U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cdk17 cyclin dependent kinase 17 [ Mus musculus (house mouse) ]

Gene ID: 237459, updated on 25-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Cdk17provided by MGI
Official Full Name
cyclin dependent kinase 17provided by MGI
Primary source
MGI:MGI:97517
See related
Ensembl:ENSMUSG00000020015 AllianceGenome:MGI:97517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pctk2; 6430598J10Rik
Summary
Predicted to enable ATP binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; inner ear; and retina. Orthologous to human CDK17 (cyclin dependent kinase 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 15.4), cortex adult (RPKM 13.0) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10 C2; 10 47.89 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (92996492..93086956)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93160876..93251094)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40740 Neighboring gene predicted gene, 40741 Neighboring gene STARR-positive B cell enhancer mm9_chr10:92631736-92632037 Neighboring gene microRNA 1931 Neighboring gene STARR-seq mESC enhancer starr_27570 Neighboring gene STARR-seq mESC enhancer starr_27572 Neighboring gene STARR-seq mESC enhancer starr_27573 Neighboring gene ELK3, member of ETS oncogene family Neighboring gene predicted gene, 32604 Neighboring gene predicted gene, 32551

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The expression of ELK transcription factors in adult DRG: Novel isoforms, antisense transcripts and upregulation by nerve damage. Kerr N, et al. Mol Cell Neurosci, 2010 Jun. PMID 20304071, Free PMC Article
  2. ik3-1/Cables is associated with Trap and Pctaire2. Yamochi T, et al. Biochem Biophys Res Commun, 2001 Sep 7. PMID 11527406
  3. PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Okuda T, et al. Oncogene, 1992 Nov. PMID 1437147
  4. Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development. Mokalled MH, et al. Development, 2010 Jul. PMID 20534669, Free PMC Article
  5. The Role of CDKs and CDKIs in Murine Development. Campbell GJ, et al. Int J Mol Sci, 2020 Jul 28. PMID 32731332, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC25109

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cyclin-dependent kinase 17
Names
PCTAIRE-motif protein kinase 2
Pctaire2
cell division protein kinase 17
serine/threonine-protein kinase PCTAIRE-2
NP_666351.2
XP_006513689.1
XP_006513690.1
XP_011241749.1
XP_030100944.1
XP_030100945.1
XP_036011671.1
XP_036011672.1
XP_036011673.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146239.2 → NP_666351.2  cyclin-dependent kinase 17

    See identical proteins and their annotated locations for NP_666351.2

    Status: VALIDATED

    Source sequence(s)
    BB085519, BC064815, BQ442862, BU841444, BY130550, CD350146, CJ117086, CX242491, DV646930
    Consensus CDS
    CCDS48670.1
    UniProtKB/Swiss-Prot
    Q8K0D0
    UniProtKB/TrEMBL
    A0A1L1SUS7
    Related
    ENSMUSP00000070355.8, ENSMUST00000069965.9
    Conserved Domains (1) summary
    cd07872
    Location:185 → 493
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    92996492..93086956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155778.1 → XP_036011671.1  cyclin-dependent kinase 17 isoform X4

    UniProtKB/TrEMBL
    A0A1L1SUS7
    Related
    ENSMUSP00000150873.2, ENSMUST00000215286.2
    Conserved Domains (1) summary
    cd07872
    Location:185 → 493
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

  2. XM_030245085.1 → XP_030100945.1  cyclin-dependent kinase 17 isoform X5

    UniProtKB/TrEMBL
    A0A1L1SUS7
    Conserved Domains (1) summary
    cd07872
    Location:101 → 409
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

  3. XM_011243447.3 → XP_011241749.1  cyclin-dependent kinase 17 isoform X3

    See identical proteins and their annotated locations for XP_011241749.1

    UniProtKB/Swiss-Prot
    Q8K0D0
    UniProtKB/TrEMBL
    A0A1L1SUS7
    Conserved Domains (1) summary
    cd07872
    Location:185 → 493
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

  4. XM_006513627.4 → XP_006513690.1  cyclin-dependent kinase 17 isoform X3

    See identical proteins and their annotated locations for XP_006513690.1

    UniProtKB/Swiss-Prot
    Q8K0D0
    UniProtKB/TrEMBL
    A0A1L1SUS7
    Conserved Domains (1) summary
    cd07872
    Location:185 → 493
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

  5. XM_030245084.2 → XP_030100944.1  cyclin-dependent kinase 17 isoform X2

    UniProtKB/TrEMBL
    A0A1L1SUS7
    Conserved Domains (1) summary
    cd07872
    Location:201 → 509
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

  6. XM_006513626.3 → XP_006513689.1  cyclin-dependent kinase 17 isoform X1

    UniProtKB/TrEMBL
    A0A1L1SUS7
    Conserved Domains (1) summary
    cd07872
    Location:201 → 509
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

  7. XM_036155780.1 → XP_036011673.1  cyclin-dependent kinase 17 isoform X6

    UniProtKB/TrEMBL
    A0A1L1SUS7, I6L9D3
    Conserved Domains (1) summary
    cd07872
    Location:101 → 409
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

  8. XM_036155779.1 → XP_036011672.1  cyclin-dependent kinase 17 isoform X5

    UniProtKB/TrEMBL
    A0A1L1SUS7
    Conserved Domains (1) summary
    cd07872
    Location:101 → 409
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

RNA

  1. XR_003948686.1 RNA Sequence

  2. XR_003948687.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0D0.2 GenPept UniProtKB/Swiss-Prot:Q8K0D0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous