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Gas2l3 growth arrest-specific 2 like 3 [ Mus musculus (house mouse) ]

Gene ID: 237436, updated on 5-Mar-2024

Summary

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Official Symbol
Gas2l3provided by MGI
Official Full Name
growth arrest-specific 2 like 3provided by MGI
Primary source
MGI:MGI:1918780
See related
Ensembl:ENSMUSG00000074802 AllianceGenome:MGI:1918780
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm240; 8430435B07Rik
Summary
Predicted to enable actin filament binding activity; cytoskeletal anchor activity; and microtubule binding activity. Acts upstream of or within response to bacterium. Predicted to be located in actin cytoskeleton and microtubule cytoskeleton. Predicted to be active in actin filament. Orthologous to human GAS2L3 (growth arrest specific 2 like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 3.1), CNS E11.5 (RPKM 1.9) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Gas2l3 in Genome Data Viewer
Location:
10 C2; 10 44.98 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (89244684..89279935, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (89408822..89443980, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 (iodide transporter), member 8 Neighboring gene STARR-seq mESC enhancer starr_27514 Neighboring gene STARR-seq mESC enhancer starr_27515 Neighboring gene anoctamin 4 Neighboring gene predicted gene, 30769 Neighboring gene STARR-seq mESC enhancer starr_27517 Neighboring gene STARR-positive B cell enhancer ABC_E6898 Neighboring gene STARR-seq mESC enhancer starr_27520 Neighboring gene STARR-positive B cell enhancer ABC_E1404 Neighboring gene STARR-seq mESC enhancer starr_27521 Neighboring gene nuclear receptor subfamily 1, group H, member 4 Neighboring gene solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes. Gründl M, et al. PLoS Genet, 2020 May. PMID 32469866, Free PMC Article
  2. Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development. Stopp S, et al. Proc Natl Acad Sci U S A, 2017 Jul 25. PMID 28698371, Free PMC Article
  3. Single-cell transcriptomic analysis of mouse neocortical development. Loo L, et al. Nat Commun, 2019 Jan 11. PMID 30635555, Free PMC Article
  4. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
  5. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal anchor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin crosslink formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GAS2-like protein 3
Names
growth arrest-specific protein 2-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033331.2 → NP_001028503.2  GAS2-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001028503.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC152417, AK136054, BY205636, CF165165
    Consensus CDS
    CCDS24115.1
    UniProtKB/Swiss-Prot
    Q3TCF5, Q3UWW6
    UniProtKB/TrEMBL
    A0A0R4J1A6
    Related
    ENSMUSP00000100935.2, ENSMUST00000105298.3
    Conserved Domains (3) summary
    cd00014
    Location:51 → 169
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam05109
    Location:335 → 682
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02187
    Location:215 → 283
    GAS2; Growth-Arrest-Specific Protein 2 Domain

  2. NM_001079876.1 → NP_001073345.1  GAS2-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001073345.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, resulting in a 3-nt longer 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC152417, AK136054, BY205636, BY208646, CF165165
    Consensus CDS
    CCDS24115.1
    UniProtKB/Swiss-Prot
    Q3TCF5, Q3UWW6
    UniProtKB/TrEMBL
    A0A0R4J1A6
    Related
    ENSMUSP00000096973.3, ENSMUST00000099374.9
    Conserved Domains (3) summary
    cd00014
    Location:51 → 169
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam05109
    Location:335 → 682
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02187
    Location:215 → 283
    GAS2; Growth-Arrest-Specific Protein 2 Domain

  3. NM_001284344.1 → NP_001271273.1  GAS2-like protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001271273.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a split 3' exon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC152417, AK136054, AK164505, BY205636
    Consensus CDS
    CCDS88068.1
    UniProtKB/TrEMBL
    Q3TPC3
    Related
    ENSMUSP00000151240.2, ENSMUST00000220128.2
    Conserved Domains (2) summary
    cd00014
    Location:51 → 169
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam02187
    Location:216 → 283
    GAS2; Growth-Arrest-Specific Protein 2 Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    89244684..89279935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243445.3 → XP_011241747.1  GAS2-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011241747.1

    UniProtKB/Swiss-Prot
    Q3TCF5, Q3UWW6
    UniProtKB/TrEMBL
    A0A0R4J1A6
    Conserved Domains (3) summary
    cd00014
    Location:51 → 169
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam05109
    Location:335 → 682
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02187
    Location:215 → 283
    GAS2; Growth-Arrest-Specific Protein 2 Domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UWW6.1 GenPept UniProtKB/Swiss-Prot:Q3UWW6

Gene LinkOut

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