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Ercc6l excision repair cross-complementing rodent repair deficiency complementation group 6 like [ Mus musculus (house mouse) ]

Gene ID: 236930, updated on 5-Mar-2024

Summary

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Official Symbol
Ercc6lprovided by MGI
Official Full Name
excision repair cross-complementing rodent repair deficiency complementation group 6 likeprovided by MGI
Primary source
MGI:MGI:2654144
See related
Ensembl:ENSMUSG00000051220 AllianceGenome:MGI:2654144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D330021P09Rik
Summary
Predicted to enable DNA translocase activity. Predicted to act upstream of or within cell division. Predicted to be located in kinetochore. Is expressed in several structures, including adrenal medulla; liver; lung; nervous system; and trunk. Orthologous to human ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 4.8), CNS E11.5 (RPKM 4.2) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X D; X 45.16 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (101186426..101200697, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (102142820..102157091, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin) Neighboring gene high mobility group protein B1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2538 Neighboring gene protein phosphatase 1 regulatory subunit 14B pseudogene Neighboring gene ribosomal protein S4, X-linked

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ercc6l, a gene of SNF2 family, may play a role in the teratogenic action of alcohol. Xu Y, et al. Toxicol Lett, 2005 Jul 4. PMID 15917148
  2. Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality. Albers E, et al. Cell Rep, 2018 Sep 18. PMID 30232008, Free PMC Article
  3. Gene expression profiling identifies eleven DNA repair genes down-regulated during mouse neural crest cell migration. Albino D, et al. Int J Dev Biol, 2011. PMID 21425081
  4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ercc6l is essential to preserve chromosomal integrity during embryonic development.
    Title: Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7766

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA translocase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA translocase activity ISO
Inferred from Sequence Orthology
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA excision repair protein ERCC-6-like
Names
ATP-dependent helicase ERCC6-like
SNF2/RAD54 family protein
excision repair cross-complementing rodent repair deficiency complementation group 6 - like
NP_666347.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146235.3 → NP_666347.2  DNA excision repair protein ERCC-6-like

    See identical proteins and their annotated locations for NP_666347.2

    Status: VALIDATED

    Source sequence(s)
    AK029015, AL807784
    Consensus CDS
    CCDS30321.1
    UniProtKB/Swiss-Prot
    Q8BGN1, Q8BHK9, Q8BRC9, Q8CE49
    Related
    ENSMUSP00000050592.3, ENSMUST00000056904.3
    Conserved Domains (3) summary
    cd00046
    Location:117 → 260
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:100 → 418
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:462 → 577
    Helicase_C; Helicase conserved C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    101186426..101200697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHK9.1 GenPept UniProtKB/Swiss-Prot:Q8BHK9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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