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Adamts14 ADAM metallopeptidase with thrombospondin type 1 motif 14 [ Mus musculus (house mouse) ]

Gene ID: 237360, updated on 5-Mar-2024

Summary

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Official Symbol
Adamts14provided by MGI
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 14provided by MGI
Primary source
MGI:MGI:2179942
See related
Ensembl:ENSMUSG00000059901 AllianceGenome:MGI:2179942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TS14; Adamts-14
Summary
Enables peptidase activity. Acts upstream of or within collagen fibril organization. Located in extracellular region. Is expressed in vertebral axis musculature. Human ortholog(s) of this gene implicated in osteoarthritis; primary progressive multiple sclerosis; and relapsing-remitting multiple sclerosis. Orthologous to human ADAMTS14 (ADAM metallopeptidase with thrombospondin type 1 motif 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 4.5), spleen adult (RPKM 3.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B4; 10 32.16 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (61032886..61109447, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (61197112..61273419, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene sphingosine phosphate lyase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8337 Neighboring gene STARR-positive B cell enhancer mm9_chr10:60610293-60610594 Neighboring gene STARR-seq mESC enhancer starr_26826 Neighboring gene thymus, brain and testes associated Neighboring gene STARR-positive B cell enhancer mm9_chr10:60662268-60662569 Neighboring gene predicted gene, 29861 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:60697146-60697393 Neighboring gene ribosomal protein L27A, pseudogene 1 Neighboring gene perforin 1 (pore forming protein)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14. Dupont L, et al. Matrix Biol, 2018 Sep. PMID 29649548
  2. Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain. Rosell-García T, et al. J Biol Chem, 2019 Jul 19. PMID 31152061, Free PMC Article
  3. Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3. Colige A, et al. J Biol Chem, 2002 Feb 22. PMID 11741898
  4. Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis. Le Goff C, et al. Development, 2006 Apr. PMID 16556917
  5. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function.
    Title: Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function.
  2. Mice lacking Adamts2 and Adamts14 develop spontaneous atopic dermatitis due to immune dysregulation.
    Title: Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within collagen fibril organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 14
Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081127.2 → NP_001074596.1  A disintegrin and metalloproteinase with thrombospondin motifs 14 precursor

    See identical proteins and their annotated locations for NP_001074596.1

    Status: VALIDATED

    Source sequence(s)
    AC123530, AC151895
    Consensus CDS
    CCDS35915.1
    UniProtKB/TrEMBL
    B2RXR8, B2RXX5, E9PX39
    Related
    ENSMUSP00000090143.5, ENSMUST00000092486.11
    Conserved Domains (6) summary
    smart00209
    Location:542 → 594
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:246 → 444
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam00090
    Location:961 → 1008
    TSP_1; Thrombospondin type 1 domain
    pfam01421
    Location:248 → 447
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:80 → 193
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:701 → 816
    ADAM_spacer1; ADAM-TS Spacer 1

RNA

  1. NR_157278.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC151895, AK137573, AW120521, BC172106

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    61032886..61109447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155775.1 → XP_036011668.1  A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform X1

    UniProtKB/TrEMBL
    B2RXR8
    Conserved Domains (6) summary
    smart00209
    Location:542 → 594
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:246 → 444
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:701 → 816
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:80 → 194
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:459 → 528
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:838 → 893
    TSP1_ADAMTS; Thrombospondin type 1 domain
Nucleotide Protein Strain
Heading Accession and Version

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