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ARFIP2 ADP ribosylation factor interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 23647, updated on 3-Apr-2024

Summary

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Official Symbol
ARFIP2provided by HGNC
Official Full Name
ADP ribosylation factor interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:17160
See related
Ensembl:ENSG00000132254 MIM:601638; AllianceGenome:HGNC:17160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POR1
Summary
Enables several functions, including GTP-dependent protein binding activity; membrane curvature sensor activity; and phosphatidylinositol-4-phosphate binding activity. Involved in actin cytoskeleton organization. Located in cell cortex; ruffle; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 12.1), thyroid (RPKM 9.1) and 25 other tissues See more
Orthologs
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Genomic context

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See ARFIP2 in Genome Data Viewer
Location:
11p15.4
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6476519..6481331, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6534991..6539815, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6497749..6502561, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3102 Neighboring gene hemopexin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4341 Neighboring gene tripartite motif containing 3 Neighboring gene Sharpr-MPRA regulatory region 6512 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6493832-6494771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6494772-6495710 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:6502154-6503353 Neighboring gene translocase of inner mitochondrial membrane 10B Neighboring gene voltage dependent anion channel 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/NEMO and inhibiting IKKβ kinase activity. You DJ, et al. Cell Signal, 2015 Nov. PMID 26296658
  2. Arf1 and membrane curvature cooperate to recruit Arfaptin2 to liposomes. Ambroggio EE, et al. PLoS One, 2013. PMID 23638170, Free PMC Article
  3. Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase. Nakamura K, et al. J Biol Chem, 2012 Jul 20. PMID 22679020, Free PMC Article
  4. The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways. Tarricone C, et al. Nature, 2001 May 10. PMID 11346801
  5. Circular RNA circ-ARFIP2 regulates proliferation, migration and invasion in human vascular smooth muscle cells via miR-338-3p-dependent modulation of KDR. Qin K, et al. Metab Brain Dis, 2021 Aug. PMID 33837886

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deciphering the immunological and prognostic features of hepatocellular carcinoma through ADP-ribosylation-related genes analysis and identify potential therapeutic target ARFIP2.
    Title: Deciphering the immunological and prognostic features of hepatocellular carcinoma through ADP-ribosylation-related genes analysis and identify potential therapeutic target ARFIP2.
  2. Circular RNA circ-ARFIP2 regulates proliferation, migration and invasion in human vascular smooth muscle cells via miR-338-3p-dependent modulation of KDR.
    Title: Circular RNA circ-ARFIP2 regulates proliferation, migration and invasion in human vascular smooth muscle cells via miR-338-3p-dependent modulation of KDR.
  3. The data indicate that arfaptin 2 is the first molecule to regulate NF-kappaB signaling by interacting with the functional IkappaB kinase complex but not by direct inhibiting IKKbeta phosphorylation.
    Title: Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/NEMO and inhibiting IKKβ kinase activity.
  4. both Arf1 activation and high membrane curvature are required for efficient recruitment of Arfaptin2 to membranes
    Title: Arf1 and membrane curvature cooperate to recruit Arfaptin2 to liposomes.
  5. The binding of arfaptin1, but not arfaptin2, to PI(4)P is regulated by protein kinase D (PKD) mediated phosphorylation at Ser100 within the AH.
    Title: Recruitment of arfaptins to the trans-Golgi network by PI(4)P and their involvement in cargo export.
  6. The Arl1.Arfaptin-2 BAR structure suggests that one of the two Arl1 molecules competes with Rac1, which binds to the concave face of the Arfaptin-2 BAR homodimer and may hinder its membrane association.
    Title: Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase.
  7. arfaptin 2 phosphorylation at Ser260 by Akt inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment
    Title: Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment.
  8. arfaptin 2 is involved in regulating huntingtin protein aggregation
    Title: Arfaptin 2 regulates the aggregation of mutant huntingtin protein.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ18046, FLJ18697, FLJ99239

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding TAS
Traceable Author Statement
more info
 PubMed 
enables GTP-dependent protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cadherin binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables membrane curvature sensor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lamellipodium assembly TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to phagophore assembly site IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ruffle organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in small GTPase-mediated signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in ruffle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
arfaptin-2
Names
partner of RAC1 (arfaptin 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242854.3 → NP_001229783.1  arfaptin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Consensus CDS
    CCDS73250.1
    UniProtKB/TrEMBL
    A0A087X1E4, B4DUZ3
    Related
    ENSP00000484121.1, ENST00000614314.4
    Conserved Domains (1) summary
    cd07660
    Location:169 → 356
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  2. NM_001242855.3 → NP_001229784.1  arfaptin-2 isoform 3

    See identical proteins and their annotated locations for NP_001229784.1

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Consensus CDS
    CCDS55740.1
    UniProtKB/TrEMBL
    B4DXH2
    Related
    ENSP00000398375.2, ENST00000423813.6
    Conserved Domains (1) summary
    cd07660
    Location:98 → 285
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  3. NM_001242856.3 → NP_001229785.1  arfaptin-2 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001229785.1

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Consensus CDS
    CCDS55739.1
    UniProtKB/Swiss-Prot
    P53365
    Related
    ENSP00000391427.2, ENST00000445086.6
    Conserved Domains (1) summary
    cd07660
    Location:51 → 238
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  4. NM_001370406.2 → NP_001357335.1  arfaptin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC084337
    UniProtKB/TrEMBL
    B4DXH2
    Conserved Domains (1) summary
    cd07660
    Location:136 → 322
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  5. NM_001370408.2 → NP_001357337.1  arfaptin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Consensus CDS
    CCDS55740.1
    UniProtKB/TrEMBL
    B4DXH2
    Conserved Domains (1) summary
    cd07660
    Location:98 → 285
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  6. NM_001370409.2 → NP_001357338.1  arfaptin-2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC084337
    UniProtKB/TrEMBL
    B4DXH2
    Conserved Domains (1) summary
    cd07660
    Location:136 → 318
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  7. NM_001370411.2 → NP_001357340.1  arfaptin-2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC084337
    UniProtKB/TrEMBL
    B4DXH2
    Conserved Domains (1) summary
    cd07660
    Location:136 → 318
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  8. NM_001370412.2 → NP_001357341.1  arfaptin-2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC084337
    UniProtKB/TrEMBL
    B4DXH2
    Conserved Domains (1) summary
    cd07660
    Location:120 → 307
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  9. NM_001370413.2 → NP_001357342.1  arfaptin-2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC084337
    UniProtKB/TrEMBL
    B4DXH2
    Conserved Domains (1) summary
    cd07660
    Location:120 → 307
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  10. NM_001376558.2 → NP_001363487.1  arfaptin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Consensus CDS
    CCDS7765.1
    UniProtKB/Swiss-Prot
    B4DX86, B4E306, D3DQT5, P53365
    UniProtKB/TrEMBL
    B4DXH2
    Related
    ENSP00000379998.3, ENST00000396777.8
    Conserved Domains (1) summary
    cd07660
    Location:136 → 323
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  11. NM_001376559.2 → NP_001363488.1  arfaptin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC084337
    UniProtKB/TrEMBL
    B4DXH2
    Conserved Domains (1) summary
    cd07660
    Location:136 → 322
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  12. NM_001376560.2 → NP_001363489.1  arfaptin-2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC084337
    UniProtKB/TrEMBL
    B4DXH2
    Conserved Domains (1) summary
    cd07660
    Location:136 → 321
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  13. NM_001376561.2 → NP_001363490.1  arfaptin-2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC084337
    UniProtKB/TrEMBL
    B4DXH2
    Conserved Domains (1) summary
    cd07660
    Location:136 → 290
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  14. NM_001376562.2 → NP_001363491.1  arfaptin-2 isoform 12 precursor

    Status: VALIDATED

    Source sequence(s)
    AC084337
    UniProtKB/TrEMBL
    B4DXH2
    Conserved Domains (1) summary
    cd07660
    Location:108 → 295
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  15. NM_001376563.2 → NP_001363492.1  arfaptin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Consensus CDS
    CCDS55740.1
    UniProtKB/TrEMBL
    B4DXH2
    Conserved Domains (1) summary
    cd07660
    Location:98 → 285
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  16. NM_001376564.2 → NP_001363493.1  arfaptin-2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC084337
    UniProtKB/TrEMBL
    B4DXH2
    Conserved Domains (1) summary
    cd07660
    Location:98 → 284
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  17. NM_012402.5 → NP_036534.1  arfaptin-2 isoform 2

    See identical proteins and their annotated locations for NP_036534.1

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Consensus CDS
    CCDS7765.1
    UniProtKB/Swiss-Prot
    B4DX86, B4E306, D3DQT5, P53365
    UniProtKB/TrEMBL
    B4DXH2
    Related
    ENSP00000254584.2, ENST00000254584.6
    Conserved Domains (1) summary
    cd07660
    Location:136 → 323
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

RNA

  1. NR_163423.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084337
    Related
    ENST00000531037.5

  2. NR_163424.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084337

  3. NR_164825.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084337

  4. NR_164826.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084337

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    6476519..6481331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426687.1 → XP_047282643.1  arfaptin-2 isoform X1

    Conserved Domains (1) summary
    cd07660
    Location:136 → 290
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    6534991..6539815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368252.1 → XP_054224227.1  arfaptin-2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53365.1 GenPept UniProtKB/Swiss-Prot:P53365

Gene LinkOut

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