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Gbp9 guanylate-binding protein 9 [ Mus musculus (house mouse) ]

Gene ID: 236573, updated on 3-Apr-2024

Summary

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Official Symbol
Gbp9provided by MGI
Official Full Name
guanylate-binding protein 9provided by MGI
Primary source
MGI:MGI:3605620
See related
Ensembl:ENSMUSG00000029298 AllianceGenome:MGI:3605620
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within adhesion of symbiont to host and defense response to other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is expressed in meninges and thymus primordium. Orthologous to human GBP6 (guanylate binding protein family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 6.1), lung adult (RPKM 5.7) and 25 other tissues See more
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Genomic context

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Location:
5 E5; 5 50.68 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105224331..105258255, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105076464..105110357, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13846 Neighboring gene Sec61 beta subunit pseudogene Neighboring gene guanylate-binding protein 8 Neighboring gene STARR-seq mESC enhancer starr_13847 Neighboring gene guanylate binding protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E1304 Neighboring gene predicted gene, 53274

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies. Kresse A, et al. BMC Genomics, 2008 Apr 10. PMID 18402675, Free PMC Article
  2. Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. Degrandi D, et al. J Immunol, 2007 Dec 1. PMID 18025219
  3. Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Simpson DS, et al. Immunity, 2022 Mar 8. PMID 35139355, Free PMC Article
  4. A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection. Kim BH, et al. Science, 2011 May 6. PMID 21551061
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • E430029F06

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adhesion of symbiont to host IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to protozoan IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in symbiont-containing vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
guanylate binding protein family, member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424671.1 → NP_001411600.1  guanylate binding protein family, member 9 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC144914
    UniProtKB/TrEMBL
    Q8BTS3

  2. NM_001424672.1 → NP_001411601.1  guanylate binding protein family, member 9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC144914

  3. NM_172777.5 → NP_766365.1  guanylate binding protein family, member 9 isoform 1

    See identical proteins and their annotated locations for NP_766365.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
    Source sequence(s)
    AC144914
    Consensus CDS
    CCDS39191.1
    UniProtKB/TrEMBL
    Q6PG83, Q8BTS3
    Related
    ENSMUSP00000031238.7, ENSMUST00000031238.13
    Conserved Domains (2) summary
    pfam02263
    Location:16 → 279
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:281 → 575
    GBP_C; Guanylate-binding protein, C-terminal domain

RNA

  1. NR_153378.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 3' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC144914

  2. NR_188839.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC144914

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    105224331..105258255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004942512.1 RNA Sequence

    Related
    ENSMUST00000196820.5

  2. XR_003955638.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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