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Il20ra interleukin 20 receptor, alpha [ Mus musculus (house mouse) ]

Gene ID: 237313, updated on 12-May-2024

Summary

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Official Symbol
Il20raprovided by MGI
Official Full Name
interleukin 20 receptor, alphaprovided by MGI
Primary source
MGI:MGI:3605069
See related
Ensembl:ENSMUSG00000020007 AllianceGenome:MGI:3605069
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E230031K19
Summary
Enables interleukin-20 binding activity. Acts upstream of or within cytokine-mediated signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; and regulation of bone resorption. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in epididymis; eye; and ileum. Orthologous to human IL20RA (interleukin 20 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
10 A3; 10 8.76 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (19587421..19635801)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (19711673..19760053)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2317 Neighboring gene interferon gamma receptor 1 Neighboring gene interleukin 22 receptor, alpha 2 Neighboring gene STARR-seq mESC enhancer starr_25939 Neighboring gene predicted gene, 33332 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19411574-19411868 Neighboring gene predicted gene, 25256 Neighboring gene solute carrier family 35, member D3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models. Lu SW, et al. Nat Commun, 2020 Sep 14. PMID 32929072, Free PMC Article
  2. Mouse interleukin-20 receptor 1a targets renal epithelial cells and is associated with renal calcium deposition. Wei CC, et al. Genes Immun, 2009 Apr. PMID 19078987
  3. Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway Inflammation. Weng YH, et al. Front Immunol, 2019. PMID 31114590, Free PMC Article
  4. Detection of IL-20R1 and IL-20R2 mRNA in C57BL/6 mice astroglial cells and brain cortex following LPS stimulation. Abd Nikfarjam B, et al. Iran J Immunol, 2013 Jun. PMID 23811545
  5. Interleukin-19 mediates tissue damage in murine ischemic acute kidney injury. Hsu YH, et al. PLoS One, 2013. PMID 23468852, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-20R1 and IL-20R2 are constitutively express in the brain.
    Title: Detection of IL-20R1 and IL-20R2 mRNA in C57BL/6 mice astroglial cells and brain cortex following LPS stimulation.
  2. mIL-20R1a functioned as an aggravating factor in promoting calcium deposition in kidney of mice.
    Title: Mouse interleukin-20 receptor 1a targets renal epithelial cells and is associated with renal calcium deposition.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-20 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-20 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interleukin-20 receptor subunit alpha
Names
IL-20 receptor subunit alpha
IL-20R-alpha
IL-20R1
IL-20RA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172786.2 → NP_766374.1  interleukin-20 receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_766374.1

    Status: PROVISIONAL

    Source sequence(s)
    AK054215
    Consensus CDS
    CCDS23718.1
    UniProtKB/Swiss-Prot
    Q6PHB0, Q8BW64
    Related
    ENSMUSP00000020185.4, ENSMUST00000020185.5
    Conserved Domains (2) summary
    pfam01108
    Location:29 → 126
    Tissue_fac; Tissue factor
    pfam09294
    Location:138 → 242
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    19587421..19635801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512726.1 → XP_006512789.1  interleukin-20 receptor subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_006512789.1

    UniProtKB/Swiss-Prot
    Q6PHB0, Q8BW64
    Conserved Domains (2) summary
    pfam01108
    Location:29 → 126
    Tissue_fac; Tissue factor
    pfam09294
    Location:138 → 242
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

  2. XM_011243169.2 → XP_011241471.1  interleukin-20 receptor subunit alpha isoform X3

    Conserved Domains (1) summary
    pfam09294
    Location:25 → 128
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

  3. XM_006512729.2 → XP_006512792.1  interleukin-20 receptor subunit alpha isoform X2

    See identical proteins and their annotated locations for XP_006512792.1

    Conserved Domains (1) summary
    pfam09294
    Location:4 → 108
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

  4. XM_006512728.5 → XP_006512791.1  interleukin-20 receptor subunit alpha isoform X2

    See identical proteins and their annotated locations for XP_006512791.1

    Conserved Domains (1) summary
    pfam09294
    Location:4 → 108
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PHB0.2 GenPept UniProtKB/Swiss-Prot:Q6PHB0

Gene LinkOut

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