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Ints6l integrator complex subunit 6 like [ Mus musculus (house mouse) ]

Gene ID: 236790, updated on 5-Mar-2024

Summary

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Official Symbol
Ints6lprovided by MGI
Official Full Name
integrator complex subunit 6 likeprovided by MGI
Primary source
MGI:MGI:2442593
See related
Ensembl:ENSMUSG00000035967 AllianceGenome:MGI:2442593
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ddx26b; D130066O12; 4930535D10Rik; 6330505F04Rik
Summary
Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. Orthologous to human INTS6L (integrator complex subunit 6 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 32.1), liver E14.5 (RPKM 25.2) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A5; X 30.06 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (55500180..55553201)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (56454825..56507843)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 10 like 2A Neighboring gene predicted gene 2155 Neighboring gene STARR-positive B cell enhancer ABC_E8761 Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene cancer/testis antigen 45 Neighboring gene microRNA 5116 Neighboring gene membrane magnesium transporter 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
integrator complex subunit 6-like
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
protein DDX26B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403599.1 → NP_001390528.1  integrator complex subunit 6-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC048362

  2. NM_001403600.1 → NP_001390529.1  integrator complex subunit 6-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC048362

  3. NM_001403601.1 → NP_001390530.1  integrator complex subunit 6-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC048362

  4. NM_001403602.1 → NP_001390531.1  integrator complex subunit 6-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC048362

  5. NM_001403604.1 → NP_001390533.1  integrator complex subunit 6-like isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC048362

  6. NM_001403605.1 → NP_001390534.1  integrator complex subunit 6-like isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC048362

  7. NM_001403606.1 → NP_001390535.1  integrator complex subunit 6-like isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC048362

  8. NM_172779.5 → NP_766367.1  integrator complex subunit 6-like isoform 2

    See identical proteins and their annotated locations for NP_766367.1

    Status: VALIDATED

    Source sequence(s)
    AC048362
    Consensus CDS
    CCDS30145.1
    UniProtKB/Swiss-Prot
    Q8BND4
    Related
    ENSMUSP00000035379.3, ENSMUST00000039374.9
    Conserved Domains (2) summary
    pfam13519
    Location:4 → 103
    VWA_2; von Willebrand factor type A domain
    pfam15300
    Location:777 → 838
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    55500180..55553201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161922.1 → XP_036017815.1  integrator complex subunit 6-like isoform X6

    Conserved Domains (1) summary
    pfam13519
    Location:4 → 103
    VWA_2; von Willebrand factor type A domain

  2. XM_036161918.1 → XP_036017811.1  integrator complex subunit 6-like isoform X2

    UniProtKB/Swiss-Prot
    Q8BND4
    Related
    ENSMUSP00000139507.2, ENSMUST00000186445.7
    Conserved Domains (2) summary
    pfam13519
    Location:4 → 103
    VWA_2; von Willebrand factor type A domain
    pfam15300
    Location:777 → 838
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  3. XM_036161919.1 → XP_036017812.1  integrator complex subunit 6-like isoform X3

    Conserved Domains (2) summary
    pfam13519
    Location:4 → 103
    VWA_2; von Willebrand factor type A domain
    pfam15300
    Location:771 → 832
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  4. XM_036161921.1 → XP_036017814.1  integrator complex subunit 6-like isoform X5

    Conserved Domains (1) summary
    pfam15300
    Location:378 → 439
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  5. XM_036161920.1 → XP_036017813.1  integrator complex subunit 6-like isoform X4

    UniProtKB/TrEMBL
    F6WNG1
    Related
    ENSMUSP00000118865.2, ENSMUST00000143142.8
    Conserved Domains (1) summary
    pfam15300
    Location:564 → 625
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

RNA

  1. XR_003953008.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BND4.1 GenPept UniProtKB/Swiss-Prot:Q8BND4

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