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Magea10 MAGE family member A10 [ Mus musculus (house mouse) ]

Gene ID: 236852, updated on 5-Mar-2024

Summary

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Official Symbol
Magea10provided by MGI
Official Full Name
MAGE family member A10provided by MGI
Primary source
MGI:MGI:3588211
See related
Ensembl:ENSMUSG00000043453 AllianceGenome:MGI:3588211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable caspase binding activity and histone deacetylase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; endoplasmic reticulum; and nuclear body. Predicted to be active in nucleus. Is expressed in several structures, including brain; egg cylinder; gonad; heart; and liver. Orthologous to several human genes including MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
X A7.3; X 37.23 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (71425476..71430464, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (72381870..72386858, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene microRNA 224 Neighboring gene gamma-aminobutyric acid (GABA) A receptor, subunit epsilon Neighboring gene microRNA 452 Neighboring gene STARR-seq mESC enhancer starr_47334 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha 3 Neighboring gene coiled-coil domain containing 99 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47335 Neighboring gene STARR-seq mESC enhancer starr_47336 Neighboring gene microRNA 767

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice. Hou S, et al. Sci Rep, 2016 May 26. PMID 27226137, Free PMC Article
  2. Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells. Gordeeva O, et al. Oncotarget, 2019 May 14. PMID 31143371, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
melanoma-associated antigen 10
Names
melanoma antigen family A, 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085506.1 → NP_001078975.1  melanoma-associated antigen 10

    Status: VALIDATED

    Source sequence(s)
    AK136064
    Consensus CDS
    CCDS41002.1
    UniProtKB/TrEMBL
    A2AMW4
    Related
    ENSMUSP00000085832.5, ENSMUST00000088481.5
    Conserved Domains (2) summary
    pfam01454
    Location:138 → 293
    MAGE; MAGE family
    pfam12440
    Location:52 → 100
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    71425476..71430464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318472.1 → XP_017173961.1  melanoma-associated antigen 10 isoform X1

    UniProtKB/TrEMBL
    A2AMW4
    Conserved Domains (2) summary
    pfam01454
    Location:138 → 293
    MAGE; MAGE family
    pfam12440
    Location:52 → 100
    MAGE_N; Melanoma associated antigen family N terminal
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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