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Gnl3l guanine nucleotide binding protein nucleolar 3 like [ Mus musculus (house mouse) ]

Gene ID: 237107, updated on 5-Mar-2024

Summary

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Official Symbol
Gnl3lprovided by MGI
Official Full Name
guanine nucleotide binding protein nucleolar 3 likeprovided by MGI
Primary source
MGI:MGI:2448557
See related
Ensembl:ENSMUSG00000025266 AllianceGenome:MGI:2448557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable GTP binding activity. Predicted to be involved in several processes, including negative regulation of protein modification by small protein conjugation or removal; negative regulation of telomere maintenance via telomerase; and positive regulation of protein localization to chromosome, telomeric region. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of telomerase holoenzyme complex. Predicted to be active in nucleolus. Orthologous to human GNL3L (G protein nucleolar 3 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 22.1), frontal lobe adult (RPKM 21.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X F3; X 68.46 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (149766129..149800318, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (150983133..151017322, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54086 Neighboring gene inter-alpha-trypsin inhibitor heavy chain family member 6 Neighboring gene STARR-seq mESC enhancer starr_48073 Neighboring gene polypyrimidine tract binding protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8765 Neighboring gene STARR-seq mESC enhancer starr_48075 Neighboring gene predicted gene, 46690 Neighboring gene FYVE, RhoGEF and PH domain containing 1 Neighboring gene TSR2 20S rRNA accumulation

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GNL3L inhibits activity of estrogen-related receptor gamma by competing for coactivator binding. Yasumoto H, et al. J Cell Sci, 2007 Aug 1. PMID 17623774, Free PMC Article
  2. GNL3L stabilizes the TRF1 complex and promotes mitotic transition. Zhu Q, et al. J Cell Biol, 2009 Jun 1. PMID 19487455, Free PMC Article
  3. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article
  4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  5. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. Valdez-Sinon AN, et al. iScience, 2020 May 22. PMID 32434143, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of GNL3L Alleviates the Progression of COPD Through Inhibiting the ATM/p53 Pathway.
    Title: Knockdown of GNL3L Alleviates the Progression of COPD Through Inhibiting the ATM/p53 Pathway.
  2. GNL3L mediates the mitotic increase of TRF1 protein and promotes the metaphase-to-anaphase transition.
    Title: GNL3L stabilizes the TRF1 complex and promotes mitotic transition.
  3. work reveals a novel mechanism that negatively regulates the transcriptional function of ERRgamma (estrogen-related receptor)by GNL3L through coactivator competition.
    Title: GNL3L inhibits activity of estrogen-related receptor gamma by competing for coactivator binding.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein-like 3-like protein
Names
guanine nucleotide binding protein-like 3 (nucleolar)-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168600.1 → NP_001162071.1  guanine nucleotide-binding protein-like 3-like protein

    See identical proteins and their annotated locations for NP_001162071.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL805937, BY640210, CJ066167
    Consensus CDS
    CCDS41174.1
    UniProtKB/Swiss-Prot
    Q6PGG6
    Related
    ENSMUSP00000026297.6, ENSMUST00000026297.12
    Conserved Domains (3) summary
    PTZ00121
    Location:19 → 166
    PTZ00121; MAEBL; Provisional
    cd04178
    Location:129 → 301
    Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
    COG0012
    Location:246 → 384
    GTP1; Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis]

  2. NM_198110.2 → NP_932778.1  guanine nucleotide-binding protein-like 3-like protein

    See identical proteins and their annotated locations for NP_932778.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2)represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BB644039, BC057033, BY640210
    Consensus CDS
    CCDS41174.1
    UniProtKB/Swiss-Prot
    Q6PGG6
    Related
    ENSMUSP00000108311.3, ENSMUST00000112691.9
    Conserved Domains (3) summary
    PTZ00121
    Location:19 → 166
    PTZ00121; MAEBL; Provisional
    cd04178
    Location:129 → 301
    Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
    COG0012
    Location:246 → 384
    GTP1; Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    149766129..149800318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528805.5 → XP_006528868.1  guanine nucleotide-binding protein-like 3-like protein isoform X1

    See identical proteins and their annotated locations for XP_006528868.1

    UniProtKB/Swiss-Prot
    Q6PGG6
    Conserved Domains (3) summary
    PTZ00121
    Location:19 → 166
    PTZ00121; MAEBL; Provisional
    cd04178
    Location:129 → 301
    Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
    COG0012
    Location:246 → 384
    GTP1; Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PGG6.1 GenPept UniProtKB/Swiss-Prot:Q6PGG6

Gene LinkOut

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