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Lingo3 leucine rich repeat and Ig domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 237403, updated on 5-Mar-2024

Summary

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Official Symbol
Lingo3provided by MGI
Official Full Name
leucine rich repeat and Ig domain containing 3provided by MGI
Primary source
MGI:MGI:3609246
See related
Ensembl:ENSMUSG00000051067 AllianceGenome:MGI:3609246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LERN2
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including branchial arch; embryo mesenchyme; eye; heart; and trigeminal preganglion. Orthologous to human LINGO3 (leucine rich repeat and Ig domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 10.8), adrenal adult (RPKM 5.6) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80668635..80679873, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80832801..80844039, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene junctional sarcoplasmic reticulum protein 1 Neighboring gene STARR-seq mESC enhancer starr_27299 Neighboring gene STARR-positive B cell enhancer ABC_E369 Neighboring gene microRNA 1982 Neighboring gene ornithine decarboxylase antizyme 1 Neighboring gene STARR-positive B cell enhancer ABC_E11447 Neighboring gene STARR-positive B cell enhancer ABC_E6885 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene signal peptide peptidase like 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of the Lingo/LERN gene family during mouse embryogenesis. Haines BP, et al. Gene Expr Patterns, 2008 Jan. PMID 18297755
  2. Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Homma S, et al. Gene Expr Patterns, 2009 Jan. PMID 18848646
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. The transcriptional landscape of the mammalian genome. Carninci P, et al. Science, 2005 Sep 2. PMID 16141072

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3
Names
leucine-rich repeat neuronal protein 6B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013758.2 → NP_001013780.2  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 precursor

    See identical proteins and their annotated locations for NP_001013780.2

    Status: VALIDATED

    Source sequence(s)
    BC072620, CJ131945
    Consensus CDS
    CCDS24035.1
    UniProtKB/Swiss-Prot
    E9QK50, Q6GQU6
    Related
    ENSMUSP00000054960.8, ENSMUST00000053986.9
    Conserved Domains (6) summary
    TIGR00864
    Location:331 → 405
    PCC; polycystin cation channel protein
    smart00013
    Location:23 → 55
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:55 → 353
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:34 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:246 → 302
    LRR_8; Leucine rich repeat
    pfam07679
    Location:406 → 496
    I-set; Immunoglobulin I-set domain

  2. NM_001359746.1 → NP_001346675.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 precursor

    Status: VALIDATED

    Source sequence(s)
    BC072620, CJ070128, CK620157
    Consensus CDS
    CCDS24035.1
    UniProtKB/Swiss-Prot
    E9QK50, Q6GQU6
    Conserved Domains (6) summary
    TIGR00864
    Location:331 → 405
    PCC; polycystin cation channel protein
    smart00013
    Location:23 → 55
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:55 → 353
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:34 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:246 → 302
    LRR_8; Leucine rich repeat
    pfam07679
    Location:406 → 496
    I-set; Immunoglobulin I-set domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80668635..80679873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513623.4 → XP_006513686.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006513686.1

    UniProtKB/Swiss-Prot
    E9QK50, Q6GQU6
    Conserved Domains (6) summary
    TIGR00864
    Location:331 → 405
    PCC; polycystin cation channel protein
    smart00013
    Location:23 → 55
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:55 → 353
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:34 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:246 → 302
    LRR_8; Leucine rich repeat
    pfam07679
    Location:406 → 496
    I-set; Immunoglobulin I-set domain

  2. XM_006513622.5 → XP_006513685.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006513685.1

    UniProtKB/Swiss-Prot
    E9QK50, Q6GQU6
    Conserved Domains (6) summary
    TIGR00864
    Location:331 → 405
    PCC; polycystin cation channel protein
    smart00013
    Location:23 → 55
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:55 → 353
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:34 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:246 → 302
    LRR_8; Leucine rich repeat
    pfam07679
    Location:406 → 496
    I-set; Immunoglobulin I-set domain

  3. XM_006513620.5 → XP_006513683.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006513683.1

    UniProtKB/Swiss-Prot
    E9QK50, Q6GQU6
    Conserved Domains (6) summary
    TIGR00864
    Location:331 → 405
    PCC; polycystin cation channel protein
    smart00013
    Location:23 → 55
    LRRNT; Leucine rich repeat N-terminal domain
    COG4886
    Location:55 → 353
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:34 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:246 → 302
    LRR_8; Leucine rich repeat
    pfam07679
    Location:406 → 496
    I-set; Immunoglobulin I-set domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GQU6.2 GenPept UniProtKB/Swiss-Prot:Q6GQU6

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