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Klhl15 kelch-like 15 [ Mus musculus (house mouse) ]

Gene ID: 236904, updated on 11-Apr-2024

Summary

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Official Symbol
Klhl15provided by MGI
Official Full Name
kelch-like 15provided by MGI
Primary source
MGI:MGI:1923400
See related
Ensembl:ENSMUSG00000043929 AllianceGenome:MGI:1923400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330500C13Rik
Summary
Predicted to be involved in negative regulation of double-strand break repair via homologous recombination and nuclear protein quality control by the ubiquitin-proteasome system. Predicted to be located in nucleus. Predicted to be part of Cul3-RING ubiquitin ligase complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 103. Orthologous to human KLHL15 (kelch like family member 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Klhl15 in Genome Data Viewer
Location:
X C3; X 41.53 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (93275884..93321330)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (94232278..94277724)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene zinc finger protein X-linked Neighboring gene predicted gene, 46691 Neighboring gene STARR-seq mESC enhancer starr_47557 Neighboring gene eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked Neighboring gene STARR-seq mESC enhancer starr_47559 Neighboring gene STARR-positive B cell enhancer ABC_E8763 Neighboring gene microRNA 7673 Neighboring gene predicted gene 5400 Neighboring gene predicted gene 14826

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • MGC47138

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear protein quality control by the ubiquitin-proteasome system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear protein quality control by the ubiquitin-proteasome system ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039059.1 → NP_001034148.1  kelch-like protein 15 isoform c

    See identical proteins and their annotated locations for NP_001034148.1

    Status: VALIDATED

    Source sequence(s)
    AK081546, AK165342, AK169500
    Consensus CDS
    CCDS41062.1
    UniProtKB/Swiss-Prot
    A2AAX3
    Related
    ENSMUSP00000109541.2, ENSMUST00000113908.8
    Conserved Domains (2) summary
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  2. NM_001039060.1 → NP_001034149.1  kelch-like protein 15 isoform b

    See identical proteins and their annotated locations for NP_001034149.1

    Status: VALIDATED

    Source sequence(s)
    AK081546, AK165342, AK169500
    Consensus CDS
    CCDS30279.1
    UniProtKB/Swiss-Prot
    A2AAX3
    Related
    ENSMUSP00000094097.4, ENSMUST00000096369.10
    Conserved Domains (3) summary
    smart00225
    Location:32 → 128
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:133 → 235
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:21 → 125
    BTB; BTB/POZ domain

  3. NM_001039061.1 → NP_001034150.1  kelch-like protein 15 isoform a

    See identical proteins and their annotated locations for NP_001034150.1

    Status: VALIDATED

    Source sequence(s)
    AK078112, AK081546, AK133055, AL646049
    Consensus CDS
    CCDS30278.1
    UniProtKB/Swiss-Prot
    A2AAX3, Q3TEP6, Q8K1Y4
    Related
    ENSMUSP00000109549.4, ENSMUST00000113916.10
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 576
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  4. NM_153165.2 → NP_694805.1  kelch-like protein 15 isoform c

    See identical proteins and their annotated locations for NP_694805.1

    Status: VALIDATED

    Source sequence(s)
    AK081546, AK165342, AK169500
    Consensus CDS
    CCDS41062.1
    UniProtKB/Swiss-Prot
    A2AAX3
    Related
    ENSMUSP00000109544.3, ENSMUST00000113911.9
    Conserved Domains (2) summary
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    93275884..93321330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527986.4 → XP_006528049.1  kelch-like protein 15 isoform X1

    See identical proteins and their annotated locations for XP_006528049.1

    UniProtKB/Swiss-Prot
    A2AAX3, Q3TEP6, Q8K1Y4
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 576
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  2. XM_006527989.4 → XP_006528052.1  kelch-like protein 15 isoform X1

    See identical proteins and their annotated locations for XP_006528052.1

    UniProtKB/Swiss-Prot
    A2AAX3, Q3TEP6, Q8K1Y4
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 576
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  3. XM_006527991.5 → XP_006528054.1  kelch-like protein 15 isoform X2

    See identical proteins and their annotated locations for XP_006528054.1

    UniProtKB/Swiss-Prot
    A2AAX3
    Conserved Domains (2) summary
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  4. XM_030251323.2 → XP_030107183.1  kelch-like protein 15 isoform X2

    Conserved Domains (2) summary
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  5. XM_030251322.2 → XP_030107182.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    A2AAX3, Q3TEP6, Q8K1Y4
    Related
    ENSMUSP00000129734.2, ENSMUST00000170594.8
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 576
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  6. XM_006527990.5 → XP_006528053.1  kelch-like protein 15 isoform X1

    See identical proteins and their annotated locations for XP_006528053.1

    UniProtKB/Swiss-Prot
    A2AAX3, Q3TEP6, Q8K1Y4
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 576
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  7. XM_006527987.4 → XP_006528050.1  kelch-like protein 15 isoform X1

    See identical proteins and their annotated locations for XP_006528050.1

    UniProtKB/Swiss-Prot
    A2AAX3, Q3TEP6, Q8K1Y4
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 576
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  8. XM_011247581.1 → XP_011245883.1  kelch-like protein 15 isoform X1

    See identical proteins and their annotated locations for XP_011245883.1

    UniProtKB/Swiss-Prot
    A2AAX3, Q3TEP6, Q8K1Y4
    Related
    ENSMUSP00000109548.2, ENSMUST00000113915.2
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 576
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)

  9. XM_036161925.1 → XP_036017818.1  kelch-like protein 15 isoform X1

    UniProtKB/Swiss-Prot
    A2AAX3, Q3TEP6, Q8K1Y4
    Conserved Domains (4) summary
    PHA03098
    Location:33 → 576
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:417 → 474
    Kelch; KELCH repeat [structural motif]
    cd18244
    Location:1 → 137
    BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)
    cd18454
    Location:128 → 235
    BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AAX3.1 GenPept UniProtKB/Swiss-Prot:A2AAX3

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