Npffr1 neuropeptide FF receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npffr1provided by MGI
Official Full Name: neuropeptide FF receptor 1provided by MGI
Primary source: MGI:MGI:2685082
See related: Ensembl:ENSMUSG00000020090 AllianceGenome:MGI:2685082
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm236; NPFF1; Gpr147; NPFF1R; OT7T022
Summary: Predicted to enable G protein-coupled receptor activity and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in cilium. Predicted to be integral component of plasma membrane. Orthologous to human NPFFR1 (neuropeptide FF receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 32.24 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (61430600..61465243)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (61595295..61629464)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RFRP-3 activated PI3K/AKT and ERK1/2 signaling cascades and promotes pancreatic alpha cell survival, likely via GPR147.
Title: RFamide-related peptide-3 promotes alpha TC1 clone 6 cell survival likely via GPR147.
Our data support a discernible orexigenic role of NPFF1R signaling selectively in males, which might modulate the effects of leptin and ghrelin on food intake
Title: Sex-Biased Physiological Roles of NPFF1R, the Canonical Receptor of RFRP-3, in Food Intake and Metabolic Homeostasis Revealed by its Congenital Ablation in mice.
kisspeptin can act partly through neuropeptide FF receptors to modulate neuronal activity independent of GPR54 in the mouse brain.
Title: Kisspeptin regulation of arcuate neuron excitability in kisspeptin receptor knockout mice.
In keeping with its inhibitory role, the NPFF1R pathway seems dispensable for preserved puberty and fertility in the NPFF1 receptor null mouse.
Title: Physiological roles of gonadotropin-inhibitory hormone signaling in the control of mammalian reproductive axis: studies in the NPFF1 receptor null mouse.
Data showed that 33% of GnRH neurons and 9-16% of rostral periventricular kisspeptin neurons expressed Gpr147, whereas Gpr74 was not expressed in either population.
Title: RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action.
RFRP-3 may exert its effects on reproduction either directly, via Gpr147 in a subset of GnRH neurons, and/or indirectly, via upstream regulators of GnRH.
Title: Development, sex steroid regulation, and phenotypic characterization of RFamide-related peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus.
central NPFF1 and NPFF2 receptors control in an opposite manner the body temperature in mice.
Title: Opposite control of body temperature by NPFF1 and NPFF2 receptors in mice.
The constant presence of NPFF1 receptors in the septum, the nucleus of the tractus solitarius, and the hypothalamus suggest its participation in neuroendocrine functions.
Title: Detailed distribution of neuropeptide FF receptors (NPFF1 and NPFF2) in the rat, mouse, octodon, rabbit, guinea pig, and marmoset monkey brains: a comparative autoradiographic study.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (5)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuropeptide FF receptor 1

Names: G protein-coupled receptor 147; G-protein coupled receptor NPFF1R; RFamide-related peptide receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177511.2 → NP_001170982.1 neuropeptide FF receptor 1

Status: VALIDATED

Source sequence(s)

AC124421

Consensus CDS

CCDS48574.1

UniProtKB/TrEMBL

E9Q468

Related

ENSMUSP00000020287.6, ENSMUST00000020287.8

Conserved Domains (2) summary

pfam00001
Location:60 → 331

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:54 → 173

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

61430600..61465243

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243444.4 → XP_011241746.1 neuropeptide FF receptor 1 isoform X1

Conserved Domains (2) summary

cd14964
Location:1 → 29

7tm_GPCRs; TM helix 3 [structural motif]

cl28897
Location:1 → 225

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily