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Aldh8a1 aldehyde dehydrogenase 8 family, member A1 [ Mus musculus (house mouse) ]

Gene ID: 237320, updated on 5-Mar-2024

Summary

Official Symbol
Aldh8a1provided by MGI
Official Full Name
aldehyde dehydrogenase 8 family, member A1provided by MGI
Primary source
MGI:MGI:2653900
See related
Ensembl:ENSMUSG00000037542 AllianceGenome:MGI:2653900
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Raldh4
Summary
Enables retinal dehydrogenase activity. Acts upstream of or within 9-cis-retinoic acid biosynthetic process. Predicted to be located in cytoplasm. Is expressed in cochlea; inner ear; inner ear vestibular component; liver; and liver lobe. Orthologous to human ALDH8A1 (aldehyde dehydrogenase 8 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 83.6), kidney adult (RPKM 72.6) and 3 other tissues See more
Orthologs
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Genomic context

Location:
10 A3; 10 9.75 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (21253199..21272477)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (21377300..21396578)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930455C13 gene Neighboring gene Hbs1-like (S. cerevisiae) Neighboring gene predicted gene, 33803 Neighboring gene STARR-seq mESC enhancer starr_25987 Neighboring gene FK506 binding protein 1a, pseudogene 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:21139015-21139198 Neighboring gene STARR-seq mESC enhancer starr_25988 Neighboring gene predicted gene, 33945 Neighboring gene predicted gene, 33892

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

General protein information

Preferred Names
2-aminomuconic semialdehyde dehydrogenase
Names
aldehyde dehydrogenase family 8 member A1
retinal dehydrogenase 4
retinal dehydrogenase type 4
NP_848828.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178713.4NP_848828.1  2-aminomuconic semialdehyde dehydrogenase

    See identical proteins and their annotated locations for NP_848828.1

    Status: VALIDATED

    Source sequence(s)
    AC153557, AK050298
    Consensus CDS
    CCDS23723.1
    UniProtKB/Swiss-Prot
    Q8BH00, Q91WS6
    Related
    ENSMUSP00000038878.8, ENSMUST00000042699.14
    Conserved Domains (1) summary
    cd07093
    Location:27485
    ALDH_F8_HMSADH; Human aldehyde dehydrogenase family 8 member A1-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    21253199..21272477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)