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Dnah9 dynein, axonemal, heavy chain 9 [ Mus musculus (house mouse) ]

Gene ID: 237806, updated on 11-Apr-2024

Summary

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Official Symbol
Dnah9provided by MGI
Official Full Name
dynein, axonemal, heavy chain 9provided by MGI
Primary source
MGI:MGI:1289279
See related
Ensembl:ENSMUSG00000056752 AllianceGenome:MGI:1289279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dnahc9; mKIAA0357; 9030022M04; A230091C01; C230051G16; D11Ertd686e
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Acts upstream of or within cerebrospinal fluid circulation and mucociliary clearance. Located in 9+2 motile cilium and distal portion of axoneme. Part of outer dynein arm. Is expressed in central nervous system and testis. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 40. Orthologous to human DNAH9 (dynein axonemal heavy chain 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Dnah9 in Genome Data Viewer
Location:
11 B3; 11 40.53 cM
Exon count:
69
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (65722150..66059379, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (65831324..66168581, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 4 Neighboring gene predicted gene, 53682 Neighboring gene zinc finger with KRAB and SCAN domains 6 Neighboring gene STARR-seq mESC enhancer starr_29773 Neighboring gene STARR-seq mESC enhancer starr_29774 Neighboring gene predicted gene, 40027 Neighboring gene predicted gene 12296 Neighboring gene shisa family member 6 Neighboring gene predicted gene, 45945 Neighboring gene STARR-seq mESC enhancer starr_29776 Neighboring gene STARR-seq mESC enhancer starr_29777 Neighboring gene predicted gene, 40028

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening. Zheng R, et al. Cell Death Dis, 2022 Jun 21. PMID 35729109, Free PMC Article
  2. Biallelic DNAH9 mutations are identified in Chinese patients with defective left-right patterning and cilia-related complex congenital heart disease. Chen W, et al. Hum Genet, 2022 Aug. PMID 35050399
  3. The establishment of rotational polarity in the airway and ependymal cilia: analysis with a novel cilium motility mutant mouse. Matsuo M, et al. Am J Physiol Lung Cell Mol Physiol, 2013 Jun 1. PMID 23525783
  4. Primary ciliary dyskinesia: genes, candidate genes and chromosomal regions. Geremek M, et al. J Appl Genet, 2004. PMID 15306728
  5. CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components. Ide T, et al. PLoS Genet, 2020 Dec. PMID 33347437, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biallelic DNAH9 mutations are identified in Chinese patients with defective left-right patterning and cilia-related complex congenital heart disease.
    Title: Biallelic DNAH9 mutations are identified in Chinese patients with defective left-right patterning and cilia-related complex congenital heart disease.
  2. Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening.
    Title: Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • KIAA0357

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cerebrospinal fluid circulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium movement ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mucociliary clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in 9+2 motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in 9+2 motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in 9+2 motile cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in distal portion of axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in distal portion of axoneme ISO
Inferred from Sequence Orthology
more info
  
part_of dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
part_of outer dynein arm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dynein axonemal heavy chain 9
Names
dynein, axonemal, heavy polypeptide 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099633.2 → NP_001093103.1  dynein axonemal heavy chain 9

    See identical proteins and their annotated locations for NP_001093103.1

    Status: VALIDATED

    Source sequence(s)
    AL596025, AL596187
    Consensus CDS
    CCDS36182.1
    UniProtKB/TrEMBL
    B1AR51
    Related
    ENSMUSP00000079494.4, ENSMUST00000080665.10
    Conserved Domains (6) summary
    pfam03028
    Location:3785 → 4474
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:210 → 787
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1293 → 1697
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:3065 → 3408
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:3436 → 3648
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:2437 → 2708
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    65722150..66059379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533213.5 → XP_006533276.1  dynein axonemal heavy chain 9 isoform X3

    Conserved Domains (7) summary
    COG5245
    Location:1363 → 3994
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:2911 → 3254
    MT; Microtubule-binding stalk of dynein motor
    pfam08385
    Location:212 → 633
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1136 → 1542
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1676 → 2002
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2639 → 2898
    AAA_8; P-loop containing dynein motor region D4
    pfam18199
    Location:4033 → 4328
    Dynein_C; Dynein heavy chain C-terminal domain

  2. XM_017314522.3 → XP_017170011.1  dynein axonemal heavy chain 9 isoform X5

    Conserved Domains (13) summary
    pfam12777
    Location:2859 → 3187
    MT; Microtubule-binding stalk of dynein motor
    pfam03028
    Location:3683 → 3799
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:212 → 787
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1290 → 1696
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1830 → 2156
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12775
    Location:2437 → 2616
    AAA_7; P-loop containing dynein motor region D3
    pfam12781
    Location:3215 → 3428
    AAA_9; ATP-binding dynein motor region D5
    pfam17852
    Location:2315 → 2430
    Dynein_AAA_lid; Dynein heavy chain AAA lid domain
    pfam17857
    Location:2649 → 2748
    AAA_lid_1; AAA+ lid domain
    pfam18198
    Location:3801 → 3960
    AAA_lid_11; Dynein heavy chain AAA lid domain
    pfam18199
    Location:3966 → 4261
    Dynein_C; Dynein heavy chain C-terminal domain
    cl38936
    Location:2144 → 2279
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl38985
    Location:2793 → 2864
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_006533212.5 → XP_006533275.1  dynein axonemal heavy chain 9 isoform X2

    Conserved Domains (7) summary
    COG5245
    Location:1517 → 4070
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:2985 → 3330
    MT; Microtubule-binding stalk of dynein motor
    pfam08385
    Location:212 → 787
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1290 → 1696
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1830 → 2156
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12781
    Location:3358 → 3571
    AAA_9; ATP-binding dynein motor region D5
    pfam18199
    Location:4109 → 4404
    Dynein_C; Dynein heavy chain C-terminal domain

  4. XM_017314521.3 → XP_017170010.1  dynein axonemal heavy chain 9 isoform X1

    Conserved Domains (7) summary
    COG5245
    Location:1517 → 4107
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:3065 → 3408
    MT; Microtubule-binding stalk of dynein motor
    pfam08385
    Location:212 → 787
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1290 → 1696
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1830 → 2156
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2793 → 3052
    AAA_8; P-loop containing dynein motor region D4
    pfam18199
    Location:4146 → 4441
    Dynein_C; Dynein heavy chain C-terminal domain

  5. XM_006533214.3 → XP_006533277.1  dynein axonemal heavy chain 9 isoform X4

    Conserved Domains (7) summary
    COG5245
    Location:1319 → 3950
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:2867 → 3210
    MT; Microtubule-binding stalk of dynein motor
    pfam08385
    Location:14 → 589
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1092 → 1498
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1632 → 1958
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2595 → 2854
    AAA_8; P-loop containing dynein motor region D4
    pfam18199
    Location:3989 → 4284
    Dynein_C; Dynein heavy chain C-terminal domain

  6. XM_036156656.1 → XP_036012549.1  dynein axonemal heavy chain 9 isoform X7

    Conserved Domains (5) summary
    COG5245
    Location:437 → 3068
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:1985 → 2328
    MT; Microtubule-binding stalk of dynein motor
    pfam08393
    Location:210 → 616
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:750 → 1076
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:3107 → 3402
    Dynein_C; Dynein heavy chain C-terminal domain

  7. XM_036156657.1 → XP_036012550.1  dynein axonemal heavy chain 9 isoform X7

    Conserved Domains (5) summary
    COG5245
    Location:437 → 3068
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:1985 → 2328
    MT; Microtubule-binding stalk of dynein motor
    pfam08393
    Location:210 → 616
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:750 → 1076
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:3107 → 3402
    Dynein_C; Dynein heavy chain C-terminal domain

  8. XM_017314523.3 → XP_017170012.1  dynein axonemal heavy chain 9 isoform X6

    Conserved Domains (6) summary
    COG5245
    Location:1517 → 4095
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12777
    Location:3065 → 3408
    MT; Microtubule-binding stalk of dynein motor
    pfam08385
    Location:212 → 787
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1290 → 1696
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1830 → 2156
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2793 → 3052
    AAA_8; P-loop containing dynein motor region D4

  9. XM_017314525.3 → XP_017170014.1  dynein axonemal heavy chain 9 isoform X8

    Conserved Domains (5) summary
    COG5245
    Location:1517 → 2899
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:212 → 787
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1290 → 1696
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1830 → 2156
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12775
    Location:2437 → 2616
    AAA_7; P-loop containing dynein motor region D3

  10. XM_006533218.5 → XP_006533281.1  dynein axonemal heavy chain 9 isoform X9

    Conserved Domains (4) summary
    pfam08385
    Location:212 → 787
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1290 → 1696
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1830 → 2156
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    cl38936
    Location:2144 → 2279
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_004936949.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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