Lrrc10 leucine rich repeat containing 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrrc10provided by MGI
Official Full Name: leucine rich repeat containing 10provided by MGI
Primary source: MGI:MGI:2448063
See related: Ensembl:ENSMUSG00000060187 AllianceGenome:MGI:2448063
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hrlrrp; Serdin1; D330003I11Rik
Summary: Enables actin binding activity and alpha-actinin binding activity. Acts upstream of or within cardiac muscle cell development. Located in several cellular components, including cytoskeleton; mitochondrion; and sarcomere. Is expressed in heart and male reproductive gland or organ. Used to study dilated cardiomyopathy. Orthologous to human LRRC10 (leucine rich repeat containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 10 D2; 10 65.06 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (116881246..116882673)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (117045341..117046768)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LRRC10 is required to maintain cardiac performance in response to pressure overload and suggest that dysregulated expression or mutation of LRRC10
Title: LRRC10 is required to maintain cardiac function in response to pressure overload.
Data demonstrate that the transcription factors Nkx2-5 and GATA4 cooperatively regulate cardiac-specific expression of Lrrc10.
Title: Lrrc10 is a novel cardiac-specific target gene of Nkx2-5 and GATA4.
Lrrc10 is a novel dilated cardiomyopathy candidate gene and the Lrrc10-/- mouse model is a unique system to investigate pediatric cardiomyopathy.
Title: Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy.
GATA4 and MEF2C can both increase transcriptional activity of Lrrc10 promoter but that they do not work together in a synergistic fashion.
Title: Cloning and characterization of the cardiac-specific Lrrc10 promoter.
Lrrc10-null mice develop normally and exhibit no discernable phenotype
Title: Serdin1/Lrrc10 is dispensable for mouse development.
LRRC10 exhibits dynamic intracellular expression patterns in cardiomyocytes.
Title: Dynamic expression patterns of leucine-rich repeat containing protein 10 in the heart.
SERDIN1 is intimately integrated with the molecular pathways controlling cardiogenesis in vertebrates
Title: Expression and regulation of mouse SERDIN1, a highly conserved cardiac-specific leucine-rich repeat protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

UniSTS:471082 (e-PCR)
- UniSTS:471082

Lrrc10 (e-PCR), detects polymorphism
- UniSTS:471082

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables alpha-actinin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiac muscle cell development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in sarcomere	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: leucine-rich repeat-containing protein 10

Names: heart-restricted leucine-rich repeat protein; leucine-rich containing 10; leucine-rich repeat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146242.2 → NP_666354.1 leucine-rich repeat-containing protein 10

See identical proteins and their annotated locations for NP_666354.1

Status: VALIDATED

Source sequence(s)

AK142167, BC086911

Consensus CDS

CCDS24189.1

UniProtKB/Swiss-Prot

Q8BUL2, Q8K3W2

UniProtKB/TrEMBL

Q3UQT4

Related

ENSMUSP00000073502.5, ENSMUST00000073834.5

Conserved Domains (3) summary

cd00116
Location:92 → 200

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:32 → 53

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:52 → 110

LRR_8; Leucine rich repeat