppressed sequence

    Description
    NM_001004053.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6S545.3 GenPept UniProtKB/Swiss-Prot:Q6S545

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous