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Gm4924 predicted gene 4924 [ Mus musculus (house mouse) ]

Gene ID: 237412, updated on 8-Feb-2024

Summary

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Official Symbol
Gm4924provided by MGI
Official Full Name
predicted gene 4924provided by MGI
Primary source
MGI:MGI:3643133
See related
Ensembl:ENSMUSG00000073427 AllianceGenome:MGI:3643133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mif1; EG237412
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (82190087..82215477)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (82354525..82379643)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8352 Neighboring gene zinc finger protein 938 Neighboring gene STARR-seq mESC enhancer starr_27359 Neighboring gene SPATA31 subfamily H member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr10:81816788-81817089 Neighboring gene STARR-seq mESC enhancer starr_27361 Neighboring gene mitogen-activated protein kinase kinase kinase 7 pseudogene Neighboring gene predicted gene 1553

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Macrophage Migration Inhibitory Factor contributes to drive phenotypic and functional macrophages activation in response to Toxoplasma gondii infection. Ferreira PTM, et al. Immunobiology, 2023 May. PMID 36857907
  2. "Near Cure" treatment of severe acute EAE in MIF-1-deficient female and male mice with a bifunctional MHCII-derived molecular construct. Vandenbark AA, et al. Cell Immunol, 2022 Aug. PMID 35738135, Free PMC Article
  3. A novel Krüppel related factor consisting of only a KRAB domain is expressed in the murine trigeminal ganglion. Nikulina K, et al. Biochem Biophys Res Commun, 2006 Sep 29. PMID 16904636
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Macrophage Migration Inhibitory Factor contributes to drive phenotypic and functional macrophages activation in response to Toxoplasma gondii infection.
    Title: Macrophage Migration Inhibitory Factor contributes to drive phenotypic and functional macrophages activation in response to Toxoplasma gondii infection.
  2. ""Near Cure"" treatment of severe acute EAE in MIF-1-deficient female and male mice with a bifunctional MHCII-derived molecular construct.
    Title: "Near Cure" treatment of severe acute EAE in MIF-1-deficient female and male mice with a bifunctional MHCII-derived molecular construct.
  3. Novel murine Kruppel-related factor MIF1 expressed in trigeminal ganglion contains a Kruppel-associated box (KRAB) domain but lacks a zinc-finger motif.
    Title: A novel Krüppel related factor consisting of only a KRAB domain is expressed in the murine trigeminal ganglion.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
predicted gene 4924
Names
inhibitor of four 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001407604.1 → NP_001394533.1  predicted gene 4924 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158606, AC160865
    UniProtKB/TrEMBL
    A0A1B0GR71
    Related
    ENSMUSP00000147402.2, ENSMUST00000210381.2

  2. NM_001407606.1 → NP_001394535.1  predicted gene 4924 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158606, AC160865

  3. NM_001407607.1 → NP_001394536.1  predicted gene 4924 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158606, AC160865

  4. NM_001407609.1 → NP_001394538.1  predicted gene 4924 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158606, AC160865

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    82190087..82215477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314181.1 → XP_017169670.1  predicted gene 4924 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:599 → 1008
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:689 → 709
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:43 → 84
    KRAB; KRAB box

  2. XM_036156142.1 → XP_036012035.1  predicted gene 4924 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:349 → 756
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:381 → 401
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:43 → 84
    KRAB; KRAB box
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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