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BRD1 bromodomain containing 1 [ Homo sapiens (human) ]

Gene ID: 23774, updated on 3-Apr-2024

Summary

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Official Symbol
BRD1provided by HGNC
Official Full Name
bromodomain containing 1provided by HGNC
Primary source
HGNC:HGNC:1102
See related
Ensembl:ENSG00000100425 MIM:604589; AllianceGenome:HGNC:1102
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRL; BRPF1; BRPF2
Summary
This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]
Expression
Broad expression in testis (RPKM 11.6), bone marrow (RPKM 4.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
22q13.33
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (49773278..49827873, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50277574..50332170, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50166926..50221521, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50156966-50157749 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50157750-50158532 Neighboring gene ribosomal protein L5 pseudogene 35 Neighboring gene Sharpr-MPRA regulatory region 11654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50199181-50199681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50209067-50209610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50209611-50210153 Neighboring gene suppressor of cytokine signaling 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50218197-50218776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13923 Neighboring gene uncharacterized LOC105377205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13924 Neighboring gene basic proline-rich protein-like Neighboring gene sterile alpha motif domain-containing protein 1-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13927 Neighboring gene uncharacterized LOC124905147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50250325-50250985 Neighboring gene zinc finger BED-type containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation. Paternoster V, et al. Transl Psychiatry, 2022 Aug 8. PMID 35941107, Free PMC Article
  2. Expression Characteristics and Clinical Correlations of BRD1 in Colorectal Cancer Samples. Li Z, et al. Technol Cancer Res Treat, 2021 Jan-Dec. PMID 34482774, Free PMC Article
  3. Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains. Zhang M, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Mar. PMID 33556623
  4. Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis. Klein K, et al. Sci Rep, 2018 Jul 24. PMID 30042400, Free PMC Article
  5. DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele. Dyrvig M, et al. PLoS One, 2017. PMID 28095495, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation.
    Title: The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation.
  2. Expression Characteristics and Clinical Correlations of BRD1 in Colorectal Cancer Samples.
    Title: Expression Characteristics and Clinical Correlations of BRD1 in Colorectal Cancer Samples.
  3. HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.
    Title: HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.
  4. Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.
    Title: Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.
  5. our data point to a cell type- and a stimulus-specific function of BRD1. Inhibiting BRD1 could have potential beneficial effects in rheumatoid arthritis via decreasing the proliferation of synovial fibroblasts. Anti-inflammatory effects were limited and only observed in monocyte-derived macrophages
    Title: Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis.
  6. Results show that interaction of sulfatide with BRD1 induced acetylation and promoted integrin alpha V gene transcription in hepatocellular carcinoma cells.
    Title: BRD1-Mediated Acetylation Promotes Integrin αV Gene Expression Via Interaction with Sulfatide.
  7. There was no association between SNPs in the BRD1 and ZBED4 genes and schizophrenia in the Chinese population.
    Title: No association of BRD1 and ZBED4 polymorphisms with schizophrenia in the Chinese Han population.
  8. TIMP-4, NT-proANP, NT-proBNP were strongest associated with PAF and AHRE. The discriminatory performance of CHADS2-VASc for PAF was increased by addition of selected biomarkers.
    Title: CHA2DS2-VASc score and blood biomarkers to identify patients with atrial high-rate episodes and paroxysmal atrial fibrillation.
  9. Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2 have been presented.
    Title: Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2.
  10. Reduced BRD1 expression is associated with Schizophrenia.
    Title: DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A comprehensive family-based replication study of schizophrenia genes.
EBI GWAS Catalog
Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster.
EBI GWAS Catalog
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of bromodomain containing 1 (BRD1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686F0325

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to histone H3K14 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to histone H4K12 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to histone H4K5 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to histone H4K8 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone reader activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in erythrocyte maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of developmental process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of hemopoiesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in response to immobilization stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MOZ/MORF histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MOZ/MORF histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
part_of histone H3-K14 acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bromodomain-containing protein 1
Names
BR140-like protein
bromodomain and PHD finger-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304808.3 → NP_001291737.1  bromodomain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001291737.1

    Status: REVIEWED

    Source sequence(s)
    AK292428, Z98885
    Consensus CDS
    CCDS77686.1
    UniProtKB/TrEMBL
    Q86X06
    Related
    ENSP00000385858.1, ENST00000404760.6
    Conserved Domains (5) summary
    cd05839
    Location:1058 → 1173
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:566 → 663
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:139 → 591
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15702
    Location:271 → 388
    ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
    pfam10513
    Location:47 → 196
    EPL1; Enhancer of polycomb-like

  2. NM_001304809.1 → NP_001291738.1  bromodomain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001291738.1

    Status: REVIEWED

    Source sequence(s)
    AA969405, AB209216, CR456408
    Consensus CDS
    CCDS14080.1
    UniProtKB/Swiss-Prot
    A6ZJA4, O95696
    UniProtKB/TrEMBL
    Q86X06
    Related
    ENSP00000384076.1, ENST00000404034.5
    Conserved Domains (5) summary
    cd05839
    Location:927 → 1042
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:566 → 663
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:139 → 591
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15702
    Location:271 → 388
    ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
    pfam10513
    Location:47 → 196
    EPL1; Enhancer of polycomb-like

  3. NM_001349940.2 → NP_001336869.1  bromodomain-containing protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    Z98885
    UniProtKB/TrEMBL
    Q86X06
    Conserved Domains (5) summary
    cd05839
    Location:976 → 1091
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:620 → 712
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15702
    Location:271 → 388
    ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
    pfam10513
    Location:47 → 196
    EPL1; Enhancer of polycomb-like
    cl26518
    Location:139 → 392
    EPL1; Enhancer of polycomb-like

  4. NM_001349941.2 → NP_001336870.1  bromodomain-containing protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    Z98885
    UniProtKB/TrEMBL
    Q86X06
    Conserved Domains (5) summary
    cd05839
    Location:1053 → 1168
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:566 → 658
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15702
    Location:271 → 388
    ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
    pfam10513
    Location:47 → 196
    EPL1; Enhancer of polycomb-like
    cl26518
    Location:139 → 606
    EPL1; Enhancer of polycomb-like

  5. NM_001349942.2 → NP_001336871.1  bromodomain-containing protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    Z98885
    UniProtKB/TrEMBL
    Q9Y4Q3
    Conserved Domains (2) summary
    cd05839
    Location:544 → 659
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:52 → 149
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

  6. NM_001394548.1 → NP_001381477.1  bromodomain-containing protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    Z98885
    UniProtKB/TrEMBL
    Q86X06
    Conserved Domains (5) summary
    cd05839
    Location:1056 → 1171
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:564 → 661
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:139 → 549
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15702
    Location:271 → 388
    ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
    pfam10513
    Location:47 → 196
    EPL1; Enhancer of polycomb-like

  7. NM_001394549.1 → NP_001381478.1  bromodomain-containing protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    Z98885
    UniProtKB/TrEMBL
    Q86X06
    Conserved Domains (4) summary
    cd05839
    Location:1051 → 1166
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:564 → 656
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:139 → 604
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15702
    Location:271 → 388
    ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins

  8. NM_001394550.1 → NP_001381479.1  bromodomain-containing protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    Z98885
    Conserved Domains (2) summary
    cd05839
    Location:413 → 528
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:52 → 149
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

  9. NM_001394551.1 → NP_001381480.1  bromodomain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    Z98885
    Consensus CDS
    CCDS14080.1
    UniProtKB/Swiss-Prot
    A6ZJA4, O95696
    UniProtKB/TrEMBL
    Q86X06
    Conserved Domains (5) summary
    cd05839
    Location:927 → 1042
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:566 → 663
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:139 → 591
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15702
    Location:271 → 388
    ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
    pfam10513
    Location:47 → 196
    EPL1; Enhancer of polycomb-like

  10. NM_001394552.1 → NP_001381481.1  bromodomain-containing protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    Z98885
    Consensus CDS
    CCDS14080.1
    UniProtKB/Swiss-Prot
    A6ZJA4, O95696
    UniProtKB/TrEMBL
    Q86X06
    Related
    ENSP00000216267.8, ENST00000216267.12
    Conserved Domains (5) summary
    cd05839
    Location:927 → 1042
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:566 → 663
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:139 → 591
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15702
    Location:271 → 388
    ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
    pfam10513
    Location:47 → 196
    EPL1; Enhancer of polycomb-like

RNA

  1. NR_146334.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    Z98885

  2. NR_146335.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    Z98885

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    49773278..49827873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441274.1 → XP_047297230.1  bromodomain-containing protein 1 isoform X5

  2. XM_017028722.3 → XP_016884211.2  bromodomain-containing protein 1 isoform X2

  3. XM_017028716.2 → XP_016884205.1  bromodomain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    Q86X06
    Conserved Domains (5) summary
    cd05839
    Location:1058 → 1173
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:566 → 663
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:139 → 591
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15702
    Location:271 → 388
    ePHD_BRPF2; Extended PHD finger found in bromodomain and PHD finger-containing protein 2 (BRPF2) and similar proteins
    pfam10513
    Location:47 → 196
    EPL1; Enhancer of polycomb-like

  4. XM_047441278.1 → XP_047297234.1  bromodomain-containing protein 1 isoform X9

  5. XM_047441281.1 → XP_047297237.1  bromodomain-containing protein 1 isoform X2

  6. XM_047441277.1 → XP_047297233.1  bromodomain-containing protein 1 isoform X8

  7. XM_017028718.2 → XP_016884207.1  bromodomain-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    Q86X06

  8. XM_047441276.1 → XP_047297232.1  bromodomain-containing protein 1 isoform X7

  9. XM_047441273.1 → XP_047297229.1  bromodomain-containing protein 1 isoform X4

  10. XM_047441271.1 → XP_047297227.1  bromodomain-containing protein 1 isoform X1

  11. XM_047441275.1 → XP_047297231.1  bromodomain-containing protein 1 isoform X6

  12. XM_047441272.1 → XP_047297228.1  bromodomain-containing protein 1 isoform X3

  13. XM_047441280.1 → XP_047297236.1  bromodomain-containing protein 1 isoform X12

  14. XM_047441283.1 → XP_047297239.1  bromodomain-containing protein 1 isoform X14

  15. XM_047441282.1 → XP_047297238.1  bromodomain-containing protein 1 isoform X13

  16. XM_047441279.1 → XP_047297235.1  bromodomain-containing protein 1 isoform X11

RNA

  1. XR_007067961.1 RNA Sequence

  2. XR_007067962.1 RNA Sequence

  3. XR_007067965.1 RNA Sequence

  4. XR_007067964.1 RNA Sequence

  5. XR_007067963.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    50277574..50332170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325421.1 → XP_054181396.1  bromodomain-containing protein 1 isoform X5

  2. XM_054325417.1 → XP_054181392.1  bromodomain-containing protein 1 isoform X2

  3. XM_054325420.1 → XP_054181395.1  bromodomain-containing protein 1 isoform X5

  4. XM_054325425.1 → XP_054181400.1  bromodomain-containing protein 1 isoform X9

  5. XM_054325429.1 → XP_054181404.1  bromodomain-containing protein 1 isoform X2

  6. XM_054325424.1 → XP_054181399.1  bromodomain-containing protein 1 isoform X8

  7. XM_054325426.1 → XP_054181401.1  bromodomain-containing protein 1 isoform X10

  8. XM_054325423.1 → XP_054181398.1  bromodomain-containing protein 1 isoform X7

  9. XM_054325419.1 → XP_054181394.1  bromodomain-containing protein 1 isoform X4

  10. XM_054325416.1 → XP_054181391.1  bromodomain-containing protein 1 isoform X1

  11. XM_054325422.1 → XP_054181397.1  bromodomain-containing protein 1 isoform X6

  12. XM_054325418.1 → XP_054181393.1  bromodomain-containing protein 1 isoform X3

  13. XM_054325428.1 → XP_054181403.1  bromodomain-containing protein 1 isoform X12

  14. XM_054325431.1 → XP_054181406.1  bromodomain-containing protein 1 isoform X14

  15. XM_054325430.1 → XP_054181405.1  bromodomain-containing protein 1 isoform X13

  16. XM_054325427.1 → XP_054181402.1  bromodomain-containing protein 1 isoform X11

RNA

  1. XR_008485373.1 RNA Sequence

  2. XR_008485374.1 RNA Sequence

  3. XR_008485377.1 RNA Sequence

  4. XR_008485376.1 RNA Sequence

  5. XR_008485375.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014577.1: Suppressed sequence

    Description
    NM_014577.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95696.1 GenPept UniProtKB/Swiss-Prot:O95696

Gene LinkOut

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