Mex3d mex3 RNA binding family member D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mex3dprovided by MGI
Official Full Name: mex3 RNA binding family member Dprovided by MGI
Primary source: MGI:MGI:2681847
See related: Ensembl:ENSMUSG00000048696 AllianceGenome:MGI:2681847
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rkhd1
Summary: Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to act upstream of or within RNA destabilization and mRNA catabolic process. Predicted to be located in nucleus and perinuclear region of cytoplasm. Orthologous to human MEX3D (mex-3 RNA binding family member D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 193.1), ovary adult (RPKM 36.0) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (80216189..80223485, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (80380355..80387651, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA destabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mRNA destabilization	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA-binding protein MEX3D

Names: RING finger and KH domain-containing protein 1; mex3 homolog D; ring finger (C3HC4 type) and KH domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198615.2 → NP_941017.2 RNA-binding protein MEX3D

Status: VALIDATED

Source sequence(s)

AC152062, AK149801, BC059858, BX514891

Consensus CDS

CCDS48629.1

UniProtKB/Swiss-Prot

Q3UE17

UniProtKB/TrEMBL

D3YTR3, E9PUA0

Related

ENSMUSP00000100987.3, ENSMUST00000105350.3

Conserved Domains (3) summary

smart00322
Location:328 → 393

KH; K homology RNA-binding domain

cd00105
Location:235 → 296

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam13920
Location:665 → 712

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

80216189..80223485 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513619.4 → XP_006513682.1 RNA-binding protein MEX3D isoform X1

UniProtKB/Swiss-Prot

Q3UE17

Conserved Domains (5) summary

smart00322
Location:328 → 393

KH; K homology RNA-binding domain

PHA03247
Location:27 → 215

PHA03247; large tegument protein UL36; Provisional

cd00105
Location:235 → 296

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd00162
Location:667 → 706

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

cl17238
Location:665 → 709

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain