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Ccdc38 coiled-coil domain containing 38 [ Mus musculus (house mouse) ]

Gene ID: 237465, updated on 11-Apr-2024

Summary

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Official Symbol
Ccdc38provided by MGI
Official Full Name
coiled-coil domain containing 38provided by MGI
Primary source
MGI:MGI:2444738
See related
Ensembl:ENSMUSG00000036168 AllianceGenome:MGI:2444738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933417K05Rik
Summary
Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in centrosome. Orthologous to human CCDC38 (coiled-coil domain containing 38). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 28.5), liver E14 (RPKM 4.2) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C2; 10 48.55 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93376451..93420189)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93540589..93584327)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene histidine ammonia lyase Neighboring gene STARR-positive B cell enhancer ABC_E8360 Neighboring gene STARR-seq mESC enhancer starr_27586 Neighboring gene amidohydrolase domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6903 Neighboring gene RIKEN cDNA 4933408J17 gene Neighboring gene STARR-positive B cell enhancer ABC_E6904 Neighboring gene STARR-positive B cell enhancer ABC_E9800 Neighboring gene small nuclear ribonucleoprotein polypeptide F Neighboring gene STARR-seq mESC enhancer starr_27587 Neighboring gene netrin 4 Neighboring gene ribosomal protein L29 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characteristics of the testes-specific gene, Ccdc38, in mice. Lin SR, et al. Mol Med Rep, 2016 Aug. PMID 27278724
  2. CCDC38 is required for sperm flagellum biogenesis and male fertility in mice. Zhang R, et al. Development, 2022 Jun 1. PMID 35587122
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CCDC38 is required for sperm flagellum biogenesis and male fertility in mice.
    Title: CCDC38 is required for sperm flagellum biogenesis and male fertility in mice.
  2. these results suggest that Ccdc38 is a testes-specific gene, which may be important for mouse spermatogenesis.
    Title: Identification and characteristics of the testes-specific gene, Ccdc38, in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-modified histone reader activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in acrosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of intraciliary anterograde transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of sperm flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cilium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in manchette IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm head IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
coiled-coil domain-containing protein 38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359749.1 → NP_001346678.1  coiled-coil domain-containing protein 38 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124585, AK029803, AK030205, AV280828
    Consensus CDS
    CCDS88074.1
    Related
    ENSMUSP00000150407.2, ENSMUST00000132214.8
    Conserved Domains (1) summary
    pfam13863
    Location:12 → 130
    DUF4200; Domain of unknown function (DUF4200)

  2. NM_175488.6 → NP_780697.2  coiled-coil domain-containing protein 38 isoform 1

    See identical proteins and their annotated locations for NP_780697.2

    Status: VALIDATED

    Source sequence(s)
    AC124585
    Consensus CDS
    CCDS24127.1
    UniProtKB/Swiss-Prot
    Q8CDD6, Q8CDE1, Q8CDN8
    Related
    ENSMUSP00000089860.6, ENSMUST00000092215.6
    Conserved Domains (1) summary
    pfam13863
    Location:112 → 230
    DUF4200; Domain of unknown function (DUF4200)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    93376451..93420189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513628.4 → XP_006513691.1  coiled-coil domain-containing protein 38 isoform X1

    Conserved Domains (1) summary
    pfam13863
    Location:112 → 230
    DUF4200; Domain of unknown function (DUF4200)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CDN8.1 GenPept UniProtKB/Swiss-Prot:Q8CDN8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Chemical Information
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