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Sytl5 synaptotagmin-like 5 [ Mus musculus (house mouse) ]

Gene ID: 236643, updated on 5-Mar-2024

Summary

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Official Symbol
Sytl5provided by MGI
Official Full Name
synaptotagmin-like 5provided by MGI
Primary source
MGI:MGI:2668451
See related
Ensembl:ENSMUSG00000054453 AllianceGenome:MGI:2668451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
slp5
Summary
Predicted to enable neurexin family protein binding activity. Acts upstream of or within exocytosis. Predicted to be located in membrane. Predicted to be active in exocytic vesicle and plasma membrane. Orthologous to human SYTL5 (synaptotagmin like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 1.4), liver E18 (RPKM 0.5) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A1.1; X 4.62 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (9613851..9871268)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (9747622..9998864)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46712 Neighboring gene H2A histone family member L1O Neighboring gene STARR-seq mESC enhancer starr_46713 Neighboring gene dynein light chain Tctex-type 3 Neighboring gene STARR-seq mESC enhancer starr_46715 Neighboring gene H2A histone family member L3 Neighboring gene H2A.P histone Neighboring gene STARR-seq mESC enhancer starr_46716 Neighboring gene predicted gene 5754 Neighboring gene STARR-seq mESC enhancer starr_46717 Neighboring gene sushi-repeat-containing protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. Kuroda TS, et al. Biochem Biophys Res Commun, 2002 May 10. PMID 12051743
  2. Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. Fukuda M. J Biol Chem, 2003 Apr 25. PMID 12590134
  3. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA. Scavuzzo MA, et al. Cell Rep, 2018 Dec 26. PMID 30590051
  4. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
  5. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables neurexin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
synaptotagmin-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290728.1 → NP_001277657.1  synaptotagmin-like protein 5 isoform 2

    See identical proteins and their annotated locations for NP_001277657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL672031, BX547929
    Consensus CDS
    CCDS72342.1
    UniProtKB/Swiss-Prot
    Q80T23
    Related
    ENSMUSP00000083339.4, ENSMUST00000086165.4
    Conserved Domains (4) summary
    cd04020
    Location:545 → 723
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:408 → 531
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  2. NM_177704.3 → NP_808372.1  synaptotagmin-like protein 5 isoform 1

    See identical proteins and their annotated locations for NP_808372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL672031, BX547929
    Consensus CDS
    CCDS40860.1
    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Related
    ENSMUSP00000064826.3, ENSMUST00000067529.9
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    9613851..9871268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318467.3 → XP_017173956.1  synaptotagmin-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  2. XM_011247463.4 → XP_011245765.1  synaptotagmin-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011245765.1

    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  3. XM_011247469.4 → XP_011245771.1  synaptotagmin-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011245771.1

    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  4. XM_036161915.1 → XP_036017808.1  synaptotagmin-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  5. XM_006527604.5 → XP_006527667.1  synaptotagmin-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006527667.1

    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  6. XM_006527608.5 → XP_006527671.1  synaptotagmin-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006527671.1

    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  7. XM_011247470.4 → XP_011245772.1  synaptotagmin-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011245772.1

    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  8. XM_036161913.1 → XP_036017806.1  synaptotagmin-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  9. XM_011247473.2 → XP_011245775.1  synaptotagmin-like protein 5 isoform X2

    See identical proteins and their annotated locations for XP_011245775.1

    UniProtKB/Swiss-Prot
    Q80T23
    Conserved Domains (4) summary
    cd04020
    Location:545 → 723
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:408 → 531
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  10. XM_011247468.2 → XP_011245770.1  synaptotagmin-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011245770.1

    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  11. XM_011247465.2 → XP_011245767.1  synaptotagmin-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011245767.1

    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  12. XM_036161914.1 → XP_036017807.1  synaptotagmin-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  13. XM_011247464.2 → XP_011245766.1  synaptotagmin-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011245766.1

    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  14. XM_011247460.3 → XP_011245762.1  synaptotagmin-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011245762.1

    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  15. XM_011247471.3 → XP_011245773.1  synaptotagmin-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011245773.1

    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  16. XM_006527607.4 → XP_006527670.1  synaptotagmin-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006527670.1

    UniProtKB/Swiss-Prot
    A2AF59, Q80T23, Q812E5
    UniProtKB/TrEMBL
    A2AF58
    Conserved Domains (4) summary
    cd04020
    Location:567 → 745
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:430 → 553
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15766
    Location:62 → 108
    FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
    cl22851
    Location:11 → 123
    PHD_SF; PHD finger superfamily

  17. XM_030251313.2 → XP_030107173.1  synaptotagmin-like protein 5 isoform X3

    Conserved Domains (2) summary
    cd04020
    Location:283 → 461
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:146 → 269
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80T23.1 GenPept UniProtKB/Swiss-Prot:Q80T23

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