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Usp11 ubiquitin specific peptidase 11 [ Mus musculus (house mouse) ]

Gene ID: 236733, updated on 21-Apr-2024

Summary

Official Symbol
Usp11provided by MGI
Official Full Name
ubiquitin specific peptidase 11provided by MGI
Primary source
MGI:MGI:2384312
See related
Ensembl:ENSMUSG00000031066 AllianceGenome:MGI:2384312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4085; 6230415D12Rik
Summary
Predicted to enable thiol-dependent deubiquitinase and transcription corepressor binding activity. Predicted to be involved in protein deubiquitination. Predicted to act upstream of or within proteolysis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain; dorsal root ganglion; and spinal cord. Orthologous to human USP11 (ubiquitin specific peptidase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 22.1), whole brain E14.5 (RPKM 21.8) and 23 other tissues See more
Orthologs
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Genomic context

Location:
X A1.3; X 16.2 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20570148..20586778)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (20703909..20720539)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-like modifier activating enzyme 1 Neighboring gene STARR-positive B cell enhancer mm9_chrX:20264845-20265145 Neighboring gene cyclin dependent kinase 16 Neighboring gene predicted gene, 39499 Neighboring gene predicted gene, 39500 Neighboring gene STARR-seq mESC enhancer starr_46882 Neighboring gene predicted gene, 26065 Neighboring gene Araf proto-oncogene, serine/threonine kinase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC6649, KIAA4085

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 11
Names
deubiquitinating enzyme 11
ubiquitin thioesterase 11
ubiquitin thiolesterase 11
ubiquitin-specific-processing protease 11
NP_001345860.1
NP_663603.3
XP_030107181.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358931.1NP_001345860.1  ubiquitin carboxyl-terminal hydrolase 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL807240
    UniProtKB/TrEMBL
    Q8C0C2
    Conserved Domains (1) summary
    cl02553
    Location:1774
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  2. NM_145628.4NP_663603.3  ubiquitin carboxyl-terminal hydrolase 11 isoform 1

    See identical proteins and their annotated locations for NP_663603.3

    Status: VALIDATED

    Source sequence(s)
    AK031767, AK049053, AK169116, BY272535
    Consensus CDS
    CCDS53015.1
    UniProtKB/Swiss-Prot
    B1AXB2, Q3TLG5, Q99K46
    Related
    ENSMUSP00000033383.3, ENSMUST00000033383.3
    Conserved Domains (6) summary
    smart00695
    Location:44136
    DUSP; Domain in ubiquitin-specific proteases
    COG5560
    Location:23888
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02674
    Location:737887
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:258437
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam14533
    Location:428541
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam14836
    Location:154233
    Ubiquitin_3; Ubiquitin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    20570148..20586778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251321.1XP_030107181.1  ubiquitin carboxyl-terminal hydrolase 11 isoform X1

    UniProtKB/TrEMBL
    Q8C0C2
    Conserved Domains (1) summary
    COG5560
    Location:39654
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]